Front. Cell Dev. Biol.

Sec. Cell Death and Survival

Volume 12 - 2024 | doi: 10.3389/fcell.2024.1492870

This article is part of the Research Topic Role and Mechanism of Regulated Cell Death in Musculoskeletal Development, Homeostasis, and Diseases View all 3 articles

Provisionally accepted

Hantao Yang 1 Xuandu Chen 1 Jun Chen 2 Yansong Dong 1 Yafang Huang 1,2 Lei Qin 1* Jie Tan 1,2* Weihong Yi 1 1 Shenzhen Sixth People's Hospital, Shenzhen, Hong Kong Region, China 2 Department of Orthopaedics, Wuhan Fourth Hospital, Wuhan, China

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Intervertebral disc degeneration (IVDD) is the leading cause of low back pain, where degeneration and death of nucleus pulposus cells within the intervertebral disc (IVD) can be obviously revealed.This degeneration can result in an imbalance in the extracellular matrix due to the loss of proteoglycans and water content, which can further lead to catabolic and anabolic dysfunction of the IVD. Recently, the dysfunction of cartilage endplate (CEP) during aging has drawn large attention due to its essential functions in contributing nutrient exchange and maintaining IVD homeostasis. Furthermore, the inflammation and disturbed homeostasis of CEP not only accelerate the degradation of nucleus pulposus extracellular matrix, but also exacerbate IVDD by causing nucleus pulposus cell death through other pathological factors. Here in this review, we summarized the possible pathological factors and the underlying mechanisms of the CEP inflammation-induced IVDD, including exosomes degeneration, CEP calcification, ferroptosis, mechanical changes, and cell senescence. Besides, changes of miRNAs, pain-related neural reflex arc and pathways associated with CEP inflammation-induced IVDD are also reviewed. In addition, new strategies specifically designed for CEP inflammation-induced IVDD are also discussed in the last section. We hope this paper can not only offer some new insights for advancing novel strategies for treating IVDD, but also serve as a valuable reference for researchers in this field.

Keywords: Intervertebral disc degeneration 1, Cartilage endplate 2, Inflammation 3, exosomes 4, Calcification 5, Ferroptosis 6, Senescence 7

Received: 08 Sep 2024; Accepted: 21 Nov 2024.

Copyright: © 2024 Yang, Chen, Chen, Dong, Huang, Qin, Tan and Yi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Lei Qin, Shenzhen Sixth People's Hospital, Shenzhen, Hong Kong Region, China
Jie Tan, Shenzhen Sixth People's Hospital, Shenzhen, Hong Kong Region, China

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