Meng, F.-C., Wu, Z.-F., Yin, Z.-Q., Lin, L.-G., Wang, R., & Zhang, Q.-W. (2018). Coptidis rhizoma and its main bioactive components: recent advances in chemical investigation, quality evaluation and pharmacological activity. Chinese Medicine, 13, 1–18.

Article  CAS  Google Scholar 

Wang, J., Wang, L., Lou, G.-H., Zeng, H.-R., Hu, J., Huang, Q.-W., Peng, W., & Yang, X.-B. (2019). Coptidis rhizoma: A comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology. Pharmaceutical biology, 57, 193–225.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Song, D., Hao, J., & Fan, D. (2020). Biological properties and clinical applications of berberine. Frontiers in Medicine, 14, 564–582.

Article  Google Scholar 

Xiong, R. G., Huang, S. Y., Wu, S. X., Zhou, D. D., Yang, Z. J., Saimaiti, A., Zhao, C. N., Shang, A., Zhang, Y. J., Gan, R. Y., & Li, H. B. (2022). Anticancer effects and mechanisms of berberine from medicinal herbs: an update review. Molecules, 27, 4523.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rauf, A., Abu-Izneid, T., Khalil, A. A., Imran, M., Shah, Z. A., Emran, T. B., Mitra, S., Khan, Z., Alhumaydhi, F. A., Aljohani, A. S. M., Khan, I., Rahman, M. M., Jeandet, P., & Gondal, T. A. (2021). Berberine as a potential anticancer agent: a comprehensive review. Molecules, 26, 368.

Article  Google Scholar 

Shakeri, F., Kiani, S., Rahimi, G., & Boskabady, M. H. (2024). Anti-inflammatory, antioxidant, and immunomodulatory effects of Berberis vulgaris and its constituent berberine, experimental and clinical, a review. Phytotherapy Research, 38, 1882–1902.

Article  PubMed  CAS  Google Scholar 

Purwaningsih, I., Maksum, I. P., Sumiarsa, D., & Sriwidodo, S. (2023). A review of fibraurea tinctoria and its component, berberine, as an antidiabetic and antioxidant. Molecules, 28, 1294.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mohammadinejad, R., Ahmadi, Z., Tavakol, S., & Ashrafizadeh, M. (2019). Berberine as a potential autophagy modulator. Journal of Celluar Physiology, 234, 14914–14926.

Article  CAS  Google Scholar 

Wang, S., Xu, Z., Cai, B., & Chen, Q. (2021). Berberine as a potential multi-target agent for metabolic diseases: a review of investigations for berberine. Endocrine, Metabolic & Immune Disorders-Drug Targets, 21, 971–979.

CAS  Google Scholar 

Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., Wang, Z., Si, S., Pan, H., Wang, S., Wu, J., Wang, Y., Li, Z., Liu, J., & Jiang, J. D. (2004). Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nature Medicine, 10, 1344–1351.

Article  PubMed  CAS  Google Scholar 

Zhao, M. M., Lu, J., Li, S., Wang, H., Cao, X., Li, Q., Shi, T. T., Matsunaga, K., Chen, C., Huang, H., Izumi, T., & Yang, J. K. (2021). Berberine is an insulin secretagogue targeting the KCNH6 potassium channel. Nature Communications, 12, 5616.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Inbaraj, J. J., Kukielczak, B. M., Bilski, P., Sandvik, S. L., & Chignell, C. F. (2001). Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 1. Berberine. Chemical Research in Toxicology, 14, 1529–1534.

Article  PubMed  CAS  Google Scholar 

Inbaraj, J. J., Kukielczak, B. M., Bilski, P., He, Y. Y., Sik, R. H., & Chignell, C. F. (2006). Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.). 2. Palmatine, hydrastine, canadine, and hydrastinine. Chemical Research in Toxicology, 19, 739–744.

Article  PubMed  CAS  Google Scholar 

Chignell, C. F., Sik, R. H., Watson, M. A., & Wielgus, A. R. (2007). Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 3: effect on human lens and retinal pigment epithelial cells. Photochemistry and Photobiology, 83, 938–943.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hirakawa, K., Kawanishi, S., & Hirano, T. (2005). The mechanism of guanine specific photooxidation in the presence of berberine and palmatine: activation of photosensitized singlet oxygen generation through DNA-binding interaction. Chemical Research in Toxicology, 18, 1545–1552.

Article  PubMed  CAS  Google Scholar 

Chahine, J., Saffon, N., Cantuel, M., & Fery-Forgues, S. (2011). Spontaneous formation of fluorescent nanofibers and reticulated solid from berberine palmitate: a new example of aggregation-induced emission enhancement in organic ion pairs. Langmuir, 27, 2844–2853.

