Front. Cell. Infect. Microbiol.

Sec. Intestinal Microbiome

Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1491639

Provisionally accepted

Qiong Wang 1 Zi-Hang Yu 2 Liang Nie 2 Feixiang Wang 3 Guo Mu 4 Bin Lu 1* 1 Department of Anesthesiology, Zigong Fourth People's Hospital, Zigong, Sichuan, 643000, China, Zigong, Sichuan Province, China 2 Fushun County People's Hospital, Fushun, Sichuan, China 3 Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, 646000, China, Luzhou, Sichuan Province, China 4 Zigong Fourth People's Hospital, Zigong, China

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Ischemia-reperfusion injury (IRI) is a common and clinically significant form of tissue damage encountered in medical practice. This pathological process has been thoroughly investigated across a variety of clinical settings, including, but not limited to, sepsis, organ transplantation, shock, myocardial infarction, cerebral ischemia, and stroke. Intestinal IRI, in particular, is increasingly recognized as a significant clinical entity due to marked changes in the gut microbiota and their metabolic products, often described as the body's "second genome." These changes in intestinal IRI lead to profound alterations in the gut microbiota and their metabolic outputs, impacting not only the pathology of intestinal IRI itself but also influencing the function of other organs through various mechanisms. Notable among these are brain, liver, and kidney injuries, with acute lung injury being especially significant. This review seeks to explore in depth the roles and mechanisms of the gut microbiota and their metabolic products in the progression of acute lung injury initiated by intestinal IRI, aiming to provide a theoretical basis and directions for future research into the treatment of related conditions.

Keywords: gut, microbiota, ischemia-reperfusion injury, Intestinal ischemia-reperfusion injury, Acute Lung Injury

Received: 05 Sep 2024; Accepted: 15 Nov 2024.

Copyright: © 2024 Wang, Yu, Nie, Wang, Mu and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Bin Lu, Department of Anesthesiology, Zigong Fourth People's Hospital, Zigong, Sichuan, 643000, China, Zigong, Sichuan Province, China

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