Effects of vaginal estrogen on serum estradiol during aromatase inhibitor therapy in breast cancer patients with vulvovaginal atrophy: a prospective trial

Burstein HJ, Lacchetti C, Anderson H, Buchholz TA, Davidson NE, Gelmon KA, Giordano SH, Hudis CA, Solky AJ, Stearns V et al (2019) Adjuvant endocrine therapy for women with hormone receptor-positive breast cancer: ASCO clinical practice guideline focused update. J Clin Oncol 37(5):423–438. https://doi.org/10.1200/JCO.18.01160

Article  CAS  PubMed  Google Scholar 

Bekes I, Huober J (2023) Extended adjuvant endocrine therapy in early breast cancer patients—review and perspectives. Cancers 15(16):4190. https://doi.org/10.3390/cancers15164190

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ganz PA, Rowland JH, Desmond K, Meyerowitz BE, Wyatt GE (1998) Life after breast cancer: understanding women’s health-related quality of life and sexual functioning. J Clin Oncol 16(2):501–514. https://doi.org/10.1200/jco.1998.16.2.501

Article  CAS  PubMed  Google Scholar 

Cella D, Fallowfield LJ (2008) Recognition and management of treatment-related side effects for breast cancer patients receiving adjuvant endocrine therapy. Breast Cancer Res Treat 107(2):167–180. https://doi.org/10.1007/s10549-007-9548-1

Article  CAS  PubMed  Google Scholar 

Chirgwin JH, Giobbie-Hurder A, Coates AS, Price KN, Ejlertsen B, Debled M, Gelber RD, Goldhirsch A, Smith I, Rabaglio M et al (2016) treatment adherence and its impact on disease-free survival in the breast international group 1–98 trial of tamoxifen and letrozole, alone and in sequence. J Clin Oncol 34(21):2452–2459. https://doi.org/10.1200/jco.2015.63.8619

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pearson T (2011) Atrophic Vaginitis. J Nurse Practitioners 7(6):502–512. https://doi.org/10.1016/j.nurpra.2010.08.016

Article  Google Scholar 

Trinkaus M, Chin S, Wolfman W, Simmons C, Clemons M (2008) Should urogenital atrophy in breast cancer survivors be treated with topical estrogens? Oncologist 13(3):222–231. https://doi.org/10.1634/theoncologist.2007-0234

Article  PubMed  Google Scholar 

Santen RJ, Pinkerton JV, Conaway M, Ropka M, Wisniewski L, Demers L, Klein KO (2002) Treatment of urogenital atrophy with low-dose estradiol: preliminary results. Menopause 9(3):179–187. https://doi.org/10.1097/00042192-200205000-00006

Article  PubMed  Google Scholar 

Biglia N, Peano E, Sgandurra P, Moggio G, Panuccio E, Migliardi M, Ravarino N, Ponzone R, Sismondi P (2010) Low-dose vaginal estrogens or vaginal moisturizer in breast cancer survivors with urogenital atrophy: a preliminary study. Gynecol Endocrinol 26(6):404–412. https://doi.org/10.3109/09513591003632258

Article  CAS  PubMed  Google Scholar 

Bachmann G, Lobo RA, Gut R, Nachtigall L, Notelovitz M (2008) Efficacy of low-dose estradiol vaginal tablets in the treatment of atrophic vaginitis: a randomized controlled trial. Obstet Gynecol 111(1):67–76. https://doi.org/10.1097/01.AOG.0000296714.12226.0f

Article  CAS  PubMed  Google Scholar 

Notelovitz M, Funk S, Nanavati N, Mazzeo M (2002) Estradiol absorption from vaginal tablets in postmenopausal women. Obstet Gynecol 99(4):556–562. https://doi.org/10.1016/s0029-7844(01)01385-0

Article  CAS  PubMed  Google Scholar 

Agrawal P, Singh SM, Able C, Dumas K, Kohn J, Kohn TP, Clifton M (2023) Safety of vaginal estrogen therapy for genitourinary syndrome of menopause in women with a history of breast cancer. Obstet Gynecol 142(3):660–668. https://doi.org/10.1097/aog.0000000000005294

Article  PubMed  Google Scholar 

Cold S, Cold F, Jensen M-B, Cronin-Fenton D, Christiansen P, Ejlertsen B (2022) Systemic or vaginal hormone therapy after early breast cancer: a danish observational cohort study. JNCI: J Natl Cancer Inst 114(10):1347–1354. https://doi.org/10.1093/jnci/djac112

Article  CAS  PubMed  PubMed Central  Google Scholar 

Le Ray I, Dell’Aniello S, Bonnetain F, Azoulay L, Suissa S (2012) Local estrogen therapy and risk of breast cancer recurrence among hormone-treated patients: a nested case-control study. Breast Cancer Res Treat 135(2):603–609. https://doi.org/10.1007/s10549-012-2198-y

