Zhang M, Shi Y, Zhou B, Huang Z, Zhao Z, Li C, et al. Prevalence, awareness, treatment, and control of hypertension in China, 2004-18: findings from six rounds of a national survey. BMJ. 2023;380:e071952.
Article PubMed PubMed Central Google Scholar
Oliveros E, Patel H, Kyung S, Fugar S, Goldberg A, Madan N, et al. Hypertension in older adults: Assessment, management, and challenges. Clin Cardiol. 2020;43:99–107.
Wang Z, Wang S, Lin H, Wang C, Gao D. Prevalence of hypertension and related risk factors in older Chinese population: a meta-analysis. Front Public Health. 2024;12:1320295.
Article PubMed PubMed Central Google Scholar
Franklin SS, Larson MG, Khan SA, Wong ND, Leip EP, Kannel WB, et al. Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study. Circulation. 2001;103:1245–9.
Article PubMed CAS Google Scholar
Qiu W, Cai A, Nie Z, Wang J, Ou Y, Feng Y. Cardiometabolic factors and population risks of cardiovascular disease in community-dwelling adults with varied blood pressure statuses. Diab Obes Metab. 2024;26:3261–71.
Li K, Gao L, Jiang Y, Jia J, Li J, Fan F, et al. Association of cardiovascular events with central systolic blood pressure: A systemic review and meta-analysis. J Clin Hypertens. 2024;26:747–56.
Bullo M, Papandreou C, Garcia-Gavilan J, Ruiz-Canela M, Li J, Guasch-Ferre M, et al. Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure. Metab Clin Exp. 2021;125:154915.
Article PubMed CAS Google Scholar
Santos JL, Ruiz-Canela M, Razquin C, Clish CB, Guasch-Ferre M, Babio N, et al. Circulating citric acid cycle metabolites and risk of cardiovascular disease in the PREDIMED study. Nutr Metab Cardiovasc Dis NMCD. 2023;33:835–43.
Article PubMed CAS Google Scholar
Haas J, Frese KS, Sedaghat-Hamedani F, Kayvanpour E, Tappu R, Nietsch R, et al. Energy Metabolites as Biomarkers in Ischemic and Dilated Cardiomyopathy. Int J Mol Sci. 2021;22:1999.
Doenst T, Nguyen TD, Abel ED. Cardiac metabolism in heart failure: implications beyond ATP production. Circulation Res. 2013;113:709–24.
Article PubMed CAS Google Scholar
Nelson SE, Ament Z, Wolcott Z, Gerszten RE, Kimberly WT. Succinate links atrial dysfunction and cardioembolic stroke. Neurology. 2019;92:e802–e10.
Article PubMed PubMed Central CAS Google Scholar
Juraschek SP, Bower JK, Selvin E, Subash Shantha GP, Hoogeveen RC, Ballantyne CM, et al. Plasma lactate and incident hypertension in the atherosclerosis risk in communities study. Am J Hypertens. 2015;28:216–24.
Article PubMed CAS Google Scholar
Crawford SO, Ambrose MS, Hoogeveen RC, Brancati FL, Ballantyne CM, Young JH. Association of lactate with blood pressure before and after rapid weight loss. Am J Hypertens. 2008;21:1337–42.
Article PubMed CAS Google Scholar
Wu W, Jiang S, Zhao Q, Zhang K, Wei X, Zhou T, et al. Associations of environmental exposure to metals with the risk of hypertension in China. Sci Total Environ. 2018;622-623:184–91.
Article PubMed CAS Google Scholar
Hu MJ, He JL, Tong XR, Yang WJ, Zhao HH, Li GA, et al. Associations between essential microelements exposure and the aggressive clinicopathologic characteristics of papillary thyroid cancer. Biometals Int J role Met Ions Biol Biochem Med. 2021;34:909–21.
Merino J, Leong A, Liu CT, Porneala B, Walford GA, von Grotthuss M, et al. Metabolomics insights into early type 2 diabetes pathogenesis and detection in individuals with normal fasting glucose. Diabetologia. 2018;61:1315–24.
