Kim et al.15 2023 Prospective, RCT, Jan. 2018 to Feb. 2021, multicenter, Korea 161 166 63.5±11.1 62.0±10.5 102/51 111/55 215 (6–8 mm, 155; 9–10 mm, 60) 210 (6–8 mm, 169; 9–10 mm, 41) 7.0±1.2 7.2±1.4 Cecum/ascending 63 (29.3); HFa/transverse/SFb 73 (34.0); descending/sigmoid 66 (30.7); rectum 13 (6.0) Cecum/ascending 67 (31.9); HFa/transverse/SFb 50 (23.8); descending/sigmoid 80 (38.1); rectum 13 (6.2) Tubular adenoma 196 (91.2); hyperplastic polyp 14 (6.5); serrated polyp 5 (2.3); adenocarcinoma 0 (0) Tubular adenoma 186 (88.6); hyperplastic polyp 16 (7.6); serrated polyp 5 (2.4); adenocarcinoma 3 Traditional oval snare Normal saline solution mixed with indigo carmine (0.04%) and epinephrine (1:10,000) Katagiri et al.14 2023 Prospective RCT, Apr. 2019 to Apr. 2021, single-center, Japan 59 59 63.7±13.3 67.9±10.2 36/23 33/26 <5 mm, 76 (67.9%); ≥5 mm, 36 (32.1%) <5 mm, 91 (61.1%); ≥5 mm, 58 (38.9%) 4.2±1.8 4.4±1.8 Right side 73 (65.2%); left side 39 (34.8%) Right side 108 (72.5%); left side 41 (27.5%) Low-grade adenoma 86 (76.8%); high grade adenoma 0 (0%); sessile serrated adenoma/polyp 10 (8.9%); hyperplastic polyp 13 (11.6%); inflammatory polyp 3 (2.7%); loss of tissue 0 (0%) Low-grade adenoma 110 (73.8%); high grade adenoma 1 (0.7); sessile serrated adenoma/polyp 7 (4.7%); hyperplastic polyp 29 (19.5%); inflammatory polyp 1 (0.7%); loss of tissue 1 (0.7%) NR Epinephrine (0.001%)-added saline Li et al.16 2020 Prospective, RCT, Jul. 2017 and Mar. 2019, single-center, China 131 135 51.63±14.40 51.77±14.55 77/52 73/59 244 252 11.95±3.35 12.03±3.36 Caecum and ascending colon 57/88; transverse colon 54/61; descending colon 46/50; sigmoid colon and rectum 42/45 Caecum and ascending colon 68/75; transverse colon 54/58; descending colon 57/59; sigmoid colon and rectum 57/58 Submucosal adenocarcinoma 0; advanced adenoma 123/159; adenoma 60/64; sessile/traditional serrated adenoma 16/21 Submucosal adenocarcinoma 1/1; advanced adenoma 160/171; adenoma 59/61; sessile/traditional serrated adenoma 17/19 Snares (Boston Scientific CAPTIVATORTM 13 mm; JHY-SD-23-230-15-AI 15 mm) Normal saline solution, epinephrine (1:10 0000), and methylene blue Mou et al.13 2023 RCT, Jul. 2020 to Sep. 2020, multicenter, China 150 150 53 (11, 18–79) 54 (10, 28–74) 90/60 92/58 216 (3–5 mm, 139 [64.4%]; 6–9 mm, 77 [35.6%]) 150 (3–5 mm, 146 [62.4%], 6–9 mm, 88 [37.6%]) 5 (2, 3–8) 5 (2, 3–9) Cecum 7; ascending colon 27; hepatic flexure 14; transverse colon 41; splenic flexure 0; descending colon 24; sigmoid colon 72; rectum 31 Cecum 9; ascending colon 35; hepatic flexure 14; transverse colon 53; splenic flexure 3; descending colon 35; sigmoid colon 50; rectum 35 Tubular adenoma 136; villous/tubulovillous adenoma 6; sessile serrated lesion 4; hyperplastic polyp 53; inflammatory polyp 14 Tubular adenoma 146; villous/tubulovillous adenoma 6; sessile serrated lesion 8; hyperplastic polyp 51; inflammatory polyp 22 CSP-dedicated or traditional snares Saline solution mixed with methylene blue and epinephrine Rex et al.12 2022 Prospective, RCT, Aug. 10, 2018 and Mar. 26, 2021, multicenter, USA 59 63 66.2 (9.9) 65.0 (8.0) 25/34 28/35 68 82 9.4±3.1 9.5±2.8 Ascending colon 24 (35.3); cecum 7 (10.3); descending colon 8 (11.8); hepatic flexure 5 (7.4); ileocecal valve 1 (1.5); rectum 2 (2.9); sigmoid colon 3 (4.4); transverse colon 18 (26.5) Ascending colon 26 (31.7); cecum 8 (9.8); descending colon 13 (15.9); hepatic flexure 3 (3.7); ileocecal valve 0 (0); rectum 1 (1.2); sigmoid colon 6 (7.3); transverse colon 25 (30.5) Adenoma 53 (77.9); hyperplastic 3 (4.4); normal mucosa 1 (1.5); sessile serrated lesion 10 (14.7); no tissue 1 (1.5) Adenoma 61 (74.4); hyperplastic 2 (2.4); normal mucosa 0 (0); sessile serrated lesion 19 (23.2); no tissue 0 (0) Dedicated cold snare (Boston CapCold [Boston Scientific] or Exacto Cold Snare [Steris Corporation) Saline solution, hydroxyethyl starch, or any commercially available injection fluid Shimodate et al.6 2020 Prospective RCT, Nov. 2017 to Sep. 2019, single-center, Japan 107 107 68 (median) 65 (median) 60/47 61/46 97 100 5 mm (median) 5 mm (median) Cecum 4; ascending colon 23; transverse colon 23; descending colon 10; sigmoid colon 30; rectum 7 Cecum 5; ascending colon 24; transverse colon 15; descending colon 14; sigmoid colon 34; rectum 8 Low-grade adenoma 92; high grade adenoma 0; sessile serrated adenoma/polyp 2; hyperplastic polyp 1; inflammatory polyp 1; adenocarcinoma 1 Low-grade adenoma 95; high grade adenoma 1; sessile serrated adenoma/polyp 1; hyperplastic polyp 1; inflammatory polyp 2; adenocarcinoma 0 Cold polypectomy snare (Exacto cold snare) or SnareMaster plus Normal saline solution mixed with indigo carmine (.04%) and epinephrine Wei et al.9 2022 Prospective, RCT, Sep. 16, 2020, and May 31, 2021, single-center, USA 105 109 68.7 (7.8) 68.9 (7.9) 107/2 102/3 149 142 5.3 (1.5) 5.3 (1.5) Cecum 13; ascending 42; hepatic flexure 7; transverse 50; descending 14; sigmoid 20; rectum 3 Cecum 13; ascending, 39; hepatic flexure 5; transverse 48; descending, 19; sigmoid 14; rectum 4 NR NR Open Exacto cold snare Everlift injection