Galanello R, Origa R (2010) Beta-thalassemia. Orphanet J Rare Dis 5:11

Article  PubMed  PubMed Central  Google Scholar 

Kremastinos DT (2001) Heart failure in β-thalassemia. Congest Heart Fail 7:312–314

Article  PubMed  Google Scholar 

Ghanavat M, Haybar H, Pezeshki SMS et al (2020) Cardiomyopathy in thalassemia: quick review from cellular aspects to diagnosis and current treatments. Lab Med 51:143–150

PubMed  Google Scholar 

Albakri A (2018) Iron overload cardiomyopathy: a review of literature on clinical status and meta-analysis of diagnostic and clinical management using iron chelators. Int Med Care. https://doi.org/10.15761/IMC.1000117

Article  Google Scholar 

Kumfu S, Chattipakorn SC, Chattipakorn N (2022) Iron overload cardiomyopathy: using the latest evidence to inform future applications. Exp Biol Med (Maywood) 247:574–583

Article  CAS  PubMed  Google Scholar 

Borgna-Pignatti C, Rugolotto S, De Stefano P et al (2004) Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematologica 89:1187–1193

PubMed  Google Scholar 

Modell B, Khan M, Darlison M, Westwood MA, Ingram D, Pennell DJ (2008) Improved survival of thalassaemia major in the UK and relation to T2* cardiovascular magnetic resonance. J Cardiovasc Magn Reson 10:42

Article  PubMed  PubMed Central  Google Scholar 

Pepe A, Pistoia L, Gamberini MR et al (2022) National networking in rare diseases and reduction of cardiac burden in thalassemia major. Eur Heart J 43:2482–2492

Article  PubMed  Google Scholar 

McDonagh TA, Metra M, Adamo M et al (2021) 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the task force for the diagnosis and treatment of acute and chronic heart failure of the European society of cardiology (ESC) With the special contribution of the heart failure association (HFA) of the ESC. Eur Heart J 42:3599–3726

Article  CAS  PubMed  Google Scholar 

Heidenreich PA, Bozkurt B, Aguilar D et al (2022) 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American college of cardiology/American heart association joint committee on clinical practice guidelines. Circulation 145:e895–e1032

PubMed  Google Scholar 

Matusik PS, Bryll A, Matusik PT, Popiela TJ (2021) Ischemic and non-ischemic patterns of late gadolinium enhancement in heart failure with reduced ejection fraction. Cardiol J 28:67–76

Article  PubMed  PubMed Central  Google Scholar 

Meloni A, Saba L, Positano V et al (2024) Left atrial strain in patients with beta-thalassemia major: a cross-sectional CMR study. Eur Radiol. https://doi.org/10.1007/s00330-024-10667-x

Article  PubMed  Google Scholar 

Rezaeian N, Mohtasham MA, Khaleel AJ, Parnianfard N, Kasani K, Golshan R (2020) Comparison of global strain values of myocardium in beta-thalassemia major patients with iron load using specific feature tracking in cardiac magnetic resonance imaging. Int J Cardiovasc Imaging 36:1343–1349

Article  PubMed  Google Scholar 

Meloni A, Pistoia L, Positano V et al (2023) Increased myocardial extracellular volume is associated with myocardial iron overload and heart failure in thalassemia major. Eur Radiol 33:1266–1276

Article  CAS  PubMed  Google Scholar 

Meloni A, Pistoia L, Positano V et al (2023) Myocardial tissue characterization by segmental T2 mapping in thalassaemia major: detecting inflammation beyond iron. Eur Heart J Cardiovasc Imag 24:1222–1230

Article  Google Scholar 

Ibrahim HR, Ahmed AT (2023) Role of cardiac magnetic resonance T1 mapping in comparison to T2* for cardiac iron overload assessment in transfusion-dependent thalassemia major patients. Egy J Radiol Nucl Med 54:197

Article  Google Scholar 

Meloni A, Positano V, Ruffo GB et al (2015) Improvement of heart iron with preserved patterns of iron store by CMR-guided chelation therapy. Eur Heart J Cardiovasc Imag 16:325–334

