This feature article reviews the synthesis, structural comparison, and physical properties of [2Fe-2S] model compounds, which serve as vital tools for understanding the structure and function of Fe-S clusters in biological systems. We explore various synthetic methods for constructing [2Fe-2S] cores, offering insights into their biomimetic relevance. A comprehensive analysis and comparison of Mössbauer spectroscopy data between model compounds and natural protein systems are provided, highlighting the structural and electronic parallels. Additionally, we discuss the redox potentials of synthetic [2Fe-2S] compounds, their deviation from biological systems, and potential strategies to align them with natural counterparts. The review concludes with a discussion of future research directions, particularly the development of models capable of mimicking biological processes such as catalysis and electron transfer reactions. This article serves as a valuable resource for researchers in inorganic chemistry, bioinorganic chemistry, biochemistry, and related fields, offering both fundamental insights and potential applications of [2Fe-2S] clusters.

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