Palsdottir K, Dagbjartsson A, Thorkelsson T, Hardardottir H (2007) Birth asphyxia and hypoxic ischemic encephalopathy, incidence and obstetric risk factors. Laeknabladid 93(9):595–601
Graham EM, Ruis KA, Hartman AL, Northington FJ, Fox HE (2008) A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy. Am J Obstet Gynecol 199(6):587–595. https://doi.org/10.1016/j.ajog.2008.06.094
Article CAS PubMed Google Scholar
MacDonald HM, Mulligan JC, Allen AC, Taylor PM (1980) Neonatal asphyxia. I. Relationship of obstetric and neonatal complications to neonatal mortality in 38,405 consecutive deliveries. J Pediatr 96(5):898–902. https://doi.org/10.1016/s0022-3476(80)80574-9
Article CAS PubMed Google Scholar
Ten VS, Starkov A (2012) Hypoxic-ischemic injury in the developing brain: the role of reactive oxygen species originating in mitochondria. Neurol Res. https://doi.org/10.1155/2012/542976
Ferriero DM (2004) Neonatal brain injury. N Engl J Med 351(19):1985–1995. https://doi.org/10.1056/nejmra041996
Article CAS PubMed Google Scholar
Koehn LM, Chen X, Logsdon AF, Lim Y-P, Stonestreet BS (2020) Novel neuroprotective agents to treat neonatal hypoxic-ischemic encephalopathy: inter-alpha inhibitor proteins. Int J Mol Sci. https://doi.org/10.3390/ijms21239193
Article PubMed PubMed Central Google Scholar
Disdier C, Zhang J, Fukunaga Y, Lim Y-P, Qiu J, Santoso A, Stonestreet BS (2018) Alterations in inter-alpha inhibitor protein expression after hypoxic-ischemic brain injury in neonatal rats. Int J Dev Neurosci 65:54–60. https://doi.org/10.1016/j.ijdevneu.2017.10.008
Article CAS PubMed Google Scholar
Baek YW, Brokat S, Padbury JF, Pinar H, Hixson DC, Lim Y-P (2003) Inter-α inhibitor proteins in infants and decreased levels in neonatal sepsis. J Pediatr 143(1):11–15. https://doi.org/10.1016/s0022-3476(03)00190-2
Article CAS PubMed Google Scholar
Chaaban H, Shin M, Sirya E, Lim Y-P, Caplan M, Padbury JF (2010) Inter-alpha inhibitor protein level in neonates predicts necrotizing enterocolitis. J Pediatr 157(5):757–761. https://doi.org/10.1016/j.jpeds.2010.04.075
Article CAS PubMed PubMed Central Google Scholar
Barrios-Anderson A, Chen X, Nakada S, Chen R, Lim Y-P, Stonestreet BS (2019) Inter-alpha inhibitor proteins modulate neuroinflammatory biomarkers after hypoxia-ischemia in neonatal rats. J Neuropathol Exp Neurol 78(8):742–755. https://doi.org/10.1093/jnen/nlz051
Article CAS PubMed PubMed Central Google Scholar
Chen X, Nakada S, Donahue JE, Chen RH, Tucker R, Qiu J, Lim Y-P, Stopa EG, Stonestreet BS (2019) Neuroprotective effects of inter-alpha inhibitor proteins after hypoxic-ischemic brain injury in neonatal rats. Exp Neurol 317:244–259. https://doi.org/10.1016/j.expneurol.2019.03.013
Article CAS PubMed PubMed Central Google Scholar
Gaudet CM, Lim Y-P, Stonestreet BS, Threlkeld SW (2016) Effects of age, experience and inter-alpha inhibitor proteins on working memory and neuronal plasticity after neonatal hypoxia-ischemia. Behav Brain Res 302:88–99. https://doi.org/10.1016/j.bbr.2016.01.016
Article CAS PubMed PubMed Central Google Scholar
Koehn LM, Nguyen K, Chen X, Santoso A, Tucker R, Lim Y-P, Stonestreet BS (2022) Effects of three different doses of inter-alpha inhibitor proteins on severe hypoxia–ischemia-related brain injury in neonatal rats. Int J Mol Sci. https://doi.org/10.3390/ijms232113473
Article PubMed PubMed Central Google Scholar
Schuffels S, Nakada S, Wu Y, Lim Y-P, Chen X, Stonestreet BS (2020) Effects of inter-alpha inhibitor proteins on brain injury after exposure of neonatal rats to severe hypoxia-ischemia. Exp Neurol. https://doi.org/10.1016/j.expneurol.2020.113442
Article PubMed PubMed Central Google Scholar
