Adams JE 3rd, Bodor GS, Davila-Roman VG, Delmez JA, Apple FS, Ladenson JH, Jaffe AS (1993) Cardiac troponin I: a marker with high specificity for cardiac injury. Circulation 88(1):101–106

Article  PubMed  Google Scholar 

Álvarez-Benedicto E, Farbiak L, Ramírez MM, Wang X, Johnson LT, Mian O, Siegwart DJ (2022) Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA). Biomater Sci 10(2):549–559

Article  PubMed  PubMed Central  Google Scholar 

Bach M-A (1977) Lymphocyte-mediated cytotoxicity: effects of ageing, adult thymectomy and thymic factor. J Immunol 119(2):641–647

Article  CAS  PubMed  Google Scholar 

Baiersdörfer M, Boros G, Muramatsu H, Mahiny A, Vlatkovic I, Sahin U, Karikó K (2019) A facile method for the removal of dsRNA contaminant from in vitro-transcribed mRNA. Mol Ther Nucleic Acids 15:26–35. https://doi.org/10.1016/j.omtn.2019.02.018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bodey B, Bodey B Jr, Siegel S, Kaiser H (1997) Involution of the mammalian thymus, one of the leading regulators of aging. In Vivo (Athens, Greece) 11(5):421–440

CAS  PubMed  Google Scholar 

Bozkurt B, Kamat I, Hotez PJ (2021) Myocarditis with COVID-19 mRNA vaccines. Circulation 144(6):471–484

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brito S, Ferreira N, Mateus S, Bernardo M, Pinto B, Lourenço A, Grenho F (2021) A case of autoimmune hemolytic anemia following COVID-19 messenger ribonucleic acid vaccination. Cureus. https://doi.org/10.7759/cureus.15035

Article  PubMed  PubMed Central  Google Scholar 

Broudic K, Laurent S, Perkov V, Simon C, Garinot M, Truchot N, Désert P (2023) Nonclinical safety assessment of an mRNA COVID-19 vaccine candidate following repeated administrations and biodistribution. J Appl Toxicol 44(3):371–390

Article  PubMed  Google Scholar 

Carlson RJ, Navone A, McConnell JP, Burritt M, Castle MC, Grill D, Jaffe AS (2002) Effect of myocardial ischemia on cardiac troponin I and T. Am J Cardiol 89(2):224–226

Article  CAS  PubMed  Google Scholar 

Chaudhary N, Weissman D, Whitehead KA (2021ba) mRNA vaccines for infectious diseases: principles, delivery and clinical translation. Nat Rev Drug Discov 20(11):817–838. https://doi.org/10.1038/s41573-021-00283-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen H, Ren X, Xu S, Zhang D, Han T (2022) Optimization of lipid nanoformulations for effective mRNA delivery. Int J Nanomed 17:2893–2905

Article  Google Scholar 

Donahue DA, Ballesteros C, Maruggi G, Glover C, Ringenberg MA, Marquis M, Stokes AH (2023) Nonclinical safety assessment of lipid nanoparticle-and emulsion-based self-amplifying mRNA vaccines in rats. Int J Toxicol 42(1):37–49

Article  CAS  PubMed  Google Scholar 

Dortant P, Peters-Volleberg G, Van Loveren H, Marquardt R, Speijers G (2001) Age-related differences in the toxicity of ochratoxin A in female rats. Food Chem Toxicol 39(1):55–65

Article  CAS  PubMed  Google Scholar 

El Sahly HM, Baden LR, Essink B, Doblecki-Lewis S, Martin JM, Anderson EJ, Fichtenbaum CJ (2021) Efficacy of the mRNA-1273 SARS-CoV-2 vaccine at completion of blinded phase. N Engl J Med 385(19):1774–1785

Article  PubMed  Google Scholar 

Elia U, Rotem S, Bar-Haim E, Ramishetti S, Naidu GS, Gur D, Alcalay R (2021) Lipid nanoparticle RBD-hFc mRNA vaccine protects hACE2 transgenic mice against a lethal SARS-CoV-2 infection. Nano Lett 21(11):4774–4779

Article  CAS  PubMed  Google Scholar 

Ermilova I, Swenson J (2020) DOPC versus DOPE as a helper lipid for gene-therapies: molecular dynamics simulations with DLin-MC3-DMA. Phys Chem Chem Phys 22(48):28256–28268

Article  CAS  PubMed  Google Scholar 

FDA (2022) Summary basis for regulatory action. BLA/NDA STN : STN 125752/0

FDA (2022) Toxicology review of COVID-19 vaccine (BNT162, PF-07302048, Final Report), BLA 125742

