Beechem JM (2020) High-plex spatially resolved RNA and protein detection using digital spatial profiling: a technology designed for immuno-oncology biomarker discovery and translational research. In: Thurin M, Cesano A, Marincola F (eds) Biomarkers for immunotherapy of cancer. Methods in Molecular Biolog 2055. Humana, New York, NY, USA. https://doi.org/10.1007/978-1-4939-9773-2_25
Rahman A, Jahangir C, Lynch SM et al (2020) Advances in tissue-based imaging: impact on oncology research and clinical practice. Expert Rev Mol Diagn 20:1027–1037. https://doi.org/10.1080/14737159.2020.1770599
Article PubMed CAS Google Scholar
Marx V (2021) Method of the year: spatially resolved transcriptomics. Nat Methods 18:9–14. https://doi.org/10.1038/s41592-020-01033-y
Article PubMed CAS Google Scholar
Blank CU, Rozeman EA, Fanchi LF et al (2018) Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma. Nat Med 24:1655–1661. https://doi.org/10.1038/s41591-018-0198-0
Article PubMed CAS Google Scholar
Amaria RN, Reddy SM, Tawbi HA et al (2018) Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma. Nat Med 24:1649–1654. https://doi.org/10.1038/s41591-018-0197-1
Article PubMed PubMed Central CAS Google Scholar
Toki MI, Merritt CR, Wong PF et al (2019) High-plex predictive marker discovery for melanoma immunotherapy-treated patients using digital spatial profiling. Clin Cancer Res 25:5503–5512. https://doi.org/10.1158/1078-0432.CCR-19-0104
Article PubMed PubMed Central CAS Google Scholar
McCart Reed AE, Bennett J, Kutasovic JR et al (2020) Digital spatial profiling application in breast cancer: a user’s perspective. Virchows Arch 477:885–890. https://doi.org/10.1007/s00428-020-02821-9
Stewart RL, Matynia AP, Factor RE, Varley KE (2020) Spatially-resolved quantification of proteins in triple negative breast cancer reveals differences in the immune microenviroment associated with prognosis. Sci Rep 10:6598. https://doi.org/10.1038/s41598-020-63539-x
Article PubMed PubMed Central CAS Google Scholar
Mc Namara KL, Caswell-Jin JL, Joshi R et al (2021) Spatial proteomic characterization of HER2-positive breast tumors through neoadiuvant therapy predicts response. Nat Cancer 2:400–413. https://doi.org/10.1038/s43018-021-00190-z
Article PubMed CAS Google Scholar
Bergholtz H, Carter JM, Cesano A et al (2021) Best practices for spatial profiling for breast cancer research with the GeoMx® Digital Spatial Profiler. Cancers 13:4456. https://doi.org/10.3390/cancers13174456
Article PubMed PubMed Central CAS Google Scholar
Carter JM, Polley M, Leon-Ferre RA et al (2021) Characteristics and spatially defined immune (micro)landscapes of early-stage PD-L1-positive triple-negative breast cancer. Clin Cancer Res 27:5628–5637. https://doi.org/10.1158/1078-0432.CCR-21-0343
Article PubMed PubMed Central CAS Google Scholar
Omilian AR, Sheng H, Hong CC et al (2022) Multiplexed digital spatial profiling of invasive breast tumors from black and white women. Mol Oncol 16:54–68. https://doi.org/10.1002/1878-0261.13017
Article PubMed CAS Google Scholar
Kulashinge A, Monkman J, Shah ET, Matigian N, Adams MN, O’Byrne K (2022) Spatial profiling identifies prognostic features of response to adjuvant therapy in triple negative breast cancer (TNBC). Front Oncol 11:798296. https://doi.org/10.3389/fonc.2021.798296
Donati B, Reggiani F, Torricelli F et al (2024) Spatial distribution of immune cells drives resistance to neoadjuvant chemotherapy in triple-negative breast cancer. Cancer Immunol Res 12:120–121. https://doi.org/10.1158/2326-6066.CIR-23-0076
Article PubMed CAS Google Scholar
Monkman J, Taheri T, Ebrahimi Warkiani M et al (2020) High-plex and high-throughput digital spatial profiling of non-small-cell lung cancer (NSCLC). Cancers 12:3551. https://doi.org/10.3390/cancers12123551
