Weight loss and metabolic effects of an ALDH1A1-specific inhibitor, FSI-TN42, in a diet induced mouse model of obesity

Apovian CM. Obesity: definition, comorbidities, causes, and burden. Am J Manag Care. 2016;22:s176–85.

PubMed  Google Scholar 

Malnick SD, Knobler H. The medical complications of obesity. QJM. 2006;99:565–79.

Article  CAS  PubMed  Google Scholar 

Perdomo CM, Cohen RV, Sumithran P, Clement K, Fruhbeck G. Contemporary medical, device, and surgical therapies for obesity in adults. Lancet. 2023;401:1116–30.

Article  PubMed  Google Scholar 

Blaner WS. Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders. Pharmacol Ther. 2019;197:153–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Niederreither K, Vermot J, Messaddeq N, Schuhbaur B, Chambon P, Dolle P. Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse. Development. 2001;128:1019–31.

Article  CAS  PubMed  Google Scholar 

Dupe V, Matt N, Garnier JM, Chambon P, Mark M, Ghyselinck NB. A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment. Proc Natl Acad Sci USA. 2003;100:14036–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan X, Molotkov A, Manabe S, Donmoyer CM, Deltour L, Foglio MH, et al. Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina. Mol Cell Biol. 2003;23:4637–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ziouzenkova O, Orasanu G, Sharlach M, Akiyama TE, Berger JP, Viereck J, et al. Retinaldehyde represses adipogenesis and diet-induced obesity. Nature Med. 2007;13:695–702.

Article  CAS  PubMed  Google Scholar 

Haenisch M, Treuting PM, Brabb T, Goldstein AS, Berkseth K, Amory JK, et al. Pharmacological inhibition of ALDH1A enzymes suppresses weight gain in a mouse model of diet-induced obesity. Obes Res Clin Pract. 2017;12:93–101.

Haenisch M, Nguyen T, Fihn CA, Goldstein AS, Amory JK, Treuting P, et al. Investigation of an ALDH1A1-specific inhibitor for suppression of weight gain in a diet-induced mouse model of obesity. Int J Obes. 2021;45:1542–52.

Article  CAS  Google Scholar 

Paik J, Fierce Y, Drivdahl R, Treuting PM, Seamons A, Brabb T, et al. Effects of murine norovirus infection on a mouse model of diet-induced obesity and insulin resistance. Comparat Med. 2010;60:189–95.

CAS  Google Scholar 

Paik J, Haenisch M, Muller CH, Goldstein AS, Arnold S, Isoherranen N, et al. Inhibition of retinoic acid biosynthesis by the bisdichloroacetyldiamine WIN 18,446 markedly suppresses spermatogenesis and alters retinoid metabolism in mice. J Biol Chem. 2014;289:15104–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Su B, Bettcher LF, Hsieh WY, Hornburg D, Pearson MJ, Blomberg N, et al. A DMS shotgun lipidomics workflow application to facilitate high-throughput, comprehensive lipidomics. J Am Soc Mass Spectrom. 2021;32:2655–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cudalbu C, McLin VA, Lei H, Duarte JM, Rougemont AL, Oldani G, et al. The C57BL/6J mouse exhibits sporadic congenital portosystemic shunts. PLoS ONE. 2013;8:e69782.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Team RC. R: A Language and Environment for Statistical Computing. In: Computing RFfS, editor. Vienna, Austria 2024.

Dill-McFarland KA, Mitchell K, Batchu S, Segnitz RM, Benson B, Janczyk T, et al. Kimma: flexible linear mixed effects modeling with kinship covariance for RNA-seq data. Bioinformatics. 2023;39:btad279.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wood SN. Fast stable restricted maximum likelihood and marginal likelihood estimation of semiparametric generalized linear models. J Roy Stat Soc B. 2011;73:3–36.

Article  Google Scholar 

Bates D, Mächler M, Bolker BM, Walker SC. Fitting linear mixed-effects models using lme4. J Stat Softw. 2015;67:1–48.

Article  Google Scholar 

Even PC, Nadkarni NA. Indirect calorimetry in laboratory mice and rats: principles, practical considerations, interpretation and perspectives. Am J Physiol Regul Integr Comp Physiol. 2012;303:R459–76.

Article  CAS  PubMed  Google Scholar 

Asgharpour A, Cazanave SC, Pacana T, Seneshaw M, Vincent R, Banini BA, et al. A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer. J Hepatol. 2016;65:579–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bailey CJ, Flatt PR, Conlon JM. An update on peptide-based therapies for type 2 diabetes and obesity. Peptides. 2023;161:170939.

Article  CAS  PubMed  Google Scholar 

Kiefer FW, Vernochet C, O’Brien P, Spoerl S, Brown JD, Nallamshetty S, et al. Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. Nature Med. 2012;18:918–25.

Article  CAS  PubMed  Google Scholar 

Yang D, Krois CR, Huang P, Wang J, Min J, Yoo HS, et al. Raldh1 promotes adiposity during adolescence independently of retinal signaling. PLoS ONE. 2017;12:e0187669.

Article  PubMed  PubMed Central  Google Scholar 

Zhang M, Hu P, Krois CR, Kane MA, Napoli JL. Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse. FASEB J. 2007;21:2886–96.

Article  CAS  PubMed  Google Scholar 

Berry DC, DeSantis D, Soltanian H, Croniger CM, Noy N. Retinoic acid upregulates preadipocyte genes to block adipogenesis and suppress diet-induced obesity. Diabetes. 2012;61:1112–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mody N. Alterations in vitamin A/retinoic acid homeostasis in diet-induced obesity and insulin resistance. Proc Nutr Soc. 2017;76:597–602.

Article  CAS  PubMed  Google Scholar 

Liu X, Cooper DE, Cluntun AA, Warmoes MO, Zhao S, Reid MA, et al. Acetate production from glucose and coupling to mitochondrial metabolism in mammals. Cell. 2018;175:502–13.e13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, et al. Acetate mediates a microbiome-brain-beta-cell axis to promote metabolic syndrome. Nature. 2016;534:213–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sahuri-Arisoylu M, Brody LP, Parkinson JR, Parkes H, Navaratnam N, Miller AD, et al. Reprogramming of hepatic fat accumulation and ‘browning’ of adipose tissue by the short-chain fatty acid acetate. Int J Obes. 2016;40:955–63.

Article  CAS  Google Scholar 

Sun W, Dong H, Wolfrum C. Local acetate inhibits brown adipose tissue function. Proc Natl Acad Sci USA. 2021;118:e2116125118.

Article  PubMed  PubMed Central  Google Scholar 

Sun W, Dong H, Balaz M, Slyper M, Drokhlyansky E, Colleluori G, et al. snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis. Nature. 2020;587:98–102.

Article  CAS  PubMed  Google Scholar 

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