Challenges of cannabidiol determination in emulsified cosmetics and application of solid-phase extraction followed by HPLC-UV-MS/MS

European Commission. CosIng - cosmetic ingredient database. Available from: https://ec.europa.eu/growth/tools-databases/cosing/ (Accessed 09/12/2024).

Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30. on cosmetic products. Off J Eur Union L. November 2009;342(59):2009.

Google Scholar 

Case C-663/18, Judgment of the Court (Fourth Chamber) of 19 November 2020, ECLI identifier: ECLI:EU:C:2020:938.

Cannabis Association Netherlands. CBD in Cosmetica. Available from: https://www.blenheim.nl/en/blog/cannabis-cbd-and-thc-and-hemp-in-the-netherlands/ (Accessed 09/12/2024).

Bonn-Miller MO, Loflin MJE, Thomas BF, Marcu JP, Hyke T, Vandrey R. Labeling accuracy of cannabidiol extracts sold online. JAMA. 2017;318(17):1708–9.

Article  PubMed  PubMed Central  Google Scholar 

Pavlovic R, Nenna G, Calvi L, Panseri S, Borgonovo G, Giupponi L, et al. Quality traits of “cannabidiol oils”: cannabinoids content, terpene fingerprint and oxidation stability of European commercially available preparations. Molecules. 2018;23(5):1230.

Article  PubMed  PubMed Central  Google Scholar 

Liebling JP, Clarkson NJ, Gibbs BW, Yates AS, O’Sullivan SE. An analysis of over-the-counter cannabidiol products in the United Kingdom. Cannabis Cannabinoid Res. 2022;7(2):207–13.

Article  PubMed  PubMed Central  Google Scholar 

Johnson E, Kilgore M, Babalonis S. Label accuracy of unregulated cannabidiol (CBD) products: measured concentration vs. label claim. J Cannabis Res. 2022;4(1):28.

Article  PubMed  PubMed Central  Google Scholar 

Johnson E, Kilgore M, Babalonis S. Cannabidiol (CBD) product contamination: quantitative analysis of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) concentrations found in commercially available CBD products. Drug Alcohol Depend. 2022;237:109522.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Desmedt B, Van Campenhout P, Deconinck E. A systematic review of analytical methodologies capable of analysing phytocannabinoids in cosmetics. Drug Test Anal. 2024;16(1195):1202.

Google Scholar 

Spindle TR, Sholler DJ, Cone EJ, Murphy TP, ElSohly M, Winecker RE, et al. Cannabinoid content and label accuracy of hemp-derived topical products available online and at national retail stores. JAMA Netw Open. 2022;5(7):e2223019.

Article  PubMed  PubMed Central  Google Scholar 

Nemeskalova A, Hajkova K, Mikulu L, Sykora D, Kuchar M. Combination of UV and MS/MS detection for the LC analysis of cannabidiol-rich products. Talanta. 2020;219:121250.

Article  CAS  PubMed  Google Scholar 

Ciolino LA, Ranieri TL, Taylor AM. Commercial cannabis consumer products. Part 2: HPLC-DAD quantitative analysis of cannabis cannabinoids. Forensic Sci Int. 2018;289:438–47.

Article  CAS  PubMed  Google Scholar 

Hsu YH, Fang MC, Huang SC, Kao YM, Tseng SH, Wang DY. Determination of cannabinoids in hemp oil based cosmetic products by LC-tandem MS. J Food Drug Anal. 2021;29(3):502–9.

Article  PubMed  PubMed Central  Google Scholar 

Filer CN. Acidic cannabinoid decarboxylation. Cannabis Cannabinoid Res. 2022;7(3):262–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schettino L, Prieto M, Benedé JL, Chisvert A, Salvador A. A rapid and sensitive method for the determination of cannabidiol in cosmetic products by liquid chromatography–tandem mass spectrometry. Cosmetics. 2021;8(2):30.

Article  CAS  Google Scholar 

Huber S, Harder M, Funck K, Erharter K, Popp M, Bonn GK, et al. Novel room temperature ionic liquid for liquid-phase microextraction of cannabidiol from natural cosmetics. Separations. 2020;7(3):45.

Article  CAS  Google Scholar 

Ocana-Rios I, Okano L, Figueroa CG, Urban J, Church JS, Devedec FL, et al. An improved method for the determination of cannabidiol in topical products using ultrasound-assisted extraction and gas chromatography-mass spectrometry. J Pharm Biomed Anal. 2022;217:114840.

Article  CAS  PubMed  Google Scholar 

Meng Q, Buchanan B, Zuccolo J, Poulin MM, Gabriele J, Baranowski DC. A reliable and validated LC-MS/MS method for the simultaneous quantification of 4 cannabinoids in 40 consumer products. PLoS One. 2018;13(5):e0196396.

Article  PubMed  PubMed Central  Google Scholar 

European Medicines Agency. Guideline on bioanalytical method validation. 2012.

Eccleston GM. Emulsions and creams. In: Aulton ME, Taylor KMG, editors. Aulton’s pharmaceutics: the design and manufacture of medicines: Elsevier; 2013. p. 469.

Semi-solid preparations for cutaneous application. Ph Eur 100 (01/2019). p. 936.

European Directorate for the Quality of Medicines and Healthcare. Internal controlled vocabularies for pharmaceutical dose forms (v.1.3.0) – 9 June 2023.

Wille SMR, Coucke W, De Baere T, Peters FT. Update of standard practices for new method validation in forensic toxicology. Curr Pharm Des. 2017;23(36):5442–54.

CAS  PubMed  Google Scholar 

European Medicines Agency. ICH guideline M10 on bioanalytical method validation and study sample analysis. 2023.

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