Presson AP, Partyka G, Jensen KM, Devine OJ, Rasmussen SA, McCabe LL, McCabe ERB (2013) Current estimate of down syndrome population prevalence in the United States. J Pediatr 163:1163–1168. https://doi.org/10.1016/j.jpeds.2013.06.013
Article PubMed PubMed Central Google Scholar
Thomas MSC, Ojinaga Alfageme O, D’Souza H, Patkee PA, Rutherford MA, Mok KY, Hardy J, Karmiloff-Smith A, LonDown SC (2020) A multi-level developmental approach to exploring individual differences in down syndrome: genes, brain, behaviour, and environment. Res Dev Disabil 104:103638. https://doi.org/10.1016/j.ridd.2020.103638
Article PubMed PubMed Central Google Scholar
Abou-Youssef HS, Kamal MM, Mehaney DA (2014) Triple test screening for down syndrome: an egyptian-tailored study. PLoS ONE 9:e110370–e. https://doi.org/10.1371/journal.pone.0110370
Article CAS PubMed PubMed Central Google Scholar
Temtamy S, Meguid N, Mazen I, Ismail S, Kassem NS, Bassiouni R (1998) Genetic epidemiological study of malformations at birth in Egypt. East Mediterr Health J 4:252–259. https://doi.org/10.26719/1998.4.2.252
Hafez M, El-Tahan M, Zedan M, Eisa M (1984) Demographic trends of Down’s syndrome in Egypt. Hum Biol 56:703–712
Moselhy SS, Alhetari YA, Iyer A, Huwait EA, Al-Ghamdi MA, Al-Ghamdi S, Balamash KS, Basuni AA, Alama MN, Kumosani TA et al (2017) Analysis of SNPs of MC4R, GNB3 and FTO gene polymorphism in obese Saudi subjects. Afr Health Sci 17:1059–1069. https://doi.org/10.4314/ahs.v17i4.14
Article PubMed PubMed Central Google Scholar
Hill DL, Parks EP, Zemel BS, Shults J, Stallings VA, Stettler N (2013) Resting energy expenditure and adiposity accretion among children with Down syndrome: a 3-year prospective study. Eur J Clin Nutr 67:1087–1091. https://doi.org/10.1038/ejcn.2013.137
Article CAS PubMed PubMed Central Google Scholar
Mahmoud R, Kimonis V, Butler MG (2022) Genetics of obesity in humans: a clinical review. Int J Mol Sci 23:11005. https://doi.org/10.3390/ijms231911005
Article CAS PubMed PubMed Central Google Scholar
Bertapelli F, Pitetti K, Agiovlasitis S, Guerra-Junior G (2016) Overweight and obesity in children and adolescents with Down syndrome—prevalence, determinants, consequences, and interventions: a literature review. Res Dev Disabil 57:181–192. https://doi.org/10.1016/j.ridd.2016.06.018
Murray J, Ryan-Krause P (2010) Obesity in children with Down syndrome: background and recommendations for management. Pediatr Nurs 36:314–319
El Saeed GK, Omar MM, Ahmed SE, Omar TA, Shehab-Eldin WA (2022) Fat mass and obesity-associated gene polymorphisms rs9939609 and rs17817449 in type 2 diabetic egyptians. Menoufia Med J 35:991–998. https://doi.org/10.4103/mmj.mmj_46_22
Abdelmajed SS, Youssef M, Zaki ME, Abu-Mandil Hassan N, Ismail S (2017) Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents. Genes Dis 4:170–175. https://doi.org/10.1016/j.gendis.2017.06.002
Article CAS PubMed PubMed Central Google Scholar
Loos RJ, Yeo GS (2014) The bigger picture of FTO—the first GWAS-identified obesity gene. Nat Reviews Endocrinol 10:51–61. https://doi.org/10.1038/nrendo.2013.227
Prakash J, Mittal B, Srivastava A, Awasthi S, Srivastava N (2016) Association of FTO rs9939609 SNP with obesity and obesity- associated phenotypes in a north indian population. Oman Med J 31:99–106. https://doi.org/10.5001/omj.2016.20
Article CAS PubMed PubMed Central Google Scholar
Ursu R, Badiu C, Cucu N, Ursu G, Craciunescu I, Severin E (2015) The study of the rs9939609 FTO gene polymorphism in association with obesity and the management of obesity in a Romanian cohort. J Med Life 8:232
CAS PubMed PubMed Central Google Scholar
Saldaña-Alvarez Y, Salas-Martínez MG, García-Ortiz H, Luckie-Duque A, García-Cárdenas G, Vicenteño-Ayala H, Cordova EJ, Esparza-Aguilar M, Contreras-Cubas C, Carnevale A et al (2016) Gender-dependent association of fto polymorphisms with body mass index in mexicans. PLoS ONE 11:e0145984–e. https://doi.org/10.1371/journal.pone.0145984
