World Health Organization. Global health estimates 2020: deaths by cause, age, sex, by country and by region, 2000–2019.

Xie L, Shang Z (2022) Burden of oral cancer in Asia from 1990 to 2019: estimates from the global burden of disease 2019 study. PLoS ONE 17(3):e0265950. https://doi.org/10.1371/journal.pone.0265950.PMID:35324990;PMCID:PMC8947401

Article  PubMed  PubMed Central  Google Scholar 

Sankaranarayanan R, Ramadas K, Thomas G, Muwonge R, Thara S, Mathew B, Rajan B (2005) Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial. Lancet 365(9475):1927–1933. https://doi.org/10.1016/S0140-6736(05)66658-5

Article  PubMed  Google Scholar 

Coelho KR (2012) Challenges of the oral cancer burden in India. J Cancer Epidemiol 2012:1–17. https://doi.org/10.1155/2012/701932

Article  Google Scholar 

Patil VM, Prabhash K, Noronha V, Joshi A, Muddu V, Dhumal S, Arya S, Juvekar S, Chaturvedi P, Chaukar D, Pai P, Kane S, Patil A, Agarwal JP, Ghosh-Lashkar S, Dcruz A (2014) Neoadjuvant chemotherapy followed by surgery in very locally advanced technically unresectable oral cavity cancers. Oral Oncol 50(10):1000–1004. https://doi.org/10.1016/j.oraloncology.2014.07.015

Article  PubMed  Google Scholar 

Katna R, Kalyani N, Singh S, Bhosale B (2020) Mumbai oncology group: head and neck. Compartmental clearance of infratemporal fossa for T4b carcinoma of buccal mucosa/alveolus: clinical outcomes. Indian J Surg Oncol 11(2):316–320. https://doi.org/10.1007/s13193-020-01057-y

Article  PubMed  PubMed Central  Google Scholar 

Madera M, Tirado Amador L, Leal AC (2021) Therapeutic options in unresectable oral squamous cell carcinoma: a systematic review. Cancer Manag Res 25(13):6705–6719. https://doi.org/10.2147/CMAR.S283204.PMID:34471384;PMCID:PMC8403568

Article  Google Scholar 

Schwartz LH, Litière S, de Vries E, Ford R, Gwyther S, Mandrekar S, Shankar L, Bogaerts J, Chen A, Dancey J, Hayes W, Hodi FS, Hoekstra OS, Huang EP, Lin N, Liu Y, Therasse P, Wolchok JD, Seymour L (2016) RECIST 1.1-update and clarification: from the RECIST committee. Eur J Cancer 62:132–137. https://doi.org/10.1016/j.ejca.2016.03.081

Article  PubMed  PubMed Central  Google Scholar 

Mahajan A, Agarwal U, Patil VM, Patil V, Vaish R, Noronha V, D’Cruz AK, Chaturvedi SSP, Laskar SG, Sable N, Janu A, Patil A, Menon M, Rane S, Mittal N, Joshi A, Menon N, Prabhash K (2022) Proposed sub-compartmentalization of high infratemporal fossa involvement in gingivobuccal cancers and its impact on clinical outcome and staging: a narrative review. Cancer Res, Stat, Treat 5(2):269–275. https://doi.org/10.4103/crst.crst_293_21

Article  Google Scholar 

Bossi P, Lo Vullo S, Guzzo M, Mariani L, Granata R, Orlandi E, Locati L, Scaramellini G, Fallai C, Licitra L (2014) Preoperative chemotherapy in advanced resectable OCSCC: long-term results of a randomized phase III trial. Ann Oncol 25(2):462–466. https://doi.org/10.1093/annonc/mdt555

Article  PubMed  Google Scholar 

Chaukar D, Prabash K, Rane P, Patil VM, Thiagarajan S, Ghosh-Laskar S, Sharma S, Pai PS, Chaturvedi P, Pantvaidya G, Deshmukh A, Nair D, Nair S, Vaish R, Noronha V, Patil A, Arya S, D’Cruz A (2022) Prospective phase II open-label randomized controlled trial to compare mandibular preservation in upfront surgery with neoadjuvant chemotherapy followed by surgery in operable oral cavity cancer. J Clin Oncol 40(3):272–281. https://doi.org/10.1200/JCO.21.00179

Article  PubMed  Google Scholar 

Hitt R, López-Pousa A, Martínez-Trufero J, Escrig V, Carles J, Rizo A, Isla D, Vega ME, Martí JL, Lobo F, Pastor P, Valentí V, Belón J, Sánchez MA, Chaib C, Pallarés C, Antón A, Cervantes A, Paz-Ares L, Cortés-Funes H (2005) Phase III study comparing cisplatin plus fluorouracil to paclitaxel, cisplatin, and fluorouracil induction chemotherapy followed by chemoradiotherapy in locally advanced head and neck cancer. J Clin Oncol 23(34):8636–8645. https://doi.org/10.1200/JCO.2004.00.1990

Article  PubMed  Google Scholar 

Haddad R, O’Neill A, Rabinowits G, Tishler R, Khuri F, Adkins D, Clark J, Sarlis N, Lorch J, Beitler JJ, Limaye S, Riley S, Posner M (2013) Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial. Lancet Oncol 14(3):257–264. https://doi.org/10.1016/S1470-2045(13)70011-1

