Spitz S (1948) Melanomas of childhood. Am J Pathol 24(3):591–609

CAS  PubMed  PubMed Central  Google Scholar 

Kamino H, Flotte TJ, Misheloff E, Greco MA, Ackerman AB (1979) Eosinophilic globules in Spitz’s nevi. New findings and a diagnostic sign. Am J Dermatopathol 1(4):319–324

Article  CAS  PubMed  Google Scholar 

Bastian BC, LeBoit PE, Pinkel D (2000) Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features. Am J Pathol 157(3):967–972. https://doi.org/10.1016/S0002-9440(10)64609-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yazdan P, Cooper C, Sholl LM et al (2014) Comparative analysis of atypical spitz tumors with heterozygous versus homozygous 9p21 deletions for clinical outcomes, histomorphology, BRAF mutation, and p16 expression. Am J Surg Pathol 38(5):638–645. https://doi.org/10.1097/PAS.0000000000000160

Article  PubMed  Google Scholar 

Massi D, Tomasini C, Senetta R et al (2015) Atypical Spitz tumors in patients younger than 18 years. J Am Acad Dermatol 72(1):37–46. https://doi.org/10.1016/j.jaad.2014.09.049

Article  PubMed  Google Scholar 

Hawryluk EB, Moustafa D, Bartenstein D et al (2020) A retrospective multicenter study of fatal pediatric melanoma. J Am Acad Dermatol 83(5):1274–1281. https://doi.org/10.1016/j.jaad.2020.06.1010

Article  PubMed  Google Scholar 

Wiesner T, He J, Yelensky R et al (2014) Kinase fusions are frequent in Spitz tumours and spitzoid melanomas. Nat Commun 5:3116. https://doi.org/10.1038/ncomms4116

Article  CAS  PubMed  Google Scholar 

Sarin KY, McNiff JM, Kwok S, Kim J, Khavari PA (2014) Activating HRAS mutation in nevus spilus. J Invest Dermatol 134(6):1766–1768. https://doi.org/10.1038/jid.2014.6

Article  CAS  PubMed  Google Scholar 

Goto K, Pissaloux D, Fraitag S et al (2022) RASGRF1-rearranged cutaneous melanocytic neoplasms with Spitzoid cytomorphology: a clinicopathologic and genetic study of 3 cases. Am J Surg Pathol 46(5):655–663. https://doi.org/10.1097/PAS.0000000000001839

Article  PubMed  Google Scholar 

Houlier A, Pissaloux D, Tirode F et al (2021) RASGRF2 gene fusions identified in a variety of melanocytic lesions with distinct morphological features. Pigment Cell Melanoma Res 34(6):1074–1083. https://doi.org/10.1111/pcmr.13004

Article  CAS  PubMed  Google Scholar 

Sunshine JC, Kim D, Zhang B et al (2020) Melanocytic neoplasms with MAP2K1 in frame deletions and spitz morphology. Am J Dermatopathol 42(12):923–931. https://doi.org/10.1097/DAD.0000000000001795

Article  PubMed  PubMed Central  Google Scholar 

Raghavan SS, Kapler ES, Dinges MM, Bastian BC, Yeh I (2020) Eruptive Spitz nevus, a striking example of benign metastasis. Sci Rep 10(1):16216. https://doi.org/10.1038/s41598-020-73264-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goto K, Pissaloux D, Kauer F, Huriet V, Tirode F, de la Fouchardière A (2021) GOPC-ROS1 mosaicism in agminated Spitz naevi: report of two cases. Virchows Arch 479(3):559–564. https://doi.org/10.1007/s00428-020-02992-5

Article  CAS  PubMed  Google Scholar 

Goto K, Pissaloux D, Durand L, Tirode F, Guillot B, de la Fouchardière A (2020) Novel three-way complex rearrangement of TRPM1-PUM1-LCK in a case of agminated Spitz nevi arising in a giant congenital hyperpigmented macule. Pigment Cell Melanoma Res 33(5):767–772. https://doi.org/10.1111/pcmr.12884

Article  CAS  PubMed  Google Scholar 

Kervarrec T, Briand C, Pissaloux D et al (2022) Agminated Spitz naevus with an activating HRAS Q61R mutation. Pathology 54(3):374–376. https://doi.org/10.1016/j.pathol.2021.04.013