Article PubMed PubMed Central CAS Google Scholar
Zugazagoitia J, Gupta S, Liu Y et al (2020) Biomarkers associated with beneficial PD-1 checkpoint blockade in non-small cell lung cancer (NSCLC) identified using high-plex digital spatial profiling. Clin Cancer Res 26:4360–4368. https://doi.org/10.1158/1078-0432.CCR-20-0175
Article PubMed PubMed Central CAS Google Scholar
Kulasinghe A, Taheri T, O’Byrne K, Hughes BGM, Kenny L, Punyadeera C (2021) Highly multiplexed digital spatial profiling of the tumor microenvironment of head and neck squamous cell carcinoma patients. Front Oncol 10:607349. https://doi.org/10.3389/fonc.2020.607349
Article PubMed PubMed Central Google Scholar
Brady L, Kriner M, Coleman I et al (2021) Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling. Nat Commun 12:1426. https://doi.org/10.1038/s41467-021-21615-4
Article PubMed PubMed Central CAS Google Scholar
Pelka K, Hofree M, Chen JH et al (2021) Spatially organized multicellular immune hubs in human colorectal cancer. Cell 184:4734–52.e20. https://doi.org/10.1016/j.cell.2021.08.003
Article PubMed PubMed Central CAS Google Scholar
Aguado-Fraile E, Tassinari A, Ishii Y et al (2021) Molecular and morphological changes induced by ivosidenib correlate with efficacy in mutant-IDH1 cholangiocarcinoma. Future Oncol 17:2057–2074. https://doi.org/10.2217/fon-2020-1274
Article PubMed CAS Google Scholar
Torricelli F, Donati B, Reggiani F et al (2023) Spatially resolved, high-dimensional transcriptomics sorts out the evolution of biphasic malignant pleural mesothelioma: new paradigms for immunotherapy. Mol Cancer 22:114. https://doi.org/10.1186/s12943-023-01816-9
Article PubMed PubMed Central CAS Google Scholar
Hmeljak J, Sanchez-Vega F, Hoadley KA (2018) Integrative molecular characterization of malignant pleural mesothelioma. Cancer Discov 8:1548–1565. https://doi.org/10.1158/2159-8290.CD-18-0804
Article PubMed PubMed Central CAS Google Scholar
Barber H, Tofias A, Lander B et al (2021) Advanced molecular characterization using digital spatial profiling technology on immunooncology targets in methylated compared with unmethylated IDH-wildtype glioblastoma. J Oncol 8819702. https://doi.org/10.1155/2021/8819702
Hernandez S, Lazcano R, Serrano A et al (2022) Challenges and opportunities for immunoprofiling using a spatial high-plex technology: the NanoString GeoMx® Digital Spatial Profiler. Front Oncol 12:890410. https://doi.org/10.3389/fonc.2022.890410
Article PubMed PubMed Central CAS Google Scholar
Wang S, Jiang L, Han Y et al (2016) Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma. Oncotarget 7:69565–69578. https://doi.org/10.18632/oncotarget.11829
Article PubMed PubMed Central Google Scholar
Na TY, Schecterson L, Mendonsa AM, Gumbiner BM (2020) The functional activity of E-cadherin controls tumor cell metastasis at multiple steps. Proc Natl Acad Sci U S A 117:5931–5937. https://doi.org/10.1073/pnas.1918167117
Article PubMed PubMed Central CAS Google Scholar
Kaszak I, Witkowska-Piłaszewicz O, Niewiadomska Z, Dworecka-Kaszak B, Ngosa Toka F, Jurka P (2020) Role of cadherins in cancer-a review. Int J Mol Sci 21:7624. https://doi.org/10.3390/ijms21207624
Article PubMed PubMed Central CAS Google Scholar
Ragazzi M, Torricelli F, Donati B et al (2021) Coexisting well-differentiated and anaplastic thyroid carcinoma in the same primary resection specimen: immunophenotypic and genetic comparison of the two components in a consecutive series of 13 cases and a review of the literature. Virchows Arch 478:265–281. https://doi.org/10.1007/s00428-020-02891-9
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