Bochner R, Tieder JS, Sullivan E, Hall M, Stephans A, Mittal MK, Singh N, Delaney A, Harper B, Shastri N, Hochreiter D, Neuman MI (2021) Explanatory diagnoses following hospitalization for a brief resolved unexplained event. Pediatrics 148

Duncan DR, Growdon AS, Liu E, Larson K, Gonzalez M, Norris K, Rosen RL (2019) The impact of the American academy of pediatrics brief resolved unexplained event guidelines on gastrointestinal testing and prescribing practices. J Pediatr 211(112–119):e114

Google Scholar 

Tieder JS, Bonkowsky JL, Etzel RA, Franklin WH, Gremse DA, Herman B, Katz ES, Krilov LR, Merritt JL, 2nd, Norlin C, Percelay J, Sapién RE, Shiffman RN, Smith MB (2016) Brief resolved unexplained events (formerly apparent life-threatening events) and evaluation of lower-risk infants. Pediatrics 137

Tieder JS, Sullivan E, Stephans A, Hall M, DeLaroche AM, Wilkins V, Neuman MI, Mittal MK, Kane E, Jain S, Shastri N, Katsogridakis Y, Vachani JG, Hochreiter D, Kim E, Nicholson J, Bochner R, Murphy K (2021) Risk factors and outcomes after a brief resolved unexplained event: a multicenter study. Pediatrics 148

DeLaroche AM, Haddad R, Farooqi A, Sapién RE, Tieder JS (2020) Outcome prediction of higher-risk brief resolved unexplained events. Hosp Pediatr 10:303–310

Article  PubMed  Google Scholar 

Merritt JL, 2nd, Quinonez RA, Bonkowsky JL, Franklin WH, Gremse DA, Herman BE, Jenny C, Katz ES, Krilov LR, Norlin C, Sapién RE, Tieder JS (2019) A framework for evaluation of the higher-risk infant after a brief resolved unexplained event. Pediatrics 144

Ramgopal S, Noorbakhsh KA, Callaway CW, Wilson PM, Pitetti RD (2019) Changes in the management of children with brief resolved unexplained events (BRUEs). Pediatrics 144

Ramgopal S, Colgan JY, Roland D, Pitetti RD, Katsogridakis Y (2021) Brief resolved unexplained events: a new diagnosis, with implications for evaluation and management. European journal of pediatrics

Brand DA, Mock A, Cohn E, Krilov LR (2021) Implementing the 2016 American academy of pediatrics guideline on brief resolved unexplained events: the parent’s perspective. Pediatr Emerg Care 37:e243–e248

Article  PubMed  Google Scholar 

Duncan DR, Liu E, Growdon AS, Larson K, Rosen RL (2022) A prospective study of brief resolved unexplained events: risk factors for persistent symptoms. Hosp Pediatr 12:1030–1043

Article  PubMed  PubMed Central  Google Scholar 

Khan A, Wallace SS, Sampayo EM, Falco C (2019) Caregivers’ perceptions and hospital experience after a brief resolved unexplained event: a qualitative study. Hosp Pediatr 9:508–515

Article  PubMed  Google Scholar 

Arad-Cohen N, Cohen A, Tirosh E (2000) The relationship between gastroesophageal reflux and apnea in infants. J Pediatr 137:321–326

Article  PubMed  CAS  Google Scholar 

Jilani NZ, Hussain A, Al Ansari K, Powell CVE (2019) Gastro-oesophageal reflux is not a major cause of brief resolved unexplained events in infants. Breathe (Sheff) 15:e32–e39

Article  PubMed  Google Scholar 

Mousa H, Woodley FW, Metheney M, Hayes J (2005) Testing the association between gastroesophageal reflux and apnea in infants. J Pediatr Gastroenterol Nutr 41:169–177

Article  PubMed  Google Scholar 

Omari TI (2009) Apnea-associated reduction in lower esophageal sphincter tone in premature infants. J Pediatr 154:374–378

Article  PubMed  Google Scholar 

Smits MJ, van Wijk MP, Langendam MW, Benninga MA, Tabbers MM (2014) Association between gastroesophageal reflux and pathologic apneas in infants: a systematic review. Neurogastroenterol Motil Off J Eur Gastrointest Motil Soc 26:1527–1538

Article  Google Scholar 

Duncan DR, DiFilippo C, Kane M, Lurie M, McSweeney ME, Rosen RL (2021) Overlapping symptoms of gastroesophageal reflux and aspiration highlight the limitations of validated questionnaires. J Pediatr Gastroenterol Nutr 72:372–377

Article  PubMed  PubMed Central  Google Scholar 

Fishbein M, Branham C, Fraker C, Walbert L, Cox S, Scarborough D (2013) The incidence of oropharyngeal dysphagia in infants with GERD-like symptoms. JPEN J Parenter Enteral Nutr 37:667–673

Article  PubMed  Google Scholar 

Snel A, Barnett CP, Cresp TL, Haslam RR, Davidson GP, Malbert TH, Dent J, Omari TI (2000) Behavior and gastroesophageal reflux in the premature neonate. J Pediatr Gastroenterol Nutr 30:18–21

PubMed  CAS  Google Scholar 

Duncan DR, Mitchell PD, Larson K, Rosen RL (2018) Presenting signs and symptoms do not predict aspiration risk in children. J Pediatr 201:141–146

