Anastasia Tsiaxerli, Department of Pharmaceutical Technology, Faculty of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Elisavet Vardaka, Department of Pharmaceutical Technology, Faculty of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Christos Moutroupidis, Department of Pharmaceutical Technology, Faculty of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Kevin M.G. Taylor, Department of Pharmaceutics, UCL School of Pharmacy, 29-39 Brunswick Square, London WC1 1AX, UK
Kyriakos Kachrimanis, Department of Pharmaceutical Technology, Faculty of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Maria Malamatari, Department of Pharmacy, School of Health Sciences, Frederick University, Nicosia 1036, CyprusFollow

Downstream processing, Nanoparticle agglomerates, Nanosuspensions, Solidification, Solid oral dosage forms

Pharmaceutical nanosuspensions, also called nanocrystals, are heterogeneous mainly aqueous dispersions of insoluble drug particles stabilised by surfactants and/or polymers. Nanosuspensions as liquid formulations suffer from instability. Solidification of nanosuspensions to solid dosage forms is a way to combine the advantages of nanocrystals with the advantages of the solid state. In this review, advances regarding stabilisation and production of nanosuspensions are briefly covered. Updates on the methods used to convert nanosuspensions to solid oral dosage forms (e.g., powder, granules, pellets, tablets, and films) are presented in depth. From these methods, spray drying and freeze drying are widely used. Granulation and hot-melt extrusion allow straightforward downstream processing, while printing exhibits the potential for dose personalisation. Focus is given on novel formulations (e.g., nano-cocrystals, nanocrystalline solid dispersions) which could further enhance the dissolution and bioavailability of poorly soluble drugs.

Tsiaxerli, Anastasia; Vardaka, Elisavet; Moutroupidis, Christos; Taylor, Kevin M.G.; Kachrimanis, Kyriakos; and Malamatari, Maria (2024) "Updates on the conversion of nanosuspensions to solid oral dosage forms," Journal of Food and Drug Analysis: Vol. 32 : Iss. 4 , Article 2.
Available at: https://doi.org/10.38212/2224-6614.3525

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