Article  PubMed  CAS  Google Scholar 

Hirakawa, K., & Hirano, T. (2008). The microenvironment of DNA switches the activity of singlet oxygen generation photosensitized by berberine and palmatine. Photochemistry and Photobiology, 84, 202–208.

Article  PubMed  CAS  Google Scholar 

Hirakawa, K., Hirano, T., Nishimura, Y., Arai, T., & Nosaka, Y. (2012). Dynamics of singlet oxygen generation by DNA-binding photosensitizers. The Journal of Physical Chemistry B, 116, 3037–3044.

Article  PubMed  CAS  Google Scholar 

Chakraborty, G., Pillai, V. S., & Chittela, R. K. (2021). Complexation-induced tuning of optical properties of a medically important alkaloid, berberine in the presence of charged cyclodextrin. Journal of Photochemistry and Photobiology A: Chemistry, 419, 113454.

Article  CAS  Google Scholar 

Skopalová, J., Vacek, J., Papoušková, B., Jirovský, D., Maier, V., & Ranc, V. (2012). Electrochemical oxidation of berberine and mass spectrometric identification of its oxidation products. Bioelectrochemistry, 87, 15–20.

Article  PubMed  Google Scholar 

Lee, M. M. S., Zheng, L., Yu, B., Xu, W., Kwok, R. T. K., Lam, J. W. Y., Xu, F., Wang, D., & Tang, B. Z. (2019). A highly efficient and AIE-active theranostic agent from natural herbs. Materials Chemistry Frontiers, 3, 1454.

Article  CAS  Google Scholar 

Tang, X., Zhang, J., Liu, L., Yang, D., Wang, H., & He, F. (2017). Synthesis of 13-substituted derivatives of berberine: aggregation-induced emission enhancement and pH sensitive property. Journal of Photochemistry and Photobiology A: Chemistry, 337, 71–81.

Article  CAS  Google Scholar 

Xie, Y.-Y., Zhang, Y.-W., Liu, X.-Z., Ma, X.-F., Qin, X.-T., Jia, S.-R., & Zhong, C. (2021). Aggregation-induced emission-active amino acid/berberine hydrogels with enhanced photodynamic antibacterial and anti-biofilm activity. Chemical Engineering Journal, 413, 127542.

Article  CAS  Google Scholar 

Eguchi, M., Takagi, S., Tachibana, H., & Inoue, H. (2004). The ‘size matching rule’ in di-, tri-, and tetra-cationic charged porphyrin/synthetic clay complexes: effect of the inter-charge distance and the number of charged sites. Journal of Physics and Chemistry of Solids, 65, 403–407.

Article  CAS  Google Scholar 

Mori, H., Yamashina, M., Shimada, T., Ishida, T., Hirakawa, K., & Takagi, S. (2025). Enhancement of fluorescence and singlet oxygen production of berberine on clay nanosheets by surface-fixation induced emission (S-FIE). Journal of Photochemistry and Photobiology A, 459, 116039.

Article  CAS  Google Scholar 

Ni, J. S., & Lu, G. H. (2023). Natural protoberberine alkaloid-montmorillonite nanocomposite powders with AIE features for visualizing high-resolution latent fingerprints. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 300, 122908.

Article  PubMed  CAS  Google Scholar 

Wan, J., Ferreira, A., Xia, W., Chow, C. H., Takechi, K., Kamat, P. V., Jones, G., & Vullev, V. I. (2008). Solvent dependence of the charge-transfer properties of a quaterthiophene–anthraquinone dyad. Journal of Photochemistry and Photobiology A, 197, 364–374.

Article  CAS  Google Scholar 

Hirakawa, K., & Segawa, H. (2010). Effects of hydrogen bonding interaction and solvent polarity on the competition between excitation energy and photo-induced electron transfer processes in hydroxy(1-pyrenebutoxy)phosphorus(V)porphyrin. Journal of Photochemistry and Photobiology A, 213, 73–79.

Article  CAS  Google Scholar 

Nakano, S., Miyoshi, D., & Sugimoto, N. (2014). Effects of molecular crowding on the structures, interactions, and functions of nucleic acids. Chemical Reviews, 114, 2733–2758.

Article  PubMed  CAS  Google Scholar 

Wang, X.-B., Yang, J., & Wang, L.-S. (2008). Observation of entropic effect on conformation changes of complex systems under well-controlled temperature conditions. The Journal of Physical Chemistry A, 112, 172–175.

Article  PubMed  CAS  Google Scholar 

Tsukamoto, T., Shimada, T., & Takagi, S. (2013). Unique photochemical properties of p-substituted cationic triphenylbenzene derivatives on a clay layer surface. The Journal of Physical Chemistry C, 117, 2774–2779.

Article  CAS