Arosio B, Geraci A, Ferri E, Mari D, Cesari M (2022) Biological frailty index in centenarians. Aging Clin Exp Res 34(3):687–690. https://doi.org/10.1007/s40520-021-01993-x

Article  PubMed  Google Scholar 

Storci G, De Carolis S, Papi A et al (2019) Genomic stability, anti-inflammatory phenotype, and up-regulation of the RNAseH2 in cells from centenarians. Cell Death Differ 26(9):1845–1858. https://doi.org/10.1038/s41418-018-0255-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liberale L, Badimon L, Montecucco F, Lüscher TF, Libby P, Camici GG (2022) Inflammation, aging, and cardiovascular disease: JACC review topic of the week. J Am Coll Cardiol 79(8):837–847. https://doi.org/10.1016/j.jacc.2021.12.017

Article  CAS  PubMed  PubMed Central  Google Scholar 

Franceschi C, Campisi J (2014) Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci 69(Suppl 1):S4–S9. https://doi.org/10.1093/gerona/glu057

Article  PubMed  Google Scholar 

Tracey KJ (2002) The inflammatory reflex. Nature 420(6917):853–859. https://doi.org/10.1038/nature01321

Article  CAS  PubMed  Google Scholar 

Bellocchi C, Carandina A, Montinaro B et al (2022) The interplay between autonomic nervous system and inflammation across systemic autoimmune diseases. Int J Mol Sci 23(5):2449. https://doi.org/10.3390/ijms23052449

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bellocchi C, Carandina A, Della Torre A et al (2023) Transcutaneous auricular branch vagal nerve stimulation as a non-invasive add-on therapeutic approach for pain in systemic sclerosis. RMD Open 9(3):e003265. https://doi.org/10.1136/rmdopen-2023-003265

Article  PubMed  PubMed Central  Google Scholar 

Sajadieh A, Nielsen OW, Rasmussen V, Hein HO, Abedini S, Hansen JF (2004) Increased heart rate and reduced heart-rate variability are associated with subclinical inflammation in middle-aged and elderly subjects with no apparent heart disease. Eur Heart J 25(5):363–370. https://doi.org/10.1016/j.ehj.2003.12.003

Article  PubMed  Google Scholar 

Piccirillo G, Bucca C, Bauco C et al (1998) Power spectral analysis of heart rate in subjects over a hundred years old. Int J Cardiol 63(1):53–61. https://doi.org/10.1016/s0167-5273(97)00282-9

Article  CAS  PubMed  Google Scholar 

Hernández-Vicente A, Hernando D, Santos-Lozano A et al (2020) Heart rate variability and exceptional longevity. Front Physiol 11(566399):2020. https://doi.org/10.3389/fphys.2020.566399

Article  Google Scholar 

Singh JP, Larson MG, O’Donnell CJ, Tsuji H, Evans JC, Levy D (1999) Heritability of heart rate variability: the Framingham Heart Study. Circulation 99(17):2251–2254. https://doi.org/10.1161/01.cir.99.17.2251

Article  CAS  PubMed  Google Scholar 

Azzolino D, Coelho-Junior HJ, Proietti M, Manzini VM, Cesari M (2023) Fatigue in older persons: the role of nutrition. Proc Nutr Soc 82(1):39–46. https://doi.org/10.1017/S0029665122002683

Article  CAS  PubMed  Google Scholar 

Azzolino D, Rodrigues GD, Manzini VM, Proietti M, Arosio B, Montano N, Cesari M (2024) Clinical research on extreme longevity: the FACET experience. Ageing Res Rev 93:102170. https://doi.org/10.1016/j.arr.2023.102170

Article  PubMed  Google Scholar 

Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K (2008) A standard procedure for creating a frailty index. BMC Geriatr 30(8):24. https://doi.org/10.1186/1471-2318-8-24

Article  Google Scholar 

Rodrigues GD, Tobaldini E, Bellocchi C et al (2019) Cardiac autonomic modulation at rest and during orthostatic stress among different systemic sclerosis subsets. Eur J Intern Med 66:75–80. https://doi.org/10.1016/j.ejim.2019.06.003

Article  PubMed  Google Scholar 

Reginato E, Azzolina D, Folino F, Valentini R, Bendinelli C, Gafare CE, Cainelli E, Vedovelli L, Iliceto S, Gregori D, Lorenzoni G (2020) Dietary and lifestyle patterns are associated with heart rate variability. J Clin Med 9(4):1121. https://doi.org/10.3390/jcm9041121

Article  PubMed  PubMed Central  Google Scholar 

El-Malahi O, Mohajeri D, Mincu R, Bäuerle A, Rothenaicher K, Knuschke R, Rammos C, Rassaf T, Lortz J (2024) Beneficial impacts of physical activity on heart rate variability: a systematic review and meta-analysis. PLoS ONE 19(4):e0299793

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carandina A, Fanti G, Carminati A, Baroni M, Salafia G, Arosio B, Macchi C, Ruscica M, Vicenzi M, Carugo S, Borghi F, Spinazzè A, Cavallo DM, Tobaldini E, Montano N, Bonzini M (2024) Indoor air pollution impacts cardiovascular autonomic control during sleep and the inflammatory profile. Environ Res 260:119783. https://doi.org/10.1016/j.envres.2024.119783. (Epub 2024 Aug 12. PMID: 39142457)

Article  CAS  PubMed  Google Scholar 

Paolisso G, Manzella D, Barbieri M, Rizzo MR, Gambardella A, Varricchio M (1999) Baseline heart rate variability in healthy centenarians: differences compared with aged subjects (>75 years old). Clin Sci (Lond) 97(5):579–584

Article  CAS  PubMed  Google Scholar 

Franceschi C, Olivieri F, Marchegiani F et al (2005) Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech Ageing Dev 126(2):351–361. https://doi.org/10.1016/j.mad.2004.08.028

Article  CAS  PubMed  Google Scholar 

Carandina A, Rodrigues GD, Di Francesco P et al (2021) Effects of transcutaneous auricular vagus nerve stimulation on cardiovascular autonomic control in health and disease. Auton Neurosci 236:102893. https://doi.org/10.1016/j.autneu.2021.102893

Article  CAS  PubMed  Google Scholar