Naringenin Protected Against Blood Brain Barrier Breakdown after Ischemic Stroke through GSK-3β/ β-Catenin Pathway

Xu X, Chen M, Zhu D (2023) Reperfusion and cytoprotective agents are a mutually beneficial pair in ischaemic stroke therapy: an overview of pathophysiology, pharmacological targets and candidate drugs focusing on excitotoxicity and free radical. Stroke Vasc Neurol 9:351–359

Zhang M, Liu Q, Meng H, Duan H, Liu X, Wu J, Gao F, Wang S, Tan R, Yuan J (2024) Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets. Signal Transduct Target Ther 9:12

Article  PubMed  PubMed Central  Google Scholar 

Abdelsalam SA, Renu K, Zahra HA, Abdallah BM, Ali EM, Veeraraghavan VP, Sivalingam K, Ronsard L, Ammar RB, Vidya DS et al (2023) Polyphenols Mediate Neuroprotection in Cerebral Ischemic Stroke-An Update. Nutrients 15

Wu S, Guo T, Qi W, Li Y, Gu J, Liu C, Sha Y, Yang B, Hu S, Zong X (2021) Curcumin ameliorates ischemic stroke injury in rats by protecting the integrity of the blood-brain barrier. Exp Ther Med 22:783

Article  PubMed  PubMed Central  Google Scholar 

Liu B, Tan Y, Wang D, Liu M (2016) Puerarin for ischaemic stroke. Cochrane Database Syst Rev 2:D4955

Google Scholar 

Goyal A, Verma A, Dubey N, Raghav J, Agrawal A (2022) Naringenin: a prospective therapeutic agent for Alzheimer’s and Parkinson’s disease. J Food Biochem 46:e14415

Article  PubMed  Google Scholar 

Abdullahi W, Tripathi D, Ronaldson PT (2018) Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection. Am J Physiol Cell Physiol 315:C343–C356

Article  PubMed  PubMed Central  Google Scholar 

Strbian D, Durukan A, Pitkonen M, Marinkovic I, Tatlisumak E, Pedrono E, Abo-Ramadan U, Tatlisumak T (2008) The blood-brain barrier is continuously open for several weeks following transient focal cerebral ischemia. Neuroscience 153:175–181

Article  PubMed  Google Scholar 

Lin CY, Chang C, Cheung WM, Lin MH, Chen JJ, Hsu CY, Chen JH, Lin TN (2008) Dynamic changes in vascular permeability, cerebral blood volume, vascular density, and size after transient focal cerebral ischemia in rats: evaluation with contrast-enhanced magnetic resonance imaging. J Cereb Blood Flow Metab 28:1491–1501

Article  PubMed  Google Scholar 

Zhou J, Sun F, Zhang W, Feng Z, Yang Y, Mei Z (2024) Novel insight into the therapeutical potential of flavonoids from traditional Chinese medicine against cerebral ischemia/reperfusion injury. Front Pharmacol 15:1352760

Article  PubMed  PubMed Central  Google Scholar 

Liebner S, Dijkhuizen RM, Reiss Y, Plate KH, Agalliu D, Constantin G (2018) Functional morphology of the blood-brain barrier in health and disease. Acta Neuropathol 135:311–336

Article  PubMed  PubMed Central  Google Scholar 

Clevers H, Nusse R (2012) Wnt/beta-catenin signaling and disease. Cell 149:1192–1205

Article  PubMed  Google Scholar 

Yu L, Wang J, Xia Y, Hou W, Yao X, Guo Y, Wang J, Wei H, Wang S (2023) Adiponectin promotes Neurogenesis after transient cerebral ischemia through STAT3 mediated BDNF upregulation in astrocytes. Neurochem Res 48:641–657

Article  PubMed  Google Scholar 

Ashwal S, Tone B, Tian HR, Cole DJ, Pearce WJ (1998) Core and penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion. Stroke 29:1037–1046

Article  PubMed  Google Scholar 

Boulay AC, Saubamea B, Decleves X, Cohen-Salmon M (2015) Purification of mouse brain vessels. J Vis Exp 105

Crouch EE, Doetsch F (2018) FACS isolation of endothelial cells and pericytes from mouse brain microregions. Nat Protoc 13:738–751

Article  PubMed  Google Scholar 

Tran KA, Zhang X, Predescu D, Huang X, Machado RF, Gothert JR, Malik AB, Valyi-Nagy T, Zhao YY (2016) Endothelial beta-catenin signaling is required for maintaining adult blood-brain Barrier Integrity and Central Nervous System Homeostasis. Circulation 133:177–186

Article  PubMed  Google Scholar 

Mo Z, Zeng Z, Liu Y, Zeng L, Fang J, Ma Y (2022) Activation of Wnt/Beta-Catenin signaling pathway as a promising therapeutic candidate for cerebral Ischemia/Reperfusion Injury. Front Pharmacol 13:914537

Article  PubMed  PubMed Central  Google Scholar 

Motallebi M, Bhia M, Rajani HF, Bhia I, Tabarraei H, Mohammadkhani N, Pereira-Silva M, Kasaii MS, Nouri-Majd S, Mueller AL et al (2022) Naringenin: a potential flavonoid phytochemical for cancer therapy. Life Sci 305:120752

Article  PubMed  Google Scholar 

Zhang X, Zhang XF, Wang L, Guo DY, Zhang JM, Chen YG, Wang ZC, Pei LS, Chen JX, Shi YJ, Zou JB (2020) Analysis of clinical efficacy of traditional Chinese Medicine in Recovery Stage of Stroke: a systematic review and Meta-analysis. Cardiovasc Ther 2020. 7172052

