Front. Pharmacol.

Sec. Drug Metabolism and Transport

Volume 15 - 2024 | doi: 10.3389/fphar.2024.1494646

Provisionally accepted

The final, formatted version of the article will be published soon.

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Knowledge of drug pharmacokinetics and tissue distribution is precious for ensuring patient safety and optimizing treatments. The varied use of local anesthetics, as well as the fact that anesthetics can sometimes have low therapeutic indices and numerous adverse drug reactions, makes any novel pharmacokinetics information valuable. The present manuscript describes a pharmacokinetic study of ropivacaine carried out after plane block anesthesia on an animal model, using high sensitivity, accurate, and precise LC-MS/MS bioanalysis. Both plasmatic concentrations and tissue distribution of ropivacaine and its primary active metabolite were determined. The results showed a tissue affinity of the anesthetics, a clearance of ropivacaine mainly by hepatic metabolism, and the final, mainly renal excretion of the hydroxylated metabolite. While the results cannot simply and directly be transposed

Keywords: Ropivacaine, pharmacokinetics, LC-MS/MS, Rats, HPLC

Received: 11 Sep 2024; Accepted: 18 Dec 2024.

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