Stepwise molecular specification of excitatory synapse diversity onto cerebellar Purkinje cells

Sanes, J. R. & Zipursky, S. L. Synaptic specificity, recognition molecules, and assembly of neural circuits. Cell 181, 536–556 (2020).

Article  CAS  PubMed  Google Scholar 

Cizeron, M. et al. A brainwide atlas of synapses across the mouse life span. Science 369, 270–275 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu, F. et al. Architecture of the mouse brain synaptome. Neuron 99, 781–799 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sanes, J. R. & Yamagata, M. Many paths to synaptic specificity. Annu. Rev. Cell Dev. Biol. 25, 161–195 (2009).

Article  CAS  PubMed  Google Scholar 

De Wit, J. & Ghosh, A. Specification of synaptic connectivity by cell surface interactions. Nat. Rev. Neurosci. 17, 22–35 (2016).

PubMed  Google Scholar 

Hassan, B. A. & Hiesinger, P. R. Beyond molecular codes: simple rules to wire complex brains. Cell 163, 285–291 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Südhof, T. C. Towards an understanding of synapse formation. Neuron 100, 276–293 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Changeux, J.-P. & Danchin, A. Selective stabilisation of developing synapses as a mechanism for the specification of neuronal networks. Nature 264, 705–712 (1976).

Article  CAS  PubMed  Google Scholar 

Sperry, R. W. Chemoaffinity in the orderly growth of nerve fiber patterns and connections. Proc. Natl Acad. Sci. USA 50, 703–710 (1963).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schroeder, A. et al. A modular organization of LRR protein-mediated synaptic adhesion defines synapse identity. Neuron 99, 329–344 (2018).

Article  CAS  PubMed  Google Scholar 

Sigoillot, S. M. et al. The secreted protein C1QL1 and its receptor BAI3 control the synaptic connectivity of excitatory inputs converging on cerebellar Purkinje cells. Cell Rep. 10, 820–832 (2015).

Article  CAS  PubMed  Google Scholar 

Uemura, T. et al. Trans-synaptic interaction of GluRδ2 and neurexin through Cbln1 mediates synapse formation in the cerebellum. Cell 141, 1068–1079 (2010).

Article  CAS  PubMed  Google Scholar 

Früh, S. et al. Neuronal dystroglycan is necessary for formation and maintenance of functional CCK-positive basket cell terminals on pyramidal cells. J. Neurosci. 36, 10296–10313 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Fossati, M. et al. Trans-synaptic signaling through the glutamate receptor δ-1 mediates inhibitory synapse formation in cortical pyramidal neurons. Neuron 104, 1081–1094 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heller, E. A. et al. The biochemical anatomy of cortical inhibitory synapses. PLoS ONE 7, e39572 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Selimi, F., Cristea, I. M., Heller, E., Chait, B. T. & Heintz, N. Proteomic studies of a single CNS synapse type: the parallel fiber/Purkinje cell synapse. PLoS Biol. 7, e1000083 (2009).

Article  PubMed  PubMed Central  Google Scholar 

Matsuda, K. et al. Cbln1 is a ligand for an orphan glutamate receptor δ2, a bidirectional synapse organizer. Science 328, 363–368 (2010).

Article  CAS  PubMed  Google Scholar 

Favuzzi, E. et al. Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits. Science 363, 413–417 (2019).

Article  CAS  PubMed  Google Scholar 

Ito, M. Control of mental activities by internal models in the cerebellum. Nat. Rev. Neurosci. 9, 304–313 (2008).

Article  CAS  PubMed  Google Scholar 

Buckner, R. L. The cerebellum and cognitive function: 25 years of insight from anatomy and neuroimaging. Neuron 80, 807–815 (2013).

Article  CAS  PubMed  Google Scholar 

Konnerth, A., Llano, I. & Armstrong, C. M. Synaptic currents in cerebellar Purkinje cells. Proc. Natl Acad. Sci. USA 87, 2662–2665 (1990).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ito, M. & Kano, M. Long-lasting depression of parallel fiber-Purkinje cell transmission induced by conjunctive stimulation of parallel fibers and climbing fibers in the cerebellar cortex. Neurosci. Lett. 33, 253–258 (1982).

Article  CAS  PubMed  Google Scholar 

Ichikawa, R. et al. Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination. Proc. Natl Acad. Sci. USA 113, 2282–2287 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hirai, H. et al. Cbln1 is essential for synaptic integrity and plasticity in the cerebellum. Nat. Neurosci. 8, 1534–1541 (2005).

Article  CAS  PubMed  Google Scholar 

Elegheert, J. et al. Structural basis for integration of GluD receptors within synaptic organizer complexes. Science 353, 295–299 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kakegawa, W. et al. Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum. Neuron 85, 316–329 (2015).

Article  CAS  PubMed  Google Scholar 

Ito-Ishida, A. et al. Cbln1 regulates rapid formation and maintenance of excitatory synapses in mature cerebellar Purkinje cells in vitro and in vivo. J. Neurosci. 28, 5920–5930 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Veleanu, M. et al. Modified climbing fiber/Purkinje cell synaptic connectivity in the cerebellum of the neonatal phencyclidine model of schizophrenia. Proc. Natl Acad. Sci. USA 119, e2122544119 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sotelo, C. Cellular and genetic regulation of the development of the cerebellar system. Prog. Neurobiol. 72, 295–339 (2004).

Article  CAS  PubMed  Google Scholar 

Kano, M., Watanabe, T., Uesaka, N. & Watanabe, M. Multiple phases of climbing fiber synapse elimination in the developing cerebellum. Cerebellum 17, 722–734 (2018).

Article  PubMed  Google Scholar 

Kita, Y., Tanaka, K. & Murakami, F. Specific labeling of climbing fibers shows early synaptic interactions with immature Purkinje cells in the prenatal cerebellum. Dev. Neurobiol. 75, 927–934 (2015).

Article  CAS  PubMed 

留言 (0)

沒有登入
gif