Article  PubMed  PubMed Central  Google Scholar 

Mercado-Deane MG, Burton EM, Harlow SA, Glover AS, Deane DA, Guill MF, Hudson V (2001) Swallowing dysfunction in infants less than 1 year of age. Pediatr Radiol 31:423–428

Article  PubMed  CAS  Google Scholar 

Fishbein MH, Kronberg J, Alvarado S, Bohm D, Ideran P, Scarborough DR (2023) A multidisciplinary approach to infants with GERD-like symptoms: a new paradigm. J Pediatr Gastroenterol Nutr 77:39–46

Article  PubMed  Google Scholar 

Duncan DR, Golden C, Growdon AS, Larson K, Rosen RL (2024) Brief resolved unexplained events symptoms frequently result in inappropriate gastrointestinal diagnoses and treatment. J Pediatr 27:114128

Article  Google Scholar 

Duncan DR GC, Larson K, Growdon AS, Liu E. (2024 in press) A prospective study of diagnostic testing and charges after brief resolved unexplained event. Journal of Pediatric Gastroenterology and Nutrition

Duncan DR, Amirault J, Mitchell PD, Larson K, Rosen RL (2017) Oropharyngeal dysphagia is strongly correlated with apparent life-threatening events. J Pediatr Gastroenterol Nutr 65:168–172

Article  PubMed  PubMed Central  Google Scholar 

Duncan DR, Larson K, Davidson K, May K, Rahbar R, Rosen RL (2019) Feeding interventions are associated with improved outcomes in children with laryngeal penetration. J Pediatr Gastroenterol Nutr 68:218–224

Article  PubMed  PubMed Central  Google Scholar 

Velayutham P, Irace AL, Kawai K, Dodrill P, Perez J, Londahl M, Mundy L, Dombrowski ND, Rahbar R (2018) Silent aspiration: who is at risk? Laryngoscope 128:1952–1957

Article  PubMed  Google Scholar 

Weir KA, McMahon S, Taylor S, Chang AB (2011) Oropharyngeal aspiration and silent aspiration in children. Chest 140:589–597

Article  PubMed  Google Scholar 

Duncan DR, Mitchell PD, Larson K, McSweeney ME, Rosen RL (2018) Association of proton pump inhibitors with hospitalization risk in children with oropharyngeal dysphagia. JAMA Otolaryngol Head Neck Surg 144:1116–1124

Article  PubMed  PubMed Central  Google Scholar 

Canani RB, Cirillo P, Roggero P, Romano C, Malamisura B, Terrin G, Passariello A, Manguso F, Morelli L, Guarino A (2006) Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children. Pediatrics 117:e817-820

Article  PubMed  Google Scholar 

Lassalle M, Zureik M, Dray-Spira R (2023) Proton pump inhibitor use and risk of serious infections in young children. JAMA Pediatrics

Duncan DR GC, Growdon AS, Larson K, Rosen RL (2024 in press) Brief resolved unexplained events symptoms frequently result in inappropriate gastrointestinal diagnoses and treatment. The Journal of pediatrics

Duncan DR, Cohen A, Du M, Akkara A, Catacora A, Larson K, Williams N, Rosen RL (2023) A prospective study of parental experience with thickening feeds for children with oropharyngeal dysphagia and gastroesophageal reflux. J Pediatr 260:113510

Article  PubMed  PubMed Central  Google Scholar 

Duncan DR, Larson K, Rosen RL (2019) Clinical aspects of thickeners for pediatric gastroesophageal reflux and oropharyngeal dysphagia. Curr Gastroenterol Rep 21:30

Article  PubMed  PubMed Central  Google Scholar 

Gurberg J, Birnbaum R, Daniel SJ (2015) Laryngeal penetration on videofluoroscopic swallowing study is associated with increased pneumonia in children. Int J Pediatr Otorhinolaryngol 79:1827–1830

Article  PubMed  Google Scholar 

Krummrich P, Kline B, Krival K, Rubin M (2017) Parent perception of the impact of using thickened fluids in children with dysphagia. Pediatr Pulmonol 52:1486–1494

Article  PubMed  Google Scholar 

Patra KP, Hall M, DeLaroche AM, Tieder JS (2022) Impact of the AAP guideline on management of brief resolved unexplained events. Hospital pediatrics 12:780

Article  PubMed  Google Scholar 

Feudtner C, Feinstein JA, Zhong W, Hall M, Dai D (2014) Pediatric complex chronic conditions classification system version 2: updated for ICD-10 and complex medical technology dependence and transplantation. BMC Pediatr 14:199

Article  PubMed  PubMed Central  Google Scholar 

Feudtner C, Hays RM, Haynes G, Geyer JR, Neff JM, Koepsell TD (2001) Deaths attributed to pediatric complex chronic conditions: national trends and implications for supportive care services. Pediatrics 107:E99

Article  PubMed  CAS  Google Scholar 

DeLaroche AM, Hall M, Mittal MK, Neuman MI, Stephans A, Wilkins VL, Sullivan E, Cohen A, Kaplan RL, Shastri NL, Tieder JS (2021) Accuracy of diagnostic codes for identifying brief resolved unexplained events. Hosp Pediatr 11:726–749

Article  PubMed  Google Scholar 

Hasenstab KA, Jadcherla SR (2014) Respiratory events in infants presenting with apparent life threatening events: is there an explanation from esophageal motility? J Pediatr 165:250-255.e251

Article  PubMed  PubMed Central