Zijlstra, A. & Di Vizio, D. Size matters in nanoscale communication. Nat. Cell Biol. 20, 228–230 (2018).
Article CAS PubMed PubMed Central Google Scholar
Zhang, H. et al. Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Nat. Cell Biol. 20, 332–343 (2018).
Article CAS PubMed PubMed Central Google Scholar
Zhang, Q. et al. Transfer of functional cargo in exomeres. Cell Rep 27, 940–954 (2019).
Article CAS PubMed PubMed Central Google Scholar
Jeppesen, D. K. et al. Reassessment of exosome composition. Cell 177, 428–445 (2019).
Article CAS PubMed PubMed Central Google Scholar
Lucotti, S., Kenific, C. M., Zhang, H. & Lyden, D. Extracellular vesicles and particles impact the systemic landscape of cancer. EMBO J. 41, e109288 (2022).
Article CAS PubMed PubMed Central Google Scholar
Costa-Silva, B. et al. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nat. Cell Biol. 17, 816–826 (2015).
Article CAS PubMed PubMed Central Google Scholar
Rodrigues, G. et al. Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. Nat. Cell Biol. 21, 1403–1412 (2019).
Article CAS PubMed PubMed Central Google Scholar
Peinado, H. et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat. Med. 18, 883–891 (2012).
Article CAS PubMed PubMed Central Google Scholar
Hoshino, A. et al. Tumour exosome integrins determine organotropic metastasis. Nature 527, 329–335 (2015).
Article CAS PubMed PubMed Central Google Scholar
Abdouh, M. et al. Exosomes isolated from cancer patients’ sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells. J. Exp. Clin. Cancer Res. 36, 113 (2017).
Article PubMed PubMed Central Google Scholar
Clancy, J. W., Sheehan, C. S., Boomgarden, A. C. & D’Souza-Schorey, C. Recruitment of DNA to tumor-derived microvesicles. Cell Rep. 38, 110443 (2022).
Article CAS PubMed PubMed Central Google Scholar
Kahlert, C. et al. Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and P53 DNA in the serum exosomes of patients with pancreatic cancer. J. Biol. Chem. 289, 3869–3875 (2014).
Article CAS PubMed PubMed Central Google Scholar
Thakur, B. K. et al. Double-stranded DNA in exosomes: a novel biomarker in cancer detection. Cell Res. 24, 766–769 (2014).
Article CAS PubMed PubMed Central Google Scholar
Fischer, S. et al. Indication of horizontal DNA gene transfer by extracellular vesicles. PLoS ONE 11, e0163665 (2016).
Article PubMed PubMed Central Google Scholar
Lazaro-Ibanez, E. et al. DNA analysis of low- and high-density fractions defines heterogeneous subpopulations of small extracellular vesicles based on their DNA cargo and topology. J. Extracell. Vesicles 8, 1656993 (2019).
Article CAS PubMed PubMed Central Google Scholar
Maire, C. L. et al. Genome-wide methylation profiling of glioblastoma cell-derived extracellular vesicle DNA allows tumor classification. Neuro Oncol. 23, 1087–1099 (2021).
Article CAS PubMed PubMed Central Google Scholar
Nemeth, A. et al. Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. Sci. Rep. 7, 8202 (2017).
Article PubMed PubMed Central Google Scholar
Choi, D. et al. Mapping subpopulations of cancer cell-derived extracellular vesicles and particles by nano-flow cytometry. ACS Nano 13, 10499–10511 (2019).
Article CAS PubMed Google Scholar
Fernando, M. R., Jiang, C., Krzyzanowski, G. D. & Ryan, W. L. New evidence that a large proportion of human blood plasma cell-free DNA is localized in exosomes. PLoS ONE 12, e0183915 (2017).
Article PubMed PubMed Central Google Scholar
Lazaro-Ibanez, E. et al. Different gDNA content in the subpopulations of prostate cancer extracellular vesicles: apoptotic bodies, microvesicles, and exosomes. Prostate 74, 1379–1390 (2014).
Article CAS PubMed PubMed Central Google Scholar
Torralba, D. et al. Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts. Nat. Commun. 9, 2658 (2018).
Article PubMed PubMed Central Google Scholar
Vagner, T. et al. Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma. J. Extracell. Vesicles 7, 1505403 (2018).
Article CAS PubMed PubMed Central Google Scholar
Bernard, V. et al. Circulating nucleic acids are associated with outcomes of patients with pancreatic cancer. Gastroenterology 156, 108–118 (2019).
Article CAS PubMed Google Scholar
Yang, S. et al. Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer. Cancer Biol. Ther. 18, 158–165 (2017).
Article CAS PubMed PubMed Central Google Scholar
Choi, J. et al. Detection of circulating KRAS mutant DNA in extracellular vesicles using droplet digital PCR in patients with colon cancer. Front. Oncol. 12, 1067210 (2022).
Article CAS PubMed PubMed Central Google Scholar
Cai, J. et al. SRY gene transferred by extracellular vesicles accelerates atherosclerosis by promotion of leucocyte adherence to endothelial cells. Clin. Sci. (Lond.) 129, 259–269 (2015).
Article CAS PubMed Google Scholar
Sansone, P. et al. Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer. Proc. Natl Acad. Sci. USA 114, E9066–E9075 (2017).
Article CAS PubMed PubMed Central Google Scholar
Ghanam, J. et al. Extracellular vesicles transfer chromatin-like structures that induce non-mutational dysfunction of p53 in bone marrow stem cells. Cell Discov. 9, 12 (2023).
Article CAS PubMed PubMed Central Google Scholar
Lian, Q. et al. Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation. Cell Res. 27, 784–800 (2017).
留言 (0)