Smolen JS, Aletaha D, Mcinnes IB (2016) Rheumatoid arthritis [J]. Lancet (London, England) 388(10055):2023–2038

Article  CAS  PubMed  Google Scholar 

Smolen JS, Aletaha D, Barton A et al (2018) Rheumatoid arthritis [J]. Nature Rev Dis Primers 4:18001

Article  Google Scholar 

Szekanecz Z, Koch AE, Tak PP (2011) Chemokine and chemokine receptor blockade in arthritis, a prototype of immune-mediated inflammatory diseases [J]. Neth J Med 69(9):356–366

CAS  PubMed  Google Scholar 

Deane KD, Demoruelle MK, Kelmenson LB et al (2017) Genetic and environmental risk factors for rheumatoid arthritis [J]. Best Pract Res Clin Rheumatol 31(1):3–18

Article  PubMed  PubMed Central  Google Scholar 

Huang J, Fu X, Chen X et al (2021) Promising therapeutic targets for treatment of rheumatoid arthritis [J]. Front Immunol 12:686155

Article  CAS  PubMed  PubMed Central  Google Scholar 

Littlejohn EA, Monrad SU (2018) Early diagnosis and treatment of rheumatoid arthritis [J]. Prim Care 45(2):237–255

Article  PubMed  Google Scholar 

Sacks JJ, Luo YH, Helmick CG (2010) Prevalence of specific types of arthritis and other rheumatic conditions in the ambulatory health care system in the United States, 2001–2005 [J]. Arthritis Care Res 62(4):460–464

Article  Google Scholar 

Ngo ST, Steyn FJ, Mccombe PA (2014) Gender differences in autoimmune disease [J]. Front Neuroendocrinol 35(3):347–369

Article  CAS  PubMed  Google Scholar 

Schett G (2017) Autoimmunity as a trigger for structural bone damage in rheumatoid arthritis [J]. Mod Rheumatol 27(2):193–197

Article  CAS  PubMed  Google Scholar 

Buch MH, Eyre S, Mcgonagle D (2021) Persistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis [J]. Nat Rev Rheumatol 17(1):17–33

Article  PubMed  Google Scholar 

Behl T, Upadhyay T, Singh S, et al (2021) Polyphenols targeting MAPK mediated oxidative stress and inflammation in rheumatoid arthritis. Molecules 26(21):6570

Carmona-Rivera C, Carlucci PM, Goel RR et al (2020) Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis. JCI Insight 5(13):e139388

Smolen JS, Landewé R, Bijlsma J et al (2017) EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update [J]. Ann Rheum Dis 76(6):960–977

Article  PubMed  Google Scholar 

Tanaka S (2018) Emerging anti-osteoclast therapy for rheumatoid arthritis [J]. J Orthopaedic Sci: Off J Japanese Orthopaedic Assoc 23(5):717–721

Article  Google Scholar 

Crispino N, Ciccia F (2021) JAK/STAT pathway and nociceptive cytokine signalling in rheumatoid arthritis and psoriatic arthritis [J]. Clin Exp Rheumatol 39(3):668–675

Article  PubMed  Google Scholar 

Ilchovska DD, Barrow DM (2021) An overview of the NF-kB mechanism of pathophysiology in rheumatoid arthritis, investigation of the NF-kB ligand RANKL and related nutritional interventions [J]. Autoimmun Rev 20(2):102741

Article  CAS  PubMed  Google Scholar 

Ba X, Huang Y, Shen P et al (2021) WTD attenuating rheumatoid arthritis via suppressing angiogenesis and modulating the PI3K/AKT/mTOR/HIF-1α pathway [J]. Front Pharmacol 12:696802

Article  PubMed  PubMed Central  Google Scholar 

Ibrahim SSA, Huttunen KM (2021) Orchestrated modulation of rheumatoid arthritis via crosstalking intracellular signaling pathways [J]. Inflammopharmacology 29(4):965–974

Article  CAS  PubMed  Google Scholar 

Novikov FN, Panova MV, Titov IY et al (2021) Inhibition of SYK and cSrc kinases can protect bone and cartilage in preclinical models of osteoarthritis and rheumatoid arthritis [J]. Sci Rep 11(1):23120

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, Cheng W, Li J et al (2021) Notch-1 and Notch-3 mediate hypoxia-induced activation of synovial fibroblasts in rheumatoid arthritis [J]. Arthritis Rheumatol (Hoboken, NJ) 73(10):1810–9

