Alexander BM, Cloughesy TF (2017) Adult glioblastoma. J Clin Oncol 35:2402–2409. https://doi.org/10.1200/jco.2017.73.0119

Article  CAS  PubMed  Google Scholar 

Ambrogini P, Lattanzi D, Ciuffoli S, Agostini D, Bertini L, Stocchi V et al (2004) Morpho-functional characterization of neuronal cells at different stages of maturation in granule cell layer of adult rat dentate gyrus. Brain Res 1017:21–31. https://doi.org/10.1016/j.brainres.2004.05.039

Article  CAS  PubMed  Google Scholar 

Antonelli M, Poliani PL (2022) Adult type diffuse gliomas in the new 2021 WHO classification. Pathologica 114:397–409. https://doi.org/10.32074/1591-951X-823

Article  PubMed  PubMed Central  Google Scholar 

Bernal A, Arranz L (2018) Nestin-expressing progenitor cells: function, identity and therapeutic implications. Cell Mol Life Sci 75:2177–2195. https://doi.org/10.1007/s00018-018-2794-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J et al (2010) The landscape of somatic copy-number alteration across human cancers. Nature 463:899–905. https://doi.org/10.1038/nature08822

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhaduri A, Di Lullo E, Jung D, Muller S, Crouch EE, Espinosa CS et al (2020) Outer radial glia-like cancer stem cells contribute to heterogeneity of glioblastoma. Cell Stem Cell 26(48–63):e46. https://doi.org/10.1016/j.stem.2019.11.015

Article  CAS  Google Scholar 

Bragelmann J, Bohm S, Guthrie MR, Mollaoglu G, Oliver TG, Sos ML (2017) Family matters: how MYC family oncogenes impact small cell lung cancer. Cell Cycle 16:1489–1498. https://doi.org/10.1080/15384101.2017.1339849

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cahoy JD, Emery B, Kaushal A, Foo LC, Zamanian JL, Christopherson KS et al (2008) A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci 28:264–278. https://doi.org/10.1523/jneurosci.4178-07.2008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Capper D, Jones DTW, Sill M, Hovestadt V, Schrimpf D, Sturm D et al (2018) DNA methylation-based classification of central nervous system tumours. Nature 555:469–474. https://doi.org/10.1038/nature26000

Article  CAS  PubMed  PubMed Central  Google Scholar 

Capper D, Stichel D, Sahm F, Jones DTW, Schrimpf D, Sill M et al (2018) Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience. Acta Neuropathol 136:181–210. https://doi.org/10.1007/s00401-018-1879-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA et al (2012) The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2:401–404. https://doi.org/10.1158/2159-8290.CD-12-0095

Article  PubMed  Google Scholar 

Chatterjee A, Stockwell PA, Ahn A, Rodger EJ, Leichter AL, Eccles MR (2017) Genome-wide methylation sequencing of paired primary and metastatic cell lines identifies common DNA methylation changes and a role for EBF3 as a candidate epigenetic driver of melanoma metastasis. Oncotarget 8:6085–6101. https://doi.org/10.18632/oncotarget.14042

Article  PubMed  Google Scholar 

Chen J, Guanizo A, Luong Q, Jayasekara WSN, Jayasinghe D, Inampudi C et al (2022) Lineage-restricted neoplasia driven by Myc defaults to small cell lung cancer when combined with loss of p53 and Rb in the airway epithelium. Oncogene 41:138–145. https://doi.org/10.1038/s41388-021-02070-3

Article  CAS  PubMed  Google Scholar 

Chkheidze R, Raisanen J, Gagan J, Richardson TE, Pinho MC, Raj K et al (2021) Alterations in the RB pathway with inactivation of RB1 characterize glioblastomas with a primitive neuronal component. J Neuropathol Exp Neurol 80:1092–1098. https://doi.org/10.1093/jnen/nlab109

Article  CAS  PubMed  Google Scholar 

Cominelli M, Grisanti S, Mazzoleni S, Branca C, Buttolo L, Furlan D et al (2015) EGFR amplified and overexpressing glioblastomas and association with better response to adjuvant metronomic temozolomide. J Natl Cancer Inst 107(5):djv041. https://doi.org/10.1093/jnci/djv041