Article  Google Scholar 

Miller CA, Pearce K, Jordan P et al (2012) Comparison of real-time three-dimensional echocardiography with cardiovascular magnetic resonance for left ventricular volumetric assessment in unselected patients. Eur Heart J Cardiovasc Imag 13:187–195

Article  Google Scholar 

Pennell DJ (2010) Cardiovascular magnetic resonance. Circulation 121:692–705

Article  PubMed  Google Scholar 

Anderson LJ, Holden S, Davis B et al (2001) Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 22:2171–2179

Article  CAS  PubMed  Google Scholar 

Tanner MA, Galanello R, Dessi C et al (2008) Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction. J Cardiovasc Magn Reson 10:12

Article  PubMed  PubMed Central  Google Scholar 

Anderson LJ, Westwood MA, Holden S et al (2004) Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: a prospective study using T2* cardiovascular magnetic resonance. Br J Haematol 127:348–355

Article  CAS  PubMed  Google Scholar 

Meloni A, Pistoia L, Gamberini MR et al (2023) Multi-parametric cardiac magnetic resonance for prediction of heart failure death in thalassemia major. Diagnostics (Basel) 13:890

Article  CAS  PubMed  Google Scholar 

Kawel-Boehm N, Hetzel SJ, Ambale-Venkatesh B et al (2020) Reference ranges (“normal values”) for cardiovascular magnetic resonance (CMR) in adults and children: 2020 update. J Cardiovasc Magn Reson 22:87

Article  PubMed  PubMed Central  Google Scholar 

Leiner T, Bogaert J, Friedrich MG et al (2020) SCMR Position Paper (2020) on clinical indications for cardiovascular magnetic resonance. J Cardiovasc Magn Reson 22:76

Article  PubMed  PubMed Central  Google Scholar 

Alpendurada F, Carpenter JP, Deac M et al (2010) Relation of myocardial T2* to right ventricular function in thalassaemia major. Eur Heart J 31:1648–1654

Article  PubMed  Google Scholar 

Liguori C, Pitocco F, Di Giampietro I et al (2015) Magnetic resonance comparison of left-right heart volumetric and functional parameters in thalassemia major and thalassemia intermedia patients. Biomed Res Int 2015:857642

Article  PubMed  PubMed Central  Google Scholar 

Westwood MA, Anderson LJ, Maceira AM et al (2007) Normalized left ventricular volumes and function in thalassemia major patients with normal myocardial iron. J Magn Reson Imaging 25:1147–1151

Article  PubMed  Google Scholar 

Carpenter JP, Alpendurada F, Deac M et al (2010) Right ventricular volumes and function in thalassemia major patients in the absence of myocardial iron overload. J Cardiovasc Magn Reson 12:24

Article  PubMed  PubMed Central  Google Scholar 

Meloni A, Righi R, Missere M et al (2021) Biventricular reference values by body surface area, age, and gender in a large cohort of well-treated thalassemia major patients without heart damage using a multiparametric CMR approach. J Magn Reson Imag 53:61–70

Article  Google Scholar 

Mewton N, Opdahl A, Choi EY et al (2013) Left ventricular global function index by magnetic resonance imaging–a novel marker for assessment of cardiac performance for the prediction of cardiovascular events: the multi-ethnic study of atherosclerosis. Hypertension 61:770–778

Article  CAS  PubMed  Google Scholar 

Meloni A, Positano V, Pistoia L et al (2023) Left ventricular global function index is associated with myocardial iron overload and heart failure in thalassemia major patients. Int J Cardiovasc Imaging 39:991–999

Article  PubMed  Google Scholar 

Pezel T, Venkatesh BA, Vasconcellos HDD et al (2021) Left atrioventricular coupling index as a prognostic marker of cardiovascular events: the MESA study. Hypertension 78:661–671

Article  CAS  PubMed  Google Scholar 

von Roeder M, Kowallick JT, Rommel K-P et al (2020) Right atrial–right ventricular coupling in heart failure with preserved ejection fraction. Clin Res Cardiol 109:54–66

Article  Google Scholar 

Meloni A, Saba L, Positano V et al (2024) Left and right atrioventricular coupling index in patients with beta-thalassemia major. Int J Cardiovasc Imaging. https://doi.org/10.1007/s10554-024-03146-3