Article  CAS  Google Scholar 

Ren W, Rubini P, Tang Y et al (2021) Inherent P2X7 receptors regulate macrophage functions during inflammatory diseases. International J Mol Sci 23(1):232

Sehnert B, Burkhardt H, DüBEL S et al (2020) Cell-type targeted NF-kappaB inhibition for the treatment of inflammatory diseases. Cells 9(7):1627

Sen R, Baltimore D (1986) Multiple nuclear factors interact with the immunoglobulin enhancer sequences [J]. Cell 46(5):705–716

Article  CAS  PubMed  Google Scholar 

Pires BRB, Silva R, Ferreira GM et al (2018) NF-kappaB: two sides of the same coin. Genes (Basel) 9(1):24

Hayden MS, Ghosh S (2008) Shared principles in NF-kappaB signaling [J]. Cell 132(3):344–362

Article  CAS  PubMed  Google Scholar 

Zhao Y, Sun X, Lin J et al (2021) Panaxynol induces fibroblast-like synovial cell apoptosis, inhibits proliferation and invasion through TLR4/NF-κB pathway to alleviate rheumatoid arthritis [J]. Int Immunopharmacol 101(Pt A):108321

Article  CAS  PubMed  Google Scholar 

Van Loo G, Beyaert R (2011) Negative regulation of NF-κB and its involvement in rheumatoid arthritis [J]. Arthritis Res Ther 13(3):221

Article  PubMed  PubMed Central  Google Scholar 

Li J, Tang RS, Shi Z et al (2020) Nuclear factor-κB in rheumatoid arthritis [J]. Int J Rheum Dis 23(12):1627–1635

Article  CAS  PubMed  Google Scholar 

Duan W, Li H (2018) Combination of NF-kB targeted siRNA and methotrexate in a hybrid nanocarrier towards the effective treatment in rheumatoid arthritis [J]. J Nanobiotechnol 16(1):58

Article  Google Scholar 

Chen Y, Wang Y, Liu M et al (2020) Diosmetin exhibits anti-proliferative and anti-inflammatory effects on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes through regulating the Akt and NF-κB signaling pathways [J]. Phytotherapy Res: PTR 34(6):1310–1319

Article  CAS  Google Scholar 

Kondo N, Kuroda T, Kobayashi D (2021) Cytokine networks in the pathogenesis of rheumatoid arthritis [J]. Int J Mol Sci 22(20)

Keewan E, Naser SA (2020) The role of notch signaling in macrophages during inflammation and infection: implication in rheumatoid arthritis?. Cells 9(1):111

Ambili R, Janam P (2017) A critique on nuclear factor-kappa B and signal transducer and activator of transcription 3: the key transcription factors in periodontal pathogenesis [J]. J Indian Society Periodontol 21(5):350–356

Article  Google Scholar 

Lowell CA (2011) Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk. Cold Spring Harbor Perspectives in Biol 3(3):a002352

Jimi E, Fei H, Nakatomi C (2019) NF-κB signaling regulates physiological and pathological chondrogenesis. Int J Mol Sci 20(24):6275

Vrábel D, Pour L, Ševčíková S (2019) The impact of NF-κB signaling on pathogenesis and current treatment strategies in multiple myeloma. Blood Rev 34:56–66

Jimi E, Ghosh S (2005) Role of nuclear factor-kappaB in the immune system and bone [J]. Immunol Rev 208:80–7

Article  CAS  PubMed  Google Scholar 

Oeckinghaus A, Ghosh S (2009) The NF-kappaB family of transcription factors and its regulation [J]. Cold Spring Harb Perspect Biol 1(4):a000034

Article  PubMed  PubMed Central  Google Scholar 

Yu L, Li L, Medeiros LJ et al (2017) NF-κB signaling pathway and its potential as a target for therapy in lymphoid neoplasms [J]. Blood Rev 31(2):77–92

Article  CAS  PubMed  Google Scholar 

Perkins ND (2007) Integrating cell-signalling pathways with NF-kappaB and IKK function [J]. Nat Rev Mol Cell Biol 8(1):49–62

Article  CAS  PubMed  Google Scholar 

Smale ST (2012) Dimer-specific regulatory mechanisms within the NF-κB family of transcription factors [J]. Immunol Rev 246(1):193–204

Article  PubMed  Google Scholar 

Hayden MS, Ghosh S (2004) Signaling to NF-kappaB [J]. Genes Dev 18(18):2195–2224

Article  CAS  PubMed  Google Scholar 

Wang Y, Wang L, Wen X et al (2019) NF-κB signaling in skin aging [J]. Mechanisms Ageing Dev 184:111160

Article