KM has no conflicts of interest. LB declares honoraria from Otsuka, Pfizer, GSK, Astra Zeneca and Abbvie; unrestricted educational grants from Pfizer and Otsuka. AFC declares that he has received grant support from the Scleroderma Society of Ontario; that he has received consulting fees from Actelion, Amgen, Astra Zeneca, Mallinckrodt Pharmaceuticals, Pfizer, and Vifor.