Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression

Zijlstra, A. & Di Vizio, D. Size matters in nanoscale communication. Nat. Cell Biol. 20, 228–230 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, H. et al. Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Nat. Cell Biol. 20, 332–343 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, Q. et al. Transfer of functional cargo in exomeres. Cell Rep 27, 940–954 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jeppesen, D. K. et al. Reassessment of exosome composition. Cell 177, 428–445 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lucotti, S., Kenific, C. M., Zhang, H. & Lyden, D. Extracellular vesicles and particles impact the systemic landscape of cancer. EMBO J. 41, e109288 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Costa-Silva, B. et al. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nat. Cell Biol. 17, 816–826 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rodrigues, G. et al. Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. Nat. Cell Biol. 21, 1403–1412 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peinado, H. et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat. Med. 18, 883–891 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hoshino, A. et al. Tumour exosome integrins determine organotropic metastasis. Nature 527, 329–335 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abdouh, M. et al. Exosomes isolated from cancer patients’ sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells. J. Exp. Clin. Cancer Res. 36, 113 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Clancy, J. W., Sheehan, C. S., Boomgarden, A. C. & D’Souza-Schorey, C. Recruitment of DNA to tumor-derived microvesicles. Cell Rep. 38, 110443 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kahlert, C. et al. Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and P53 DNA in the serum exosomes of patients with pancreatic cancer. J. Biol. Chem. 289, 3869–3875 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thakur, B. K. et al. Double-stranded DNA in exosomes: a novel biomarker in cancer detection. Cell Res. 24, 766–769 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fischer, S. et al. Indication of horizontal DNA gene transfer by extracellular vesicles. PLoS ONE 11, e0163665 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Lazaro-Ibanez, E. et al. DNA analysis of low- and high-density fractions defines heterogeneous subpopulations of small extracellular vesicles based on their DNA cargo and topology. J. Extracell. Vesicles 8, 1656993 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maire, C. L. et al. Genome-wide methylation profiling of glioblastoma cell-derived extracellular vesicle DNA allows tumor classification. Neuro Oncol. 23, 1087–1099 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nemeth, A. et al. Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. Sci. Rep. 7, 8202 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Choi, D. et al. Mapping subpopulations of cancer cell-derived extracellular vesicles and particles by nano-flow cytometry. ACS Nano 13, 10499–10511 (2019).

Article  CAS  PubMed  Google Scholar 

Fernando, M. R., Jiang, C., Krzyzanowski, G. D. & Ryan, W. L. New evidence that a large proportion of human blood plasma cell-free DNA is localized in exosomes. PLoS ONE 12, e0183915 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Lazaro-Ibanez, E. et al. Different gDNA content in the subpopulations of prostate cancer extracellular vesicles: apoptotic bodies, microvesicles, and exosomes. Prostate 74, 1379–1390 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Torralba, D. et al. Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts. Nat. Commun. 9, 2658 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Vagner, T. et al. Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma. J. Extracell. Vesicles 7, 1505403 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bernard, V. et al. Circulating nucleic acids are associated with outcomes of patients with pancreatic cancer. Gastroenterology 156, 108–118 (2019).

Article  CAS  PubMed  Google Scholar 

Yang, S. et al. Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer. Cancer Biol. Ther. 18, 158–165 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi, J. et al. Detection of circulating KRAS mutant DNA in extracellular vesicles using droplet digital PCR in patients with colon cancer. Front. Oncol. 12, 1067210 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai, J. et al. SRY gene transferred by extracellular vesicles accelerates atherosclerosis by promotion of leucocyte adherence to endothelial cells. Clin. Sci. (Lond.) 129, 259–269 (2015).

Article  CAS  PubMed  Google Scholar 

Sansone, P. et al. Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer. Proc. Natl Acad. Sci. USA 114, E9066–E9075 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghanam, J. et al. Extracellular vesicles transfer chromatin-like structures that induce non-mutational dysfunction of p53 in bone marrow stem cells. Cell Discov. 9, 12 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lian, Q. et al. Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation. Cell Res. 27, 784–800 (2017).

Article  CAS  PubMed 

留言 (0)

沒有登入
gif