Article PubMed PubMed Central Google Scholar
Harbron J, van der Merwe L, Zaahl MG, Kotze MJ, Senekal M (2014) Fat mass and obesity-associated (FTO) gene polymorphisms are associated with physical activity, food intake, eating behaviors, psychological health, and modeled change in body mass index in overweight/obese caucasian adults. Nutrients 6:3130–3152. https://doi.org/10.3390/nu6083130
Article CAS PubMed PubMed Central Google Scholar
Doaei S, Kalantari N, Izadi P, Salonurmi T, Jarrahi AM, Rafieifar S, Azizi Tabesh G, Rahimzadeh G, Gholamalizadeh M, Goodarzi MO (2019) Interactions between macro-nutrients’ intake, FTO and IRX3 gene expression, and FTO genotype in obese and overweight male adolescents. Adipocyte 8:386–391. https://doi.org/10.1080/21623945.2019.1693745
Article CAS PubMed PubMed Central Google Scholar
Isgin-Atici K, Alsulami S, Turan-Demirci B, Surendran S, Sendur SN, Lay I, Karabulut E, Ellahi B, Lovegrove JA, Alikasifoglu M (2021) FTO gene–lifestyle interactions on serum adiponectin concentrations and central obesity in a Turkish population. Int J Food Sci Nutr 72:375–385. https://doi.org/10.1080/09637486.2020.1802580
Article CAS PubMed Google Scholar
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JRB, Elliott KS, Lango H, Rayner NW et al (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316:889–894. https://doi.org/10.1126/science.1141634
Article CAS PubMed PubMed Central Google Scholar
Stratigopoulos G, Burnett LC, Rausch R, Gill R, Penn DB, Skowronski AA, Leduc CA, Lanzano AJ, Zhang P, Storm DR et al (2016) Hypomorphism of Fto and Rpgrip1l causes obesity in mice. J Clin Invest 126:1897–1910. https://doi.org/10.1172/JCI85526
Article PubMed PubMed Central Google Scholar
Eghbali M, Mottaghi A, Taghizadeh S, Cheraghi S (2024) Genetic variants in the fat mass and obesity-associated gene and risk of obesity/overweight in children and adolescents: a systematic review and meta-analysis. Endocrin Diabetes Metab 7:e00510
Barseem NF, El Ella SSA, Tawfik MA, El-Nehrawy RR (2019) The potential implication of fto rs17817449 gene polymorphism on bmi mediated risk for type2 diabetes among obese egyptian children and adolescents. endocrine, metabolic & immune disorders - drug targets. 19:697–704. https://doi.org/10.2174/1871530319666190101124751
Younus LA, Algenabi AHA, Abdul-Zhara MS, Hussein MK (2017) FTO gene polymorphisms (rs9939609 and rs17817449) as predictors of type 2 diabetes Mellitus in obese Iraqi population. Gene 627:79–84. https://doi.org/10.1016/j.gene.2017.06.005
Article CAS PubMed Google Scholar
Przeliorz-Pyszczek A, Regulska-Ilow B (2017) The role of macronutrient intake in reducing the risk of obesity and overweight among carriers of different polymorphisms of FTO gene a review. Rocz Panstw Zakl Hig 68(1):5–13
Almeida SM, Furtado JM, Mascarenhas P, Ferraz ME, Ferreira JC, Monteiro MP, Vilanova M, Ferraz FP (2018) Association between LEPR, FTO, MC4R, and PPARG-2 polymorphisms with obesity traits and metabolic phenotypes in school-aged children. Endocrine 60:466–478. https://doi.org/10.1007/s12020-018-1587-3
Article CAS PubMed PubMed Central Google Scholar
Scott RA, Bailey MES, Moran CN, Wilson RH, Fuku N, Tanaka M, Tsiokanos A, Jamurtas AZ, Grammatikaki E, Moschonis G et al (2010) FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males. Eur J Hum Genet 18:1339–1343. https://doi.org/10.1038/ejhg.2010.131
Article PubMed PubMed Central Google Scholar
Zermeño-Rivera JJ, Astocondor-Pérez JP, Valle Y, Padilla-Gutiérrez JR, Orozco-Castellanos R, Figuera LE, Gutiérrez-Amavizca BE (2014) Association of the FTO gene SNP rs17817449 with body fat distribution in Mexican women. Genet Mol Res 13:8561–8567. https://doi.org/10.4238/2014.february.13.7
留言 (0)