Threlkeld SW, Gaudet CM, La Rue ME, Dugas E, Hill CA, Lim Y-P, Stonestreet BS (2014) Effects of inter-alpha inhibitor proteins on neonatal brain injury: age, task and treatment dependent neurobehavioral outcomes. Exp Neurol 261:424–433. https://doi.org/10.1016/j.expneurol.2014.07.012
Article CAS PubMed Google Scholar
Threlkeld SW, Lim Y-P, La Rue M, Gaudet C, Stonestreet BS (2017) Immuno-modulator inter-alpha inhibitor proteins ameliorate complex auditory processing deficits in rats with neonatal hypoxic-ischemic brain injury. Brain Behav Immun 64:173–179. https://doi.org/10.1016/j.bbi.2017.03.004
Article CAS PubMed PubMed Central Google Scholar
McCullough LD, Roy-O’Reilly M, Lai Y-J, Patrizz A, Xu Y, Lee J, Holmes A, Kraushaar DC, Chauhan A, Sansing LH (2021) Exogenous inter-α inhibitor proteins prevent cell death and improve ischemic stroke outcomes in mice. J Clin Invest. https://doi.org/10.1172/JCI144898
Article PubMed PubMed Central Google Scholar
Levin VA (1980) Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. J Med Chem 23(6):682–684. https://doi.org/10.1021/jm00180a022
Article CAS PubMed Google Scholar
Banks WA, Kastin AJ (1990) Peptide transport systems for opiates across the blood-brain barrier. Am J Physiol Endocrinol Metab 259(1):E1–E10. https://doi.org/10.1152/ajpendo.1990.259.1.e1
Htwe SS, Wake H, Liu K, Teshigawara K, Stonestreet BS, Lim Y-P, Nishibori M (2018) Inter-α inhibitor proteins maintain neutrophils in a resting state by regulating shape and reducing ROS production. Blood Adv 2(15):1923–1934. https://doi.org/10.1182/bloodadvances.2018018986
Article CAS PubMed PubMed Central Google Scholar
Ek CJ, D’angelo B, Baburamani AA, Lehner C, Leverin A-L, Smith PL, Nilsson H, Svedin P, Hagberg H, Mallard C (2015) Brain barrier properties and cerebral blood flow in neonatal mice exposed to cerebral hypoxia-ischemia. J Cereb Blood Flow Metab 35(5):818–827. https://doi.org/10.1038/jcbfm.2014.255
Article CAS PubMed PubMed Central Google Scholar
Kumar A, Mittal R, Khanna HD, Basu S (2008) Free radical injury and blood-brain barrier permeability in hypoxic-ischemic encephalopathy. Pediatrics 122(3):e722–e727. https://doi.org/10.1542/peds.2008-0269
Chen X, Threlkeld SW, Cummings EE, Juan I, Makeyev O, Besio WG, Gaitanis J, Banks WA, Sadowska GB, Stonestreet BS (2012) Ischemia–reperfusion impairs blood–brain barrier function and alters tight junction protein expression in the ovine fetus. Neuroscience 226:89–100. https://doi.org/10.1016/j.neuroscience.2012.08.043
Article CAS PubMed Google Scholar
Stolp H, Dziegielewska K (2009) Role of developmental inflammation and blood–brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases. Neuropathol Appl Neurobiol 35(2):132–146. https://doi.org/10.1111/j.1365-2990.2008.01005.x
Article CAS PubMed Google Scholar
Logsdon AF, Erickson MA, Chen X, Qiu J, Lim Y-P, Stonestreet BS, Banks WA (2020) Inter-alpha inhibitor proteins attenuate lipopolysaccharide-induced blood–brain barrier disruption and downregulate circulating interleukin 6 in mice. J Cereb Blood Flow Metab 40(5):1090–1102. https://doi.org/10.1177/0271678x19859465
Article CAS PubMed Google Scholar
Logsdon A, Erickson M, Herbert M, Noonan C, Foresi B, Qiu J, Lim Y-P, Banks W, Stonestreet BS (2023) Inter-alpha inhibitor proteins attenuate lipopolysaccharide-induced blood-brain barrier disruption in neonatal mice. Exp Neurol. https://doi.org/10.1016/j.expneurol.2023.114563
Marchetti L, Engelhardt B (2020) Immune cell trafficking across the blood-brain barrier in the absence and presence of neuroinflammation. Vascular Biology 2(1):H1–H18. https://doi.org/10.1530/vb-19-0033
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