Aisen PS, Cummings J, Jack CRJ, Morris JC, Sperling R, Frölich L, et al. On the path to 2025: understanding the Alzheimer’s disease continuum. Alzheimers Res Ther. 2017;9:60–5.

Article  PubMed  PubMed Central  Google Scholar 

Jessen F, Amariglio RE, van Boxtel M, Breteler M, Ceccaldi M, Chételat G, et al. Subjective Cognitive Decline Initiative (SCD-I) Working Group: A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease. Alzheimers Dement. 2014;10:844–52.

Article  PubMed  Google Scholar 

Wang X, Wang Z, Hu H, Qu Y, Wang M, Shen X, et al. Association of subjective cognitive decline with risk of cognitive impairment and dementia: a systematic review and meta-analysis of prospective longitudinal studies. J Prev Alzheimers Dis. 2021;8:277–85.

PubMed  Google Scholar 

Jessen F, Amariglio RE, Buckley RF, van der Flier WM, Han Y, Molinuevo JL, et al. The characterisation of subjective cognitive decline. Lancet Neurol. 2020;19:271–8.

Article  PubMed  PubMed Central  Google Scholar 

Li H, Tan C, Tan L, Xu W. Predictors of cognitive deterioration in subjective cognitive decline: evidence from longitudinal studies and implications for SCD-plus criteria. J Neurol Neurosurg Psychiatry. 2023;94:844–54.

Article  PubMed  Google Scholar 

Smart CM, Karr JE, Areshenkoff CN, Rabin LA, Hudon C, Gates N, et al. Non-pharmacologic interventions for older adults with subjective cognitive decline: systematic review, meta-analysis, and preliminary recommendations. Neuropsychol Rev. 2017;27:245–57.

Article  PubMed  Google Scholar 

Bhome R, Berry AJ, Huntley JD, Howard RJ. Interventions for subjective cognitive decline: systematic review and meta-analysis. BMJ Open. 2018;8:e021610-021610.

Article  PubMed  PubMed Central  Google Scholar 

Rajaram S, Jones J, Lee GJ. Plant-based dietary patterns, plant foods, and age-related cognitive decline. Adv Nutr. 2019;10:S422–36.

Article  PubMed  PubMed Central  Google Scholar 

Guarnieri L, Bosco F, Leo A, Citraro R, Palma E, De Sarro G, et al. Impact of micronutrients and nutraceuticals on cognitive function and performance in Alzheimer’s disease. Ageing Res Rev. 2024;95: 102210.

Article  CAS  PubMed  Google Scholar 

Krikorian R, Shidler MD, Summer SS. Early intervention in cognitive aging with strawberry supplementation. Nutrients. 2023;15:4431.

Article  CAS  PubMed  PubMed Central  Google Scholar 

do Rosario V, Lorzadeh E, Brodaty H, Anstey KJ, Chan K, Roodenrys S, et al. Assessing the effect of anthocyanins through diet and supplementation on cognitive function in older adults at risk for dementia: protocol for a randomised controlled trial. BMJ Open. 2024;14:e086435.

Article  PubMed  PubMed Central  Google Scholar 

Butler M, Nelson VA, Davila H, Ratner E, Fink HA, Hemmy LS, et al. Over-the-counter supplement interventions to prevent cognitive decline, mild cognitive impairment, and clinical alzheimer-type dementia: a systematic review. Ann Intern Med. 2018;168:52–62.

Article  PubMed  Google Scholar 

Fravel MA, Ernst ME, Gilmartin-Thomas J, Woods RL, Orchard SG, Owen AJ, ASPirin in Reducing Events in the Elderly Investigator Group. Dietary supplement and complementary and alternative medicine use among older adults in Australia and the United States. J Am Geriatr Soc. 2023;71:2219–28.

Article  PubMed  PubMed Central  Google Scholar 

Cave AE, Chang DH, Münch GW, Steiner-Lim GZ. A systematic review of the safety and efficacy on cognitive function of herbal and nutritional medicines in older adults with and without subjective cognitive impairment. Syst Rev. 2023;12:143–6.

Article  PubMed  PubMed Central  Google Scholar 

Costa JG, Vidovic B, Saraiva N, do Céu Costa M, Del Favero G, et al. Contaminants: a dark side of food supplements? Free Radic Res. 2019;53:1113–35.

