Sprung J, Roberts RO, Weingarten TN et al (2017) Postoperative delirium in elderly patients is associated with subsequent cognitive impairment. Br J Anaesth 119:316–323. https://doi.org/10.1093/bja/aex130

Article  CAS  PubMed  Google Scholar 

Inouye SK, Westendorp RG, Saczynski JS (2014) Delirium in elderly people. Lancet 383:911–922. https://doi.org/10.1016/S0140-6736(13)60688-1

Article  PubMed  Google Scholar 

Massarweh NN, Legner VJ, Symons RG et al (2009) Impact of advancing age on abdominal surgical outcomes. Arch Surg (Chic 1960) 144:1108. https://doi.org/10.1001/archsurg.2009.204

Article  Google Scholar 

Girard S, Brough D, Lopez-Castejon G et al (2013) Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices. Glia 61:813–824. https://doi.org/10.1002/glia.22478

Article  PubMed  PubMed Central  Google Scholar 

Maldonado JR (2013) Neuropathogenesis of delirium: review of current etiologic theories and common pathways. Am J Geriatr Psychiatry 21:1190–1222. https://doi.org/10.1016/j.jagp.2013.09.005

Article  PubMed  Google Scholar 

Saxena S, Maze M (2018) Impact on the brain of the inflammatory response to surgery. La Presse Méd (1983) 47:e73–e81. https://doi.org/10.1016/j.lpm.2018.03.011

Article  Google Scholar 

Liu Y, Fu H, Wang T (2022) Neuroinflammation in perioperative neurocognitive disorders: from bench to the bedside. CNS Neurosci Ther 28:484–496. https://doi.org/10.1111/cns.13794

Article  PubMed  PubMed Central  Google Scholar 

Skvarc DR, Berk M, Byrne LK et al (2018) Post-operative cognitive dysfunction: an exploration of the inflammatory hypothesis and novel therapies. Neurosci Biobehav Rev 84:116–133. https://doi.org/10.1016/j.neubiorev.2017.11.011

Article  PubMed  Google Scholar 

Liu L, Shang L, Jin D et al (2022) General anesthesia bullies the gut: a toxic relationship with dysbiosis and cognitive dysfunction. Psychopharmacology 239:709–728. https://doi.org/10.1007/s00213-022-06096-7

Article  CAS  PubMed  Google Scholar 

Heitor SP, De Souza CF (2016) Immunopathogenesis of IBD: current state of the art. Nat Rev Gastroenterol Hepatol 1:13–27. https://doi.org/10.1038/nrgastro.2016.186

Article  Google Scholar 

Barichello T, Giridharan VV, Catalão CHR et al (2023) Neurochemical effects of sepsis on the brain. Clin Sci (Lond) 137:401–414. https://doi.org/10.1042/CS20220549

Article  CAS  PubMed  Google Scholar 

Jiang XL, Gu XY, Zhou XX et al (2019) Intestinal dysbacteriosis mediates the reference memory deficit induced by anaesthesia/surgery in aged mice. Brain Behav Immun 80:605–615. https://doi.org/10.1016/j.bbi.2019.05.006

Article  CAS  PubMed  Google Scholar 

Zhang Y, Baldyga K, Dong Y et al (2023) The association between gut microbiota and postoperative delirium in patients. Transl Psychiatry 13:156. https://doi.org/10.1038/s41398-023-02450-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Johnson ECB, Dammer EB, Duong DM et al (2020) Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation. Nat Med 26:769–780. https://doi.org/10.1038/s41591-020-0815-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu JD, Bayir HO, Cosby DE et al (2017) Evaluation of encapsulated sodium butyrate on growth performance, energy digestibility, gut development, and Salmonella colonization in broilers. Poult Sci 96:3638–3644. https://doi.org/10.3382/ps/pex174

Article  CAS  PubMed  Google Scholar 

Dou X, Gao N, Yan D et al (2020) Sodium butyrate alleviates mouse colitis by regulating gut microbiota dysbiosis. Animals (Basel) 10:1154. https://doi.