Effectiveness and safety of remimazolam tosilate versus propofol for sedation in patients undergoing gastrointestinal endoscopy: a randomized controlled trial

Hu B, Jiang K, Shi W, et al. Effect of remimazolam tosilate on respiratory depression in elderly patients undergoing gastroscopy: a multicentered, prospective, and randomized study. Drug Des Dev Ther. 2022;16:4151–9. https://doi.org/10.2147/DDDT.S391147.

Article  Google Scholar 

Shen XC, Ao X, Cao Y, et al. Etomidate-remifentanil is more suitable for monitored anesthesia care during gastroscopy in older patients than propofol-remifentanil. Med Sci Monit. 2015;21:1–8. https://doi.org/10.12659/MSM.891183.

PubMed  PubMed Central  CAS  Google Scholar 

Zhou S, Zhu Z, Dai W, et al. National survey on sedation for gastrointestinal endoscopy in 2758 Chinese hospitals. Br J Anaesth. 2021;127(1):56–64. https://doi.org/10.1016/j.bja.2021.01.028.

Article  PubMed  CAS  Google Scholar 

Zhu Q, Luo Z, Wang X, et al. Efficacy and safety of ciprofol versus propofol for the induction of anesthesia in adult patients: a multicenter phase 2a clinical trial. Int J Clin Pharm. 2023;45(2):473–82. https://doi.org/10.1007/s11096-022-01529-x.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kang S, Hu L, Zhang B, et al. Efficacy, safety, and postoperative fatigue syndrome in combined alfentanil and propofol for patients with simple snoring undergoing gastroscopy with conscious or deep sedation levels. Asian J Surg. 2023;46(12):5605–6. https://doi.org/10.1016/j.asjsur.2023.08.013.

Article  PubMed  Google Scholar 

Nakatsuka M, MacLeod AD. Hemodynamic and respiratory effects of transtracheal high-frequency jet ventilation during difficult intubation. J Clin Anesth. 1992;4(4):321–4. https://doi.org/10.1016/0952-8180(92)90138-q.

Article  PubMed  CAS  Google Scholar 

Chen J, Zou X, Hu B, et al. Remimazolam vs etomidate: haemodynamic effects in hypertensive elderly patients undergoing non-cardiac surgery. Drug Des Devel Ther. 2023;17:2943–53. https://doi.org/10.2147/DDDT.S425590.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhao TY, Chen D, Sun H, et al. Moderate sedation with single-dose remimazolam tosilate in elderly male patients undergoing transurethral resection of the prostate with spinal anesthesia: a prospective, single-arm, single-centre clinical trial. BMC Anesthesiol. 2022;22(1):247. https://doi.org/10.1186/s12871-022-01788-1.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Vellinga R, Koomen JV, Eleveld DJ, et al. Target-controlled infusion of Remimazolam in healthy volunteers shows some acute tolerance. Anesthesiology. 2024;140(2):207–19. https://doi.org/10.1097/ALN.0000000000004811.

Article  PubMed  CAS  Google Scholar 

Hu Q, Liu X, Wen C, et al. Remimazolam: an updated review of a new sedative and anaesthetic. Drug Des Dev Ther. 2022;16:3957–74. https://doi.org/10.2147/DDDT.S384155.

Article  CAS  Google Scholar 

Pastis NJ, Hill NT, Yarmus LB, et al. Correlation of vital signs and depth of sedation by modified observer’s assessment of alertness and sedation (MOAA/S) scale in bronchoscopy. J Bronchol Interv Pulmonol. 2022;29(1):54–61. https://doi.org/10.1097/LBR.0000000000000784.

Article  Google Scholar 

Saugel B, Sessler DI. Perioperative blood pressure management. Anesthesiology. 2021;134(2):250–61. https://doi.org/10.1097/ALN.0000000000003610.

Article  PubMed  Google Scholar 

Xu Q, Wu J, Shan W, et al. Effects of remimazolam combined with sufentanil on hemodynamics during anesthetic induction in elderly patients with mild hypertension undergoing orthopedic surgery of the lower limbs: a randomized controlled trial. BMC Anesthesiol. 2023;23(1):311. https://doi.org/10.1186/s12871-023-02249-z.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gao S, Wang T, Cao L, et al. Clinical effects of remimazolam alone or in combination with dexmedetomidine in patients receiving bronchoscopy and influences on postoperative cognitive function: a randomized-controlled trial. Int J Clin Pharm. 2023;45(1):137–45. https://doi.org/10.1007/s11096-022-01487-4.