Article  CAS  PubMed  Google Scholar 

Conti V, Cominelli M, Pieri V, Gallotti AL, Pagano I, Zanella M et al (2021) mTORC1 promotes malignant large cell/anaplastic histology and is a targetable vulnerability in SHH-TP53 mutant medulloblastoma. JCI Insight 6(23):e153462. https://doi.org/10.1172/jci.insight.153462

Article  PubMed  PubMed Central  Google Scholar 

Corno D, Pala M, Cominelli M, Cipelletti B, Leto K, Croci L et al (2012) Gene signatures associated with mouse postnatal hindbrain neural stem cells and medulloblastoma cancer stem cells identify novel molecular mediators and predict human medulloblastoma molecular classification. Cancer Discov 2(6):554–568. https://doi.org/10.1158/2159-8290.cd-11-0199

Article  PubMed  Google Scholar 

Corti G, Bartolini A, Crisafulli G, Novara L, Rospo G, Montone M et al (2019) A genomic analysis workflow for colorectal cancer precision oncology. Clin Colorectal Cancer 18:91-101.e103. https://doi.org/10.1016/j.clcc.2019.02.008

Article  PubMed  Google Scholar 

Crisafulli G, Mussolin B, Cassingena A, Montone M, Bartolini A, Barault L et al (2019) Whole exome sequencing analysis of urine trans-renal tumour DNA in metastatic colorectal cancer patients. ESMO Open 4(6):e000572. https://doi.org/10.1136/esmoopen-2019-000572

Article  PubMed  PubMed Central  Google Scholar 

Dang CV (2012) MYC on the path to cancer. Cell 149:22–35. https://doi.org/10.1016/j.cell.2012.03.003

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Bacco F, Orzan F, Crisafulli G, Prelli M, Isella C, Casanova E et al (2023) Coexisting cancer stem cells with heterogeneous gene amplifications, transcriptional profiles, and malignancy are isolated from single glioblastomas. Cell Rep 42(8):112816. https://doi.org/10.1016/j.celrep.2023.112816

Article  CAS  PubMed  Google Scholar 

De Bacco F, Orzan F, Erriquez J, Casanova E, Barault L, Albano R et al (2021) ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma. Cell Rep 36(4):109455. https://doi.org/10.1016/j.celrep.2021.109455

Article  CAS  PubMed  Google Scholar 

Ding S, Wang X, Lv D, Tao Y, Liu S, Chen C et al (2022) EBF3 reactivation by inhibiting the EGR1/EZH2/HDAC9 complex promotes metastasis via transcriptionally enhancing vimentin in nasopharyngeal carcinoma. Cancer Lett 527:49–65. https://doi.org/10.1016/j.canlet.2021.12.010

Article  CAS  PubMed  Google Scholar 

Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S et al (2013) STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29:15–21. https://doi.org/10.1093/bioinformatics/bts635

Article  CAS  PubMed  Google Scholar 

Dubois L, Bally-Cuif L, Crozatier M, Moreau J, Paquereau L, Vincent A (1998) XCoe2, a transcription factor of the Col/Olf-1/EBF family involved in the specification of primary neurons in Xenopus. Curr Biol 8(4):199–209. https://doi.org/10.1016/s0960-9822(98)70084-3

Article  CAS  PubMed  Google Scholar 

Dulai MS, Bosanko CM, Wang AM, Horoupian DS, Boodin S, Chen PY et al (2004) Mixed cystic gliosarcoma and primitive neuroectodermal tumor: a case report. Clin Neuropathol 23:218–222 (PMID: 15581024)

CAS  PubMed  Google Scholar 

Erickson LA, Lloyd RV (2004) Practical markers used in the diagnosis of endocrine tumors. Adv Anat Pathol 11:175–189. https://doi.org/10.1097/01.pap.0000131824.77317.a7

Article  CAS  PubMed