López-Otín C et al (2013) The hallmarks of aging. Cell 153:1194–1217
Article PubMed PubMed Central Google Scholar
Sala Frigerio C et al (2019) The major risk factors for Alzheimer’s Disease: age, sex, and genes modulate the Microglia response to Aβ plaques. Cell Rep 27:1293–1306e1296
Article CAS PubMed Google Scholar
Mattson MP et al (2018) Hallmarks of Brain Aging: adaptive and pathological modification by Metabolic States. Cell Metabol 27:1176–1199
Liguori I et al (2018) Oxidative stress, aging, and diseases. Clin Interv Aging 13:757
Article CAS PubMed PubMed Central Google Scholar
Poddar J et al (2019) Biochemical deficits and cognitive decline in brain aging: intervention by dietary supplements. J Chem Neuroanat 95:70–80
Article CAS PubMed Google Scholar
Adams SL et al (2018) Immunohistochemical Analysis of Activin Receptor-like Kinase 1 (ACVRL1/ALK1) expression in the rat and human Hippocampus: decline in CA3 during progression of Alzheimer’s Disease. J Alzheimer’s Disease: JAD 63:1433–1443
Article CAS PubMed Google Scholar
Fellini L et al (2006) Adult but not aged C57BL/6 male mice are capable of using geometry for orientation. Learn Memory (Cold Spring Harbor N Y) 13:473–481
Shoji H et al (2016) Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age. Mol Brain 9:11
Article PubMed PubMed Central Google Scholar
Kluever V et al (2021) Principles of brain aging: Status and challenges of modeling human molecular changes in mice. Ageing Res Rev 72:101465
Article CAS PubMed Google Scholar
Neha et al (2014) Animal models of dementia and cognitive dysfunction. Life Sci 109:73–86
Article CAS PubMed Google Scholar
Silva FDD et al (2024) Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: a multi-target compound with potential therapeutic applications. Blood Cells Mol Dis 106:102827
Article CAS PubMed Google Scholar
Fonseca-Fonseca LA et al (2024) Correlational assessment of the effects of JM-20 in a rat model of parkinsonism. Behav Brain Res 5:476:115269. https://doi.org/10.1016/j.bbr.2024.115269
Santos CC et al (2022) JM-20, a benzodiazepine-dihydropyridine hybrid molecule, inhibits the formation of alpha-synuclein-aggregated species. Neurotox Res 40:2135–2147
Article CAS PubMed Google Scholar
Fonseca-Fonseca LA et al (2021) JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson’s disease: mitochondrial protection and antioxidant properties. Neurotoxicology 82:89–98
Article CAS PubMed Google Scholar
Fonseca-Fonseca LA et al (2019) JM-20, a novel hybrid molecule, protects against rotenone-induced neurotoxicity in experimental model of Parkinson’s disease. Neurosci Lett 690:29–35
Article CAS PubMed Google Scholar
Nunez-Figueredo Y et al (2018) Multi-targeting effects of a new synthetic molecule (JM-20) in experimental models of cerebral ischemia. Pharmacol Rep 70:699–704
Article CAS PubMed Google Scholar
Wong-Guerra M et al (2019) JM-20 protects memory acquisition and consolidation on scopolamine model of cognitive impairment. Neurol Res 41:385–398
Article CAS PubMed Google Scholar
Ramirez-Sanchez J et al (2015) Neuroprotection by JM-20 against oxygen-glucose deprivation in rat hippocampal slices: involvement of the Akt/GSK-3beta pathway. Neurochem Int 90:215–223
Article CAS PubMed Google Scholar
Nunez-Figueredo Y et al (2014) Antioxidant effects of JM-20 on rat brain mitochondria and synaptosomes: mitoprotection against ca(2)(+)-induced mitochondrial impairment. Brain Res Bull 109:68–76
Article CAS PubMed Google Scholar
Nunez-Figueredo Y et al (2014) A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo. Neuropharmacology 85:517–527
Article CAS PubMed Google Scholar
Wong-Guerra M et al (2021) JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats. Neurotoxicology 87:70–85
Article CAS PubMed Google Scholar
D’Avila, da Silva F et al (2020) Molecular docking and in vitro evaluation of a new hybrid molecule (JM-20) on cholinesterase activity from different sources. Biochimie 168:297–306
Furtado ABV et al (2021) JM-20 treatment after mild traumatic brain Injury reduces glial cell pro-inflammatory signaling and behavioral and cognitive deficits by increasing neurotrophin expression. Mol Neurobiol 58:4615–4627
Article CAS PubMed Google Scholar
Garrido-Suarez BB et al (2024) A multi-target ligand (JM-20) prevents morphine-induced hyperalgesia in naive and neuropathic rats. Eur J Pharmacol 983:176992
Article CAS PubMed Google Scholar
Garrido-Suarez BB et al (2020) Anti-hypernociceptive and anti-inflammatory effects of JM-20: a novel hybrid neuroprotective compound. Brain Res Bull 165:185–197
Article CAS PubMed Google Scholar
Dos Santos MM et al (2024) JM-20 potently prevents the onset of caffeine-induced anxiogenic phenotypes in zebrafish (Danio rerio). Comp Biochem Physiol C Toxicol Pharmacol 277:109843
Article CAS PubMed Google Scholar
da Silva AF et al (2022) JM-20 affects GABA neurotransmission in Caenorhabditis elegans. Neurotoxicology 93:37–44
Figueredo YN et al (2013) Characterization of the anxiolytic and sedative profile of JM-20: a novel benzodiazepine–dihydropyridine hybrid molecule. Neurol Res 35:804–812
Article CAS PubMed Google Scholar
Hidaka N et al (2011) Inhibitory effects of valproate on impairment of Y-maze alternation behavior induced by repeated electroconvulsive seizures and c-Fos protein levels in rat brains. Acta Med Okayama 65:269–277
Tucci P et al (2014) Memantine prevents memory consolidation failure induced by soluble beta amyloid in rats. Front Behav Neurosci 8:332
Article PubMed PubMed Central Google Scholar
Walsh RN et al (1975) Mechanisms mediating the production of environmentally induced brain changes. Psychol Bull 82:986
Article CAS PubMed Google Scholar
Wong-Guerra M et al (2017) Mitochondrial involvement in memory impairment induced by scopolamine in rats. Neurol Res 39:649–659
Article CAS PubMed Google Scholar
Lowry OH et al (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275
Article CAS PubMed Google Scholar
Du S et al (2018) Mangiferin: an effective therapeutic agent against several disorders (review). Mol Med Rep 18:4775–4786
留言 (0)