Article  CAS  PubMed  Google Scholar 

Kervarrec T, Pissaloux D, Tirode F et al (2022) Morphologic features in a series of 352 Spitz melanocytic proliferations help predict their oncogenic drivers. Virchows Arch 480(2):369–382. https://doi.org/10.1007/s00428-021-03227-x

Article  CAS  PubMed  Google Scholar 

Busam KJ, Kutzner H, Cerroni L, Wiesner T (2014) Clinical and pathologic findings of Spitz nevi and atypical Spitz tumors with ALK fusions. Am J Surg Pathol 38(7):925–933. https://doi.org/10.1097/PAS.0000000000000187

Article  PubMed  PubMed Central  Google Scholar 

Yeh I, de la Fouchardiere A, Pissaloux D et al (2015) Clinical, histopathologic, and genomic features of Spitz tumors with ALK fusions. Am J Surg Pathol 39(5):581–591. https://doi.org/10.1097/PAS.0000000000000387

Article  PubMed  PubMed Central  Google Scholar 

Amin SM, Haugh AM, Lee CY et al (2017) A comparison of morphologic and molecular features of BRAF, ALK, and NTRK1 fusion spitzoid neoplasms. Am J Surg Pathol 41(4):491–498. https://doi.org/10.1097/PAS.0000000000000761

Article  PubMed  Google Scholar 

Ren J, Ren M, Kong YY, Cai X, Kong JC (2019) Clinicopathological features and prognosis of ALK-positive Spitz tumors. Zhonghua Bing Li Xue Za Zhi 48(3):215–219. https://doi.org/10.3760/cma.j.issn.0529-5807.2019.03.009

Article  CAS  PubMed  Google Scholar 

Tetzlaff MT, Xu X, Elder DE, Elenitsas R (2009) Angiomatoid Spitz nevus: a clinicopathological study of six cases and a review of the literature. J Cutan Pathol 36(4):471–476. https://doi.org/10.1111/j.1600-0560.2008.01060.x

Article  PubMed  Google Scholar 

Diaz-Cascajo C, Borghi S, Weyers W (2000) Angiomatoid Spitz nevus: a distinct variant of desmoplastic Spitz nevus with prominent vasculature. Am J Dermatopathol 22(2):135–139. https://doi.org/10.1097/00000372-200004000-00008

Article  CAS  PubMed  Google Scholar 

Hilliard NJ, Krahl D, Sellheyer K (2009) p16 expression differentiates between desmoplastic Spitz nevus and desmoplastic melanoma. J Cutan Pathol 36(7):753–759. https://doi.org/10.1111/j.1600-0560.2008.01154.x

Article  PubMed  Google Scholar 

VandenBoom T, Quan VL, Zhang B et al (2018) Genomic fusions in pigmented spindle cell nevus of Reed. Am J Surg Pathol 42(8):1042–1051. https://doi.org/10.1097/PAS.0000000000001074

Article  PubMed  Google Scholar 

Paredes B, Hardmeier T (1998) Spitz nevus and Reed nevus: simulating melanoma in adults. Pathologe 19(6):403–411. https://doi.org/10.1007/s002920050304

Article  CAS  PubMed  Google Scholar 

Ferrara G, Argenziano G, Soyer HP et al (2005) The spectrum of Spitz nevi: a clinicopathologic study of 83 cases. Arch Dermatol 141(11):1381–1387. https://doi.org/10.1001/archderm.141.11.1381

Article  PubMed  Google Scholar 

Busam KJ, Barnhill RL (1995) Pagetoid Spitz nevus. Intraepidermal Spitz tumor with prominent pagetoid spread. Am J Surg Pathol 19(9):1061–1067

Article  CAS  PubMed  Google Scholar 

Fernandez AP, Billings SD, Bergfeld WF, Ko JS, Piliang MP (2016) Pagetoid Spitz nevi: clinicopathologic characterization of a series of 12 cases. J Cutan Pathol 43(11):932–939. https://doi.org/10.1111/cup.12774

Article  PubMed  Google Scholar 

de la Fouchardière A, Tee MK, Peternel S et al (2021) Fusion partners of NTRK3 affect subcellular localization of the fusion kinase and cytomorphology of melanocytes. Mod Pathol 34(4):735–747. https://doi.org/10.1038/s41379-020-00678-6

Article  CAS  PubMed  Google Scholar