Arnold M, Morgan E, Rumgay H, Mafra A, Singh D, Laversanne M, Vignat J, Gralow JR, Cardoso F, Siesling S, et al. Current and future burden of breast cancer: Global statistics for 2020 and 2040. Breast. 2022;66:15–23.

Article  PubMed  PubMed Central  Google Scholar 

Lazo PA. Functional implications of tetraspanin proteins in cancer biology. Cancer Sci. 2007;98(11):1666–77.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kowal J, Arras G, Colombo M, Jouve M, Morath JP, Primdal-Bengtson B, Dingli F, Loew D, Tkach M, Thery C. Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes. Proc Natl Acad Sci USA. 2016;113(8):E968–77.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013;200(4):373–83.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Colombo M, Raposo G, Thery C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 2014;30:255–89.

Article  PubMed  CAS  Google Scholar 

Dai J, Su Y, Zhong S, Cong L, Liu B, Yang J, Tao Y, He Z, Chen C, Jiang Y. Exosomes: key players in cancer and potential therapeutic strategy. Signal Transduct Target Ther. 2020;5(1):145.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Khushman M, Bhardwaj A, Patel GK, Laurini JA, Roveda K, Tan MC, Patton MC, Singh S, Taylor W, Singh AP. Exosomal markers (CD63 and CD9) expression pattern using immunohistochemistry in resected malignant and nonmalignant pancreatic specimens. Pancreas. 2017;46(6):782–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Miki Y, Yashiro M, Okuno T, Kuroda K, Togano S, Hirakawa K, Ohira M. Clinico-pathological significance of exosome marker CD63 expression on cancer cells and stromal cells in gastric cancer. PLoS One. 2018;13(9): e0202956.

Article  PubMed  PubMed Central  Google Scholar 

Lai X, Gu Q, Zhou X, Feng W, Lin X, He Y, Cao J, Liu P, Zhang H, Zheng X. Decreased expression of CD63 tetraspanin protein predicts elevated malignant potential in human esophageal cancer. Oncol Lett. 2017;13(6):4245–51.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Huang Q, Shen YJ, Hsueh CY, Zhang YF, Guo Y, Yuan XH, Hu CY, Li JY, Tao L, Gong HL, et al. Tetraspanin CD63 reduces the progression and metastasis of head and neck squamous cell carcinoma via KRT1-mediated cell cycle arrest. Heliyon. 2023;9(7): e17711.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li Y, Yu S, Li L, Chen J, Quan M, Li Q, Gao Y. KLF4-mediated upregulation of CD9 and CD81 suppresses hepatocellular carcinoma development via JNK signaling. Cell Death Dis. 2020;11(4):299.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rappa G, Green TM, Karbanova J, Corbeil D, Lorico A. Tetraspanin CD9 determines invasiveness and tumorigenicity of human breast cancer cells. Oncotarget. 2015;6(10):7970–91.

Article  PubMed  PubMed Central  Google Scholar 

Ando T, Charindra D, Shrestha M, Umehara H, Ogawa I, Miyauchi M, Takata T. Tissue inhibitor of metalloproteinase-1 promotes cell proliferation through YAP/TAZ activation in cancer. Oncogene. 2018;37(2):263–70.

Article  PubMed  CAS  Google Scholar 

Iwabuchi E, Miki Y, Xu J, Kanai A, Ishida T, Sasano H, Suzuki T. Zinc transporter ZnT5 is associated with epithelial mesenchymal transition via SMAD1 in breast cancer. Int J Exp Pathol. 2024;105(5):184–192.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wang B, Ding W, Sun K, Wang X, Xu L, Teng X. Impact of the 2018 ASCO/CAP guidelines on HER2 fluorescence in situ hybridization interpretation in invasive breast cancers with immunohistochemically equivocal results. Sci Rep. 2019;9(1):16726.

Article  PubMed  PubMed Central  Google Scholar 

Makhlouf S, Althobiti M, Toss M, Muftah AA, Mongan NP, Lee AHS, Green AR, Rakha EA. The clinical and biological significance of estrogen receptor-low positive breast cancer. Mod Pathol. 2023;36(10): 100284.

Article  PubMed  Google Scholar 

Novitskaya V, Romanska H, Dawoud M, Jones JL, Berditchevski F. Tetraspanin CD151 regulates growth of mammary epithelial cells in three-dimensional extracellular matrix: implication for mammary ductal carcinoma in situ. Cancer Res. 2010;70(11):4698–708.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sadej R, Romanska H, Kavanagh D, Baldwin G, Takahashi T, Kalia N, Berditchevski F. Tetraspanin CD151 regulates transforming growth factor beta signaling: implication in tumor metastasis. Cancer Res. 2010;70(14):6059–70.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ordas L, Costa L, Lozano A, Chevillard C, Calovoulos A, Kantar D, Fernandez L, Chauvin L, Dosset P, Doucet C, et al. Mechanical control of cell migration by the metastasis suppressor tetraspanin CD82/KAI1. Cells. 2021;10(6):1545. 

Article  PubMed  PubMed Central  CAS  Google Scholar 

Han RB, Hensley PJ, Li JM, Zhang Y, Stark TW, Heller A, Qian H, Shi JF, Liu ZY, Huang JA, et al. Integrin-associated CD151 is a suppressor of prostate cancer progression. Am J Transl Res. 2020;12(4):1428–42.

PubMed  PubMed Central  CAS  Google Scholar 

Okada H, Sanezumi M, Nakajima T, Okada S, Yasuda K, Kanzaki H. Rapid down-regulation of CD63 transcription by progesterone in human endometrial stromal cells. Mol Hum Reprod. 1999;5(6):554–8.

Article  PubMed  CAS  Google Scholar 

Harvey K, Tapon N. The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network. Nat Rev Cancer. 2007;7(3):182–91.

Article  PubMed  CAS  Google Scholar 

Yu FX, Zhao B, Guan KL. Hippo pathway in organ size control, tissue homeostasis, and cancer. Cell. 2015;163(4):811–28.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cordenonsi M, Zanconato F, Azzolin L, Forcato M, Rosato A, Frasson C, Inui M, Montagner M, Parenti AR, Poletti A, et al. The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell. 2011;147(4):759–72.

Article  PubMed  CAS  Google Scholar 

Yu SJ, Hu JY, Kuang XY, Luo JM, Hou YF, Di GH, Wu J, Shen ZZ, Song HY, Shao ZM. MicroRNA-200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer. Clin Cancer Res. 2013;19(6):1389–99.

Article  PubMed  CAS  Google Scholar 

Zhu C, Li L, Zhang Z, Bi M, Wang H, Su W, Hernandez K, Liu P, Chen J, Chen M, et al. A Non-canonical Role of YAP/TEAD is required for activation of estrogen-regulated enhancers in breast cancer. Mol Cell. 2019;75(4):791–806e798. 

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li X, Zhuo S, Zhuang T, Cho YS, Wu G, Liu Y, Mu K, Zhang K, Su P, Yang Y, et al. YAP inhibits ERalpha and ER(+) breast cancer growth by disrupting a TEAD-ERalpha signaling axis. Nat Commun. 2022;13(1):3075.

Article  PubMed  PubMed Central  CAS  Google Scholar