Article  CAS  PubMed  Google Scholar 

Lockwood GB. The quality of commercially available nutraceutical supplements and food sources. J Pharm Pharmacol. 2011;63:3–10.

Article  CAS  PubMed  Google Scholar 

Galluzzi S, Zanardini R, Ferrari C, Gipponi S, Passeggia I, Rampini M, et al. Cognitive and biological effects of citrus phytochemicals in subjective cognitive decline: a 36-week, randomized, placebo-controlled trial. Nutr J. 2022;21:64–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gagnier JJ, Boon H, Rochon P, Moher D, Barnes J, Bombardier C. CONSORT Group: Recommendations for reporting randomized controlled trials of herbal interventions: Explanation and elaboration. J Clin Epidemiol. 2006;59:1134–49.

Article  PubMed  Google Scholar 

Ferry M, Coley N, Andrieu S, Bonhomme C, Caubère JP, Cesari M, et al. How to design nutritional intervention trials to slow cognitive decline in apparently healthy populations and apply for efficacy claims: a statement from the International Academy on Nutrition and Aging Task Force. J Nutr Health Aging. 2013;17:619–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Walia A, Mehra R, Kumar N, Singh TP, Kumar H. Good manufacturing practices and safety issues in functional foods and nutraceuticals. In: Bioactive components. Edited by Thakur M, Belwal T; 2023.

Haskell-Ramsay CF, Docherty S. Role of fruit and vegetables in sustaining healthy cognitive function: evidence and issues. Proc Nutr Soc. 2023;82:305–14.

Article  CAS  PubMed  Google Scholar 

Howes MR, Perry NSL, Vásquez-Londoño C, Perry EK. Role of phytochemicals as nutraceuticals for cognitive functions affected in ageing. Br J Pharmacol. 2020;177:1294–315.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Uçar K, Göktaş Z. Biological activities of naringenin: A narrative review based on in vitro and in vivo studies. Nutr Res. 2023;119:43–55.

Article  PubMed  Google Scholar 

Genovese S, Epifano F. Auraptene: a natural biologically active compound with multiple targets. Curr Drug Targets. 2011;12:381–6.

Article  CAS  PubMed  Google Scholar 

Zhou T, Liu L, Wang Q, Gao Y. Naringenin alleviates cognition deficits in high-fat diet-fed SAMP8 mice. J Food Biochem. 2020;44:e13375.

Article  CAS  PubMed  Google Scholar 

Ghanbarabadi M, Iranshahi M, Amoueian S, Mehri S, Motamedshariaty VS, Mohajeri SA. Neuroprotective and memory enhancing effects of auraptene in a rat model of vascular dementia: Experimental study and histopathological evaluation. Neurosci Lett. 2016;623:13–21.

Article  CAS  PubMed  Google Scholar 

Okuyama S, Katoh M, Kanzaki T, Kotani Y, Amakura Y, Yoshimura M, et al. Auraptene/Naringin-Rich Fruit Juice of Citrus kawachiensis (Kawachi Bankan) Prevents Ischemia-Induced Neuronal Cell Death in Mouse Brain through Anti-Inflammatory Responses. J Nutr Sci Vitaminol (Tokyo). 2019;65:66–71.

Article  CAS  PubMed  Google Scholar 

La VD, Zhao L, Epifano F, Genovese S, Grenier D. Anti-inflammatory and wound healing potential of citrus auraptene. J Med Food. 2013;16:961–4.

Article  CAS  PubMed  Google Scholar 

Bodet C, La VD, Epifano F, Grenier D. Naringenin has anti-inflammatory properties in macrophage and ex vivo human whole-blood models. J Periodontal Res. 2008;43:400–7.

Article  CAS  PubMed  Google Scholar 

Gahtan E, Overmier JB. Inflammatory pathogenesis in Alzheimer’s disease: biological mechanisms and cognitive sequeli. Neurosci Biobehav Rev. 1999;23:615–33.

Article  CAS  PubMed  Google Scholar 

Galimberti D, Schoonenboom N, Scarpini E, Scheltens P. Dutch-Italian Alzheimer Research Group: Chemokines in serum and cerebrospinal fluid of Alzheimer’s disease patients. Ann Neurol. 2003;53:547–8.

Article  PubMed  Google Scholar 

Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1982;17:37–49.