Fan G, Liu M, Liu J, Huang Y, Mu W (2024) Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms. Phytother Res 38:411–453

Article  PubMed  Google Scholar 

Wang S, Ma F, Huang L, Zhang Y, Peng Y, Xing C, Feng Y, Wang X, Peng Y (2018) Dl-3-n-Butylphthalide (NBP): a Promising Therapeutic Agent for ischemic stroke. CNS Neurol Disord Drug Targets 17:338–347

Article  PubMed  Google Scholar 

Zheng T, Jiang T, Huang Z, Ma H, Wang M (2023) Role of traditional Chinese medicine monomers in cerebral ischemia/reperfusion injury:a review of the mechanism. Front Pharmacol 14:1220862

Article  PubMed  PubMed Central  Google Scholar 

Wang K, Chen Z, Huang J, Huang L, Luo N, Liang X, Liang M, Xie W (2017) Naringenin prevents ischaemic stroke damage via anti-apoptotic and anti-oxidant effects. Clin Exp Pharmacol Physiol 44:862–871

Article  PubMed  Google Scholar 

Bhia M, Motallebi M, Abadi B, Zarepour A, Pereira-Silva M, Saremnejad F, Santos AC, Zarrabi A, Melero A, Jafari SM, Shakibaei M (2021) Naringenin Nano-Delivery Systems and Their Therapeutic Applications. Pharmaceutics 13

Wei H, Zhen L, Wang S, Yang L, Zhang S, Zhang Y, Jia P, Wang T, Wang K, Zhang Y et al (2023) Glyceryl triacetate promotes blood-brain barrier recovery after ischemic stroke through lipogenesis-mediated IL-33 in mice. J Neuroinflammation 20:264

Article  PubMed  PubMed Central  Google Scholar 

Liu B, Li Y, Han Y, Wang S, Yang H, Zhao Y, Li P, Wang Y (2021) Notoginsenoside R1 intervenes degradation and redistribution of tight junctions to ameliorate blood-brain barrier permeability by Caveolin-1/MMP2/9 pathway after acute ischemic stroke. Phytomedicine 90:153660

Article  PubMed  Google Scholar 

Liao Y, Hu J, Guo C, Wen A, Wen L, Hou Q, Weng Y, Wang J, Ding Y, Yang J (2024) Acteoside alleviates blood-brain barrier damage induced by ischemic stroke through inhibiting microglia HMGB1/TLR4/NLRP3 signaling. Biochem Pharmacol 220:115968

Article  PubMed  Google Scholar 

Zhao Y, Gan L, Ren L, Lin Y, Ma C, Lin X (2022) Factors influencing the blood-brain barrier permeability. Brain Res 1788:147937

Article  PubMed  Google Scholar 

Gu X, Dong M, Xia S, Li H, Bao X, Cao X, Xu Y (2024) Gamma-glutamylcysteine ameliorates blood-brain barrier permeability and neutrophil extracellular traps formation after ischemic stroke by modulating Wnt/beta-catenin signalling in mice. Eur J Pharmacol 969:176409

Article  PubMed  Google Scholar 

Kang Q, Gong J, Wang M, Wang Q, Chen F, Cheng KW (2019) 6-C-(E-Phenylethenyl)Naringenin attenuates the stemness of Hepatocellular Carcinoma Cells by suppressing Wnt/beta-Catenin signaling. J Agric Food Chem 67:13939–13947

Article  PubMed  Google Scholar 

Song S, Huang H, Guan X, Fiesler V, Bhuiyan M, Liu R, Jalali S, Hasan MN, Tai AK, Chattopadhyay A et al (2021) Activation of endothelial Wnt/beta-catenin signaling by protective astrocytes repairs BBB damage in ischemic stroke. Prog Neurobiol 199:101963

Article  PubMed  Google Scholar 

Huang YC, Yang CH, Chiou YL (2011) Citrus flavanone naringenin enhances melanogenesis through the activation of Wnt/beta-catenin signalling in mouse melanoma cells. Phytomedicine 18:1244–1249

Article  PubMed  Google Scholar 

Dayarathne LA, Ranaweera SS, Natraj P, Rajan P, Lee YJ, Han CH (2021) The effects of naringenin and naringin on the glucose uptake and AMPK phosphorylation in high glucose treated HepG2 cells. J Vet Sci 22:e92

Article  PubMed  PubMed Central  Google Scholar 

Wei H, Yao X, Yang L, Wang S, Guo F, Zhou H, Marsicano G, Wang Q, Xiong L (2014) Glycogen synthase kinase-3beta is involved in electroacupuncture pretreatment via the cannabinoid CB1 receptor in ischemic stroke. Mol Neurobiol 49:326–336

Article  PubMed  Google Scholar 

Kretzschmar G, Vollmer G, Schwab P, Tischer S, Metz P, Zierau O (2007) Effects of the chemically synthesized flavanone 7-(O-prenyl)naringenin-4’-acetate on the estrogen signaling pathway in vivo and in vitro. J Steroid Biochem Mol Biol 107:114–119

Article  PubMed  Google Scholar 

Liu HW, Gong LN, Lai K, Yu XF, Liu ZQ, Li MX, Yin XL, Liang M, Shi HS, Jiang LH et al (2023) Bilirubin gates the TRPM2 channel as a direct agonist to exacerbate ischemic brain damage. Neuron 111:1609–1625

Article  PubMed  PubMed Central 

留言 (0)

沒有登入
gif