Article  PubMed  CAS  Google Scholar 

Lyu S, Deng Q, Lin W, et al. Randomized controlled trial for anesthesia during gastroscopy: interactions between remimazolam and propofol in combination with sufentanil. Int J Clin Pharm. 2023;45(4):857–63. https://doi.org/10.1007/s11096-023-01568-y.

Article  PubMed  PubMed Central  Google Scholar 

Freyer N, Knöspel F, Damm G, et al. Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system. Drug Des Dev Ther. 2019;13:1033–47. https://doi.org/10.2147/DDDT.S186759.

Article  CAS  Google Scholar 

Wang C, Gao Y, Li J, et al. Safety and effectiveness of the combination of remimazolam tosilate and propofol in gastroscopy: a multicenter, randomized controlled, single-blind clinical trial. Front Pharmacol. 2023;14:1124667. https://doi.org/10.3389/fphar.2023.1124667.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sahinovic MM, Struys M, Absalom AR. Clinical pharmacokinetics and pharmacodynamics of propofol. Clin Pharmacokinet. 2018;57(12):1539–58. https://doi.org/10.1007/s40262-018-0672-3.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhu H, Su Z, Zhou H, et al. Remimazolam dosing for gastroscopy: a randomized noninferiority trial. Anesthesiology. 2024;140(3):409–16. https://doi.org/10.1097/ALN.0000000000004851.

Article  PubMed  CAS  Google Scholar 

Hasegawa G, Hirata N, Yoshikawa Y, et al. Differential effects of remimazolam and propofol on heart rate variability during anesthesia induction. J Anesth. 2022;36(2):239–45. https://doi.org/10.1007/s00540-022-03037-8.

Article  PubMed  Google Scholar 

Gao YQ, Ihmsen H, Hu ZY, et al. Pharmacokinetics of remimazolam after intravenous infusion in anaesthetised children. Br J Anaesth. 2023;131(5):914–20. https://doi.org/10.1016/j.bja.2023.08.019.

Article  PubMed  CAS  Google Scholar 

Luo W, Sun M, Wan J, et al. Efficacy and safety of remimazolam tosilate versus propofol in patients undergoing day surgery: a prospective randomized controlled trial. BMC Anesthesiol. 2023;23(1):182. https://doi.org/10.1186/s12871-023-02092-2.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wang L, Wang Y, Ma L, et al. Cardiopulmonary adverse events of remimazolam versus propofol during cervical conization: a randomized controlled trial. Drug Des Dev Ther. 2023;17:1233–43. https://doi.org/10.2147/DDDT.S405057.

Article  CAS  Google Scholar 

Zhang L, Yu L, Xu L, et al. Effectiveness of remimazolam besylate combined with alfentanil for fiberoptic bronchoscopy with preserved spontaneous breathing: a prospective, randomized, controlled clinical trial. Eur Rev Med Pharmacol Sci. 2023;27(13):6071–80. https://doi.org/10.26355/eurrev_202307_32961.

PubMed  CAS  Google Scholar 

Guo J, Qian Y, Zhang X, et al. Remimazolam tosilate compared with propofol for gastrointestinal endoscopy in elderly patients: a prospective, randomized and controlled study. BMC Anesthesiol. 2022;22(1):180. https://doi.org/10.1186/s12871-022-01713-6.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wei A, Ma S, Dou Y, et al. The safety and efficacy of remimazolam tosylate combined with propofol in upper gastrointestinal endoscopy: a multicenter, randomized clinical trial. PLoS ONE. 2023;18(8):e0282930. https://doi.org/10.1371/journal.pone.0282930.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kilpatrick GJ. Remimazolam: non-clinical and clinical profile of a new sedative/anesthetic agent. Front Pharmacol. 2021;12:690875. https://doi.org/10.3389/fphar.2021.690875.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang Y, Dai G, Xu H, et al. Safety and efficacy of remimazolam compared with propofol in induction of general anesthesia: a reply. Minerva Anestesiol. 2022;88(3):194–5. https://doi.org/10.23736/S0375-9393.21.16169-3.

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