Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaye AD, Okeagu CN, Pham AD, Silva RA, Hurley JJ, Arron BL, et al. Economic impact of COVID-19 pandemic on healthcare facilities and systems: international perspectives. Best Pract Res Clin Anaesthesiol. 2021;35(3):293–306.

Article  PubMed  Google Scholar 

Vigano C, Mulinacci G, Palermo A, Barisani D, Pirola L, Fichera M, et al. Impact of COVID-19 on inflammatory bowel disease practice and perspectives for the future. World J Gastroenterol. 2021;27(33):5520–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cushing K, Higgins PDR. Management of Crohn Disease: A Review. JAMA. 2021;325(1):69–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gisbert JP, Marin AC, Chaparro M. The risk of relapse after Anti-TNF discontinuation in inflammatory bowel disease: systematic review and meta-analysis. Am J Gastroenterol. 2016;111(5):632–47.

Article  CAS  PubMed  Google Scholar 

Kirchgesner J, Lemaitre M, Carrat F, Zureik M, Carbonnel F, Dray-Spira R. Risk of serious and opportunistic infections associated with treatment of inflammatory bowel diseases. Gastroenterology. 2018;155(2):337–46.

Article  PubMed  Google Scholar 

Ungaro RC, Brenner EJ, Gearry RB, Kaplan GG, Kissous-Hunt M, Lewis JD, et al. Effect of IBD medications on COVID-19 outcomes: results from an international registry. Gut. 2021;70(4):725–32.

Article  CAS  PubMed  Google Scholar 

Rubin DT, Feuerstein JD, Wang AY, Cohen RD. AGA Clinical practice update on management of inflammatory bowel disease during the COVID-19 pandemic: expert commentary. Gastroenterology. 2020;159(1):350–7.

Article  CAS  PubMed  Google Scholar 

Feldmann M, Maini RN, Woody JN, Holgate ST, Winter G, Rowland M, et al. Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed. Lancet. 2020;395(10234):1407–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Michot JM, Albiges L, Chaput N, Saada V, Pommeret F, Griscelli F, et al. Tocilizumab, an anti-IL-6 receptor antibody, to treat COVID-19-related respiratory failure: a case report. Ann Oncol. 2020;31(7):961–4.

Article  PubMed  Google Scholar 

Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020;395(10224):565–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan. China Lancet. 2020;395(10223):497–506.

Article  CAS  PubMed  Google Scholar 

Zou L, Ruan F, Huang M, Liang L, Huang H, Hong Z, et al. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med. 2020;382(12):1177–9.

Article  PubMed  PubMed Central  Google Scholar 

Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese center for disease control and prevention. JAMA. 2020;323(13):1239–42.

Article  CAS  PubMed  Google Scholar 

Yadlapati S, Lo KB, DeJoy R, Gul F, Peterson E, Bhargav R, et al. Prevailing patterns of liver enzymes in patients with COVID-19 infection and association with clinical outcomes. Ann Gastroenterol. 2021;34(2):224–8.

PubMed  PubMed Central  Google Scholar 

Hoffmann M, Kleine-Weber H, Schroeder S, Kruger N, Herrler T, Erichsen S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patel KP, Patel PA, Vunnam RR, Hewlett AT, Jain R, Jing R, et al. Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19. J Clin Virol. 2020;128: 104386.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin W, Fan J, Hu LF, Zhang Y, Ooi JD, Meng T, et al. Single-cell analysis of angiotensin-converting enzyme II expression in human kidneys and bladders reveals a potential route of 2019 novel coronavirus infection. Chin Med J (Engl). 2021;134(8):935–43.

Article  CAS  PubMed  Google Scholar 

Pan L, Mu M, Yang P, Sun Y, Wang R, Yan J, et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional. Multicenter Study Am J Gastroenterol. 2020;115(5):766–73.

Article  PubMed  Google Scholar 

Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci. 2020;12(1):8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng YY, Ma YT, Zhang JY, Xie X. COVID-19 and the cardiovascular system. Nat Rev Cardiol. 2020;17(5):259–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Merad M, Martin JC. Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages. Nat Rev Immunol. 2020;20(6):355–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thevarajan I, Nguyen THO, Koutsakos M, Druce J, Caly L, van de Sandt CE, et al. Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19. Nat Med. 2020;26(4):453–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng M, Gao Y, Wang G, Song G, Liu S, Sun D, et al. Functional exhaustion of antiviral lymphocytes in COVID-19 patients. Cell Mol Immunol. 2020;17(5):533–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tan L, Wang Q, Zhang D, Ding J, Huang Q, Tang YQ, et al. Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study. Signal Transduct Target Ther. 2020;5(1):33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ying T, Li W, Dimitrov DS. Discovery of T-cell infection and apoptosis by middle east respiratory syndrome coronavirus. J Infect Dis. 2016;213(6):877–9.

Article  PubMed  Google Scholar 

Andre S, Picard M, Cezar R, Roux-Dalvai F, Alleaume-Butaux A, Soundaramourty C, et al. T cell apoptosis characterizes severe Covid-19 disease. Cell Death Differ. 2022;29:1486–99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ross SH, Cantrell DA. Signaling and function of interleukin-2 in T lymphocytes. Annu Rev Immunol. 2018;36:411–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mahmoodpoor A, Hosseini M, Soltani-Zangbar S, Sanaie S, Aghebati-Maleki L, Saghaleini SH, et al. Reduction and exhausted features of T lymphocytes under serological changes, and prognostic factors in COVID-19 progression. Mol Immunol. 2021;138:121–7.

Article  CAS  PubMed