In solid-state NMR, the dipolar-based heteronuclear polarization transfer has been extensively used for sensitivity enhancement and multidimensional correlations, but its efficiency often suffers from undesired spin interactions and hardware limitations. Herein, we propose a novel dipolar-echo edited R-symmetry (DEER) sequence, which is further incorporated into the INEPT-type scheme, dubbed DEER-INEPT, for achieving high efficient heteronuclear polarization transfer. Numerical simulations and NMR experiments demonstrate that DEER-INEPT offers significantly improved robustness, enabling efficient polarization transfer across a wide range of MAS conditions, from slow to ultrafast rates, outperforming existing methods. Its high efficiency leads to noticeably enhanced sensitivity in both 1H→X and X→1H transfers, applicable to both spin-1/2 and spin-half-integer quadrupolar nuclei. DEER-INEPT is expected to be widely used in various systems, offering advantages in both sensitivity enhancement and structural analysis.

This article is Open Access

Please wait while we load your content... Something went wrong. Try again?