Article  CAS  PubMed  Google Scholar 

McVicker L, Labeit AM, Coupland CAC, Hicks B, Hughes C, McMenamin Ú, McIntosh SA, Murchie P, Cardwell CR (2024) Vaginal estrogen therapy use and survival in females with breast cancer. JAMA Oncol 10(1):103–108. https://doi.org/10.1001/jamaoncol.2023.4508

Article  PubMed  Google Scholar 

Kendall A, Dowsett M, Folkerd E, Smith I (2006) Caution: Vaginal estradiol appears to be contraindicated in postmenopausal women on adjuvant aromatase inhibitors. Ann Oncol 17(4):584–587. https://doi.org/10.1093/annonc/mdj127

Article  CAS  PubMed  Google Scholar 

Sulaica E, Han T, Wang W, Bhat R, Trivedi MV, Niravath P (2016) Vaginal estrogen products in hormone receptor-positive breast cancer patients on aromatase inhibitor therapy. Breast Cancer Res Treat 157(2):203–210. https://doi.org/10.1007/s10549-016-3827-7

Article  CAS  PubMed  Google Scholar 

Wills S, Ravipati A, Venuturumilli P, Kresge C, Folkerd E, Dowsett M, Hayes DF, Decker DA (2012) Effects of vaginal estrogens on serum estradiol levels in postmenopausal breast cancer survivors and women at risk of breast cancer taking an aromatase inhibitor or a selective estrogen receptor modulator. J Oncol Pract 8(3):144–148. https://doi.org/10.1200/jop.2011.000352

Article  PubMed  PubMed Central  Google Scholar 

Pearson A, Chen J, Dhillon HM, Kiely BE (2024) Measuring serum oestrogen levels in breast cancer survivors using vaginal oestrogens: a systematic review. Breast Cancer Res Treat 206(2):215–226. https://doi.org/10.1007/s10549-024-07364-0

Article  PubMed  PubMed Central  Google Scholar 

Savolainen-Peltonen H, Hautamäki H, Tuomikoski P, Ylikorkala O, Mikkola TS (2014) Health-related quality of life in women with or without hot flashes: a randomized placebo-controlled trial with hormone therapy. Menopause 21(7):732–739. https://doi.org/10.1097/gme.0000000000000120

Article  PubMed  Google Scholar 

Faltinová M, Vehmanen L, Lyytinen H, Haanpää M, Hämäläinen E, Tiitinen A, Blomqvist C, Mattson J (2021) Monitoring serum estradiol levels in breast cancer patients during extended adjuvant letrozole treatment after five years of tamoxifen: a prospective trial. Breast Cancer Res Treat 187(3):769–775. https://doi.org/10.1007/s10549-021-06168-w

Article  CAS  PubMed  Google Scholar 

Faltinová M, Vehmanen L, Lyytinen H, Haanpää M, Hämäläinen E, Tiitinen A, Blomqvist C, Mattson J (2023) Effects of letrozole on serum estradiol and estrone in postmenopausal breast cancer patients and tolerability of treatment: a prospective trial using a highly sensitive LC-MS/MS (liquid chromatography-tandem mass spectrometry) method for estrogen measurement. Breast Cancer Res Treat 201(3):425–435. https://doi.org/10.1007/s10549-023-07054-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smith IE, Dowsett M (2003) Aromatase inhibitors in breast cancer. N Engl J Med 348(24):2431–2442. https://doi.org/10.1200/jco.2005.05.369424

Article  CAS  PubMed  Google Scholar 

Santen RJ, Mirkin S, Bernick B, Constantine GD (2020) Systemic estradiol levels with low-dose vaginal estrogens. Menopause 27(3):361–370. https://doi.org/10.1097/gme.0000000000001463

Article  PubMed  Google Scholar 

Hetemäki N, Robciuc A, Vihma V, Haanpää M, Hämäläinen E, Tikkanen MJ, Mikkola TS, Savolainen-Peltonen H (2024) Adipose tissue sex steroids in postmenopausal women with and without menopausal hormone therapy. J Clin Endocrinol Metab. https://doi.org/10.1210/clinem/dgae458

Article  PubMed  Google Scholar 

Hetemäki N, Savolainen-Peltonen H, Tikkanen MJ, Wang F, Paatela H, Hämäläinen E, Turpeinen U, Haanpää M, Vihma V, Mikkola TS (2017) Estrogen metabolism in abdominal subcutaneous and visceral adipose tissue in postmenopausal women. J Clin Endocrinol Metab 102(12):4588–4595. https://doi.org/10.1210/clinem/dgae45810.1210/jc.2017-01474

Article  PubMed  Google Scholar 

Folkerd EJ, Lønning PE, Dowsett M (2014) Interpreting plasma estrogen levels in breast cancer: caution needed. J Clin Oncol 32(14):1396–1400. https://doi.org/10.1200/jco.2013.53.9411

Article  PubMed 

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