Article PubMed PubMed Central CAS Google Scholar
Osuna-Prieto FJ, Martinez-Tellez B, Ortiz-Alvarez L, Di X, Jurado-Fasoli L, Xu H, et al. Elevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adults. Cardiovasc Diabetol. 2021;20:151.
Article PubMed PubMed Central CAS Google Scholar
Muller OJ, Heckmann MB, Ding L, Rapti K, Rangrez AY, Gerken T, et al. Comprehensive plasma and tissue profiling reveals systemic metabolic alterations in cardiac hypertrophy and failure. Cardiovasc Res. 2019;115:1296–305.
Guo Y, Chen SF, Zhang YR, Wang HF, Huang SY, Chen SD, et al. Circulating metabolites associated with incident myocardial infarction and stroke: A prospective cohort study of 90 438 participants. J Neurochem. 2022;162:371–84.
Article PubMed CAS Google Scholar
Calderon-Santiago M, Priego-Capote F, Galache-Osuna JG, Luque de Castro MD. Method based on GC-MS to study the influence of tricarboxylic acid cycle metabolites on cardiovascular risk factors. J Pharm Biomed Anal. 2013;74:178–85.
Article PubMed CAS Google Scholar
Mouton AJ, Li X, Hall ME, Hall JE. Obesity, Hypertension, and Cardiac Dysfunction: Novel Roles of Immunometabolism in Macrophage Activation and Inflammation. Circulation Res. 2020;126:789–806.
Article PubMed CAS Google Scholar
Passacquale G, Di Giosia P, Ferro A. The role of inflammatory biomarkers in developing targeted cardiovascular therapies: lessons from the cardiovascular inflammation reduction trials. Cardiovasc Res. 2016;109:9–23.
Article PubMed CAS Google Scholar
Gao S, Zhao J, Liu X, Liu L, Chen R. Metabolomics reveals serum metabolic signatures in H-type hypertension based on mass spectrometry multi-platform. Eur J Clin Investig. 2023;53:e14063.
Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D. Alpha-Ketoglutarate: Physiological Functions and Applications. Biomolecules Therapeutics. 2016;24:1–8.
Article PubMed PubMed Central CAS Google Scholar
Shi M, He J, Li C, Lu X, He WJ, Cao J, et al. Metabolomics study of blood pressure salt-sensitivity and hypertension. Nutr Metab Cardiovasc Dis. 2022;32:1681–92.
Article PubMed PubMed Central CAS Google Scholar
Wawrzyniak R, Gresner P, Lewicka E, Macioszek S, Furga A, Zieba B, et al. Metabolomics Meets Clinics: A Multivariate Analysis of Plasma and Urine Metabolic Signatures in Pulmonary Arterial Hypertension. J Proteome Res. 2024;23:2795–804.
Article PubMed CAS Google Scholar
An D, Zeng Q, Zhang P, Ma Z, Zhang H, Liu Z, et al. Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice. Redox Biol. 2021;46:102088.
Article PubMed PubMed Central CAS Google Scholar
Gyanwali B, Lim ZX, Soh J, Lim C, Guan SP, Goh J, et al. Alpha-Ketoglutarate dietary supplementation to improve health in humans. Trends Endocrinol Metab TEM. 2022;33:136–46.
Article PubMed CAS Google Scholar
Cheng T, Wang H, Hu Y. The causal effects of genetically determined human blood metabolites on the risk of atrial fibrillation. Front Cardiovasc Med. 2023;10:1211458.
Article PubMed PubMed Central Google Scholar
Sanchez-Gimenez R, Peiro OM, Bonet G, Carrasquer A, Fragkiadakis GA, Bullo M, et al. TCA cycle metabolites associated with adverse outcomes after acute coronary syndrome: mediating effect of renal function. Front Cardiovasc Med. 2023;10:1157325.
Article PubMed PubMed Central CAS Google Scholar
Edosuyi O, Adesuyi A, Choi M, Igbe I, Oyekan A. Malate reduced blood pressure and exerted differential effects on renal hemodynamics; role of the nitric oxide system and renal epithelial sodium channels (E(Na)C). Eur J Pharmacol. 2023;938:175441.
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