Identification and Validation of Cuproptosis-Related Signature to Predict Prognosis and Characterize Tumor Immune Infiltration in Kidney Clear Cell Carcinoma

Capitanio U, Bensalah K, Bex A, Boorjian SA, Bray F, Coleman J et al (2019) Epidemiology of renal cell carcinoma. Eur Urol 75(1):74–84

Article  PubMed  Google Scholar 

Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM (2016) The 2016 WHO classification of tumours of the urinary system and male genital organs-part A: renal, penile, and testicular tumours. Eur Urol 70(1):93–105

Article  PubMed  Google Scholar 

Jonasch E, Gao J, Rathmell WK (2014) Renal cell carcinoma Bmj 349:g4797

PubMed  Google Scholar 

Siegel RL, Miller KD, Jemal A (2017) Cancer statistics, 2017. CA Cancer J Clin 67(1):7–30

Article  PubMed  Google Scholar 

Oliveri V (2022) Selective targeting of cancer cells by copper ionophores: an overview. Front Mol Biosci 9:841814

Article  PubMed  PubMed Central  Google Scholar 

Cobine PA, Moore SA, Leary SC. Getting out what you put in: copper in mitochondria and its impacts on human disease. Biochim Biophys Acta Mol Cell Res. 2021;1868(1):118867.

Aubert L, Nandagopal N, Steinhart Z, Lavoie G, Nourreddine S, Berman J et al (2020) Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer. Nat Commun 11(1):3701

Article  PubMed  PubMed Central  Google Scholar 

Stepien M, Jenab M, Freisling H, Becker NP, Czuban M, Tjønneland A et al (2017) Pre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European prospective investigation into cancer and nutrition cohort. Carcinogenesis 38(7):699–707

Article  PubMed  Google Scholar 

Ruiz LM, Libedinsky A, Elorza AA (2021) Role of copper on mitochondrial function and metabolism. Front Mol Biosci 8:711227

Article  PubMed  PubMed Central  Google Scholar 

Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M et al (2022) Copper induces cell death by targeting lipoylated TCA cycle proteins. Science 375(6586):1254–1261

Article  PubMed  PubMed Central  Google Scholar 

Steinbrueck A, Sedgwick AC, Brewster JT 2nd, Yan KC, Shang Y, Knoll DM et al (2020) Transition metal chelators, pro-chelators, and ionophores as small molecule cancer chemotherapeutic agents. Chem Soc Rev 49(12):3726–3747

Article  PubMed  Google Scholar 

Quail DF, Joyce JA (2013) Microenvironmental regulation of tumor progression and metastasis. Nat Med 19(11):1423–1437

Article  PubMed  PubMed Central  Google Scholar 

Wang JP, Tang YY, Fan CM, Guo C, Zhou YH, Li Z et al (2018) The role of exosomal non-coding RNAs in cancer metastasis. Oncotarget 9(15):12487–12502

Article  PubMed  Google Scholar 

Li X, Wenes M, Romero P, Huang SC, Fendt SM, Ho PC (2019) Navigating metabolic pathways to enhance antitumour immunity and immunotherapy. Nat Rev Clin Oncol 16(7):425–441

Article  PubMed  Google Scholar 

Vuong L, Kotecha RR, Voss MH, Hakimi AA (2019) Tumor microenvironment dynamics in clear-cell renal cell carcinoma. Cancer Discov 9(10):1349–1357

Article  PubMed  PubMed Central  Google Scholar 

Matsushita H, Sato Y, Karasaki T, Nakagawa T, Kume H, Ogawa S et al (2016) Neoantigen load, antigen presentation machinery, and immune signatures determine prognosis in clear cell renal cell carcinoma. Cancer Immunol Res 4(5):463–471

Article  PubMed  Google Scholar 

Giraldo NA, Becht E, Vano Y, Petitprez F, Lacroix L, Validire P et al (2017) Tumor-infiltrating and peripheral blood t-cell immunophenotypes predict early relapse in localized clear cell renal cell carcinoma. Clin Cancer Res 23(15):4416–4428

Article  PubMed  Google Scholar 

Sato Y, Yoshizato T, Shiraishi Y, Maekawa S, Okuno Y, Kamura T et al (2013) Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet 45(8):860–867

Article  PubMed  Google Scholar 

Hänzelmann S, Castelo R, Guinney J (2013) GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics 14:7

Article  PubMed  PubMed Central  Google Scholar 

Chen B, Khodadoust MS, Liu CL, Newman AM, Alizadeh AA (2018) Profiling tumor infiltrating immune cells with CIBERSORT. Methods Mol Biol 1711:243–259

Article  PubMed  PubMed Central  Google Scholar 

Song Q, Shang J, Yang Z, Zhang L, Zhang C, Chen J et al (2019) Identification of an immune signature predicting prognosis risk of patients in lung adenocarcinoma. J Transl Med 17(1):70

Article  PubMed  PubMed Central  Google Scholar 

Farhood B, Najafi M, Mortezaee K (2019) CD8(+) cytotoxic T lymphocytes in cancer immunotherapy: a review. J Cell Physiol 234(6):8509–8521

Article  PubMed  Google Scholar 

Motzer RJ, Banchereau R, Hamidi H, Powles T, McDermott D, Atkins MB et al (2020) Molecular subsets in renal cancer determine outcome to checkpoint and angiogenesis blockade. Cancer Cell 38(6):803–17.e4

Article  PubMed  PubMed Central  Google Scholar 

留言 (0)

沒有登入
gif