Article  PubMed  Google Scholar 

Cohen EE, Karrison TG, Kocherginsky M, Mueller J, Egan R, Huang CH, Brockstein BE, Agulnik MB, Mittal BB, Yunus F, Samant S, Raez LE, Mehra R, Kumar P, Ondrey F, Marchand P, Braegas B, Seiwert TY, Villaflor VM, Haraf DJ, Vokes EE (2014) Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. J Clin Oncol 32(25):2735–2743. https://doi.org/10.1200/JCO.2013.54.6309

Article  PubMed  PubMed Central  Google Scholar 

Blanchard P, Baujat B, Holostenco V, Bourredjem A, Baey C, Bourhis J, Pignon JP (2011) MACH-CH Collaborative group. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): a comprehensive analysis by tumour site. Radiother Oncol 100(1):33–40. https://doi.org/10.1016/j.radonc.2011.05.036

Article  PubMed  Google Scholar 

Noronha V, Dhanawat A, Patil VM, Menon N, Singh AK, Chaturvedi P, Pai P, Chaukar D, Laskar SG, Prabhash K (2024) Long-term outcomes of neo-adjuvant chemotherapy on borderline resectable oral cavity cancers: real-world data of 3266 patients and implications for clinical practice. Oral Oncol 148:106633. https://doi.org/10.1016/j.oraloncology.2023.106633

Article  PubMed  Google Scholar 

Foster CC, Melotek JM, Brisson RJ, Seiwert TY, Cohen EEW, Stenson KM, Blair EA, Portugal L, Gooi Z, Agrawal N, Vokes EE, Haraf DJ (2018) Definitive chemoradiation for locally-advanced oral cavity cancer: a 20-year experience. Oral Oncol 80:16–22. https://doi.org/10.1016/j.oraloncology.2018.03.008

Article  PubMed  Google Scholar 

Alzahrani R, Obaid A, Al-Hakami H, Alshehri A, Al-Assaf H, Adas R, Alduhaibi E, Alsafadi N, Alghamdi S, Alghamdi M (2020) Locally advanced oral cavity cancers: what is the optimal care? Cancer Control 27(1):1073274820920727. https://doi.org/10.1177/1073274820920727

Article  PubMed  PubMed Central  Google Scholar 

Ghi MG, Paccagnella A, Ferrari D, Foa P, Alterio D, Codecà C, Nolè F, Verri E, Orecchia R, Morelli F, Parisi S, Mastromauro C, Mione CA, Rossetto C, Polsinelli M, Koussis H, Loreggian L, Bonetti A, Campostrini F, Azzarello G, D’Ambrosio C, Bertoni F, Casanova C, Emiliani E, Guaraldi M, Bunkheila F, Bidoli P, Niespolo RM, Gava A, Massa E, Frattegiani A, Valduga F, Pieri G, Cipani T, Da Corte D, Chiappa F, Rulli E, GSTTC (Gruppo di Studio Tumori della Testa e del Collo) Italian Study Group (2017) Induction TPF followed by concomitant treatment versus concomitant treatment alone in locally advanced head and neck cancer. A phase II-III trial. Ann Oncol 28(9):2206–2212. https://doi.org/10.1093/annonc/mdx299

Article  PubMed  Google Scholar 

Patil VM, Noronha V, Joshi A, Kumar A, Dsouza H, Bhattacharjee A, Mahajan A, Sabale N, Ghosh-Laskar S, Prabhash K (2020) Chemoradiation in unresectable oral cavity cancer: a myth or reality! South Asian J Cancer 09(04):195–198. https://doi.org/10.1055/s-0041-1728225

Article  Google Scholar 

Chang PM, Lu HJ, Wang LW, Tai SK, Chen MH, Chu PY, Yang MH (2017) Effectiveness of incorporating cetuximab into docetaxel/cisplatin/fluorouracil induction chemotherapy and chemoradiotherapy for inoperable squamous cell carcinoma of the oral cavity: a phase II study. Head Neck 39(7):1333–1342. https://doi.org/10.1002/hed.24766

Article  PubMed  Google Scholar 

Meng J, Gu QP, Meng QF, Zhang J, Li ZP, Si YM, Guo W, Zhuang QW (2014) Efficacy of nimotuzumab combined with docetaxel-cisplatin-fluorouracil regimen in treatment of advanced oral carcinoma. Cell Biochem Biophys 68(1):181–184. https://doi.org/10.1007/s12013-013-9686-5

Article  PubMed  Google Scholar 

Yen CJ, Tsou HH, Hsieh CY, Chu CY, Chiu CF, Chen CC, Tsao CJ, Tsai KY, Tsai ST, Chang JY, Chang KY (2019) Sequential therapy of neoadjuvant biochemotherapy with cetuximab, paclitaxel, and cisplatin followed by cetuximab-based concurrent bioradiotherapy in high-risk locally advanced oral squamous cell carcinoma: final analysis of a phase 2 clinical trial. Head Neck 41(6):1703–1712. https://doi.org/10.1002/hed.25640

Article  PubMed  Google Scholar 

Jacinto AA, Batalha Filho ES, Viana LS, De Marchi P, Capuzzo RC, Gama RR, Boldrini Junior D, Santos CR, Pinto GDJ, Dias JM, Canton HP, Carvalho R, Radicchi LA, Bentzen S, Zubizarreta E, Carvalho AL (2018) Feasibility of concomitant cisplatin with hypofractionated radiotherapy for locally advanced head and neck squamous cell carcinoma. BMC Cancer 18(1):1026. https://doi.org/10.1186/s12885-018-4893-5.PMID:30352576;PMCID:PMC6199702

Article  PubMed  PubMed Central  Google Scholar