Feng Y-J, Chen C, Fallon JT, Lai T, Chen L, Knibbs DR, Wu AH (1998) Comparison of cardiac troponin I, creatine kinase-MB, and myoglobin for detection of acute ischemic myocardial injury in a swine model. Am J Clin Pathol 110(1):70–77

Article  CAS  PubMed  Google Scholar 

Fischinger S, Boudreau CM, Butler AL, Streeck H, Alter G (2019) Sex differences in vaccine-induced humoral immunity. Semin Immunopathol 41:239–249

Article  CAS  PubMed  Google Scholar 

Franks ME, Macpherson GR, Figg WD (2004) Thalidomide. The Lancet 363(9423):1802–1811

Article  CAS  Google Scholar 

Gadi SR, Brunker PA, Al-Samkari H, Sykes DB, Saff RR, Lo J, Leaf RK (2021) Severe autoimmune hemolytic anemia following receipt of SARS-CoV-2 mRNA vaccine. Transfusion 61(11):3267–3271

Article  CAS  PubMed  PubMed Central  Google Scholar 

García-Grimshaw M, Michel-Chávez A, Vera-Zertuche JM, Galnares-Olalde JA, Hernández-Vanegas LE, Figueroa-Cucurachi M, Arauz A (2021) Guillain-Barré syndrome is infrequent among recipients of the BNT162b2 mRNA COVID-19 vaccine. Clin Immunol 230:108818

Article  PubMed  PubMed Central  Google Scholar 

Gibson EA, Li H, Fruh V, Gabra M, Asokan G, Jukic AMZ, Onnela J-P (2022) COVID-19 vaccination and menstrual cycle length in the Apple Women’s Health Study. Npj Digit Med 5(1):165

Article  PubMed  PubMed Central  Google Scholar 

Granados-Riveron JT, Aquino-Jarquin G (2021) Engineering of the current nucleoside-modified mRNA-LNP vaccines against SARS-CoV-2. Biomed Pharmacother 142:111953

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gregersen CH, Mearraoui R, Søgaard PP, Clergeaud G, Petersson K, Urquhart AJ, Simonsen JB (2024) Lipid nanoparticles containing labile PEG-lipids transfect primary human skin cells more efficiently in the presence of apoE. Eur J Pharm Biopharm 197:114219

Article  CAS  PubMed  Google Scholar 

Greinacher A, Selleng K, Mayerle J, Palankar R, Wesche J, Reiche S, Thiele T (2021) Anti-SARS-CoV-2 spike protein and anti-platelet factor 4 antibody responses induced by COVID-19 disease and ChAdOx1 nCov-19 vaccination

Grimaldi-Bensouda L, Michel M, Aubrun E, Leighton P, Viallard JF, Adoue D, Godeau B (2012) A case-control study to assess the risk of immune thrombocytopenia associated with vaccines. Blood, J Am Soc Hematol 120(25):4938–4944

CAS  Google Scholar 

Hajj KA, Melamed JR, Chaudhary N, Lamson NG, Ball RL, Yerneni SS, Whitehead KA (2020) A potent branched-tail lipid nanoparticle enables multiplexed mRNA delivery and gene editing in vivo. Nano Lett 20(7):5167–5175

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hajjo R, Momani E, Sabbah DA, Baker N, Tropsha A (2023) Identifying a causal link between prolactin signaling pathways and COVID-19 vaccine-induced menstrual changes. Npj Vaccines 8(1):129

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hally KE, La Flamme AC, Larsen PD, Harding SA (2017) Platelet Toll-like receptor (TLR) expression and TLR-mediated platelet activation in acute myocardial infarction. Thromb Res 158:8–15

Article  CAS  PubMed  Google Scholar 

Hamiel U, Kventsel I, Youngster I (2016) Recurrent immune thrombocytopenia after influenza vaccination: a case report. Pediatrics. https://doi.org/10.1542/peds.2016-0124

Article  PubMed  Google Scholar 

Hanson KE, Goddard K, Lewis N, Fireman B, Myers TR, Bakshi N, Xu S (2022) Incidence of Guillain-Barré syndrome after COVID-19 vaccination in the vaccine safety datalink. JAMA Netw Open 5(4):e228879–e228879

Article  PubMed  PubMed Central  Google Scholar 

Henri O, Pouehe C, Houssari M, Galas L, Nicol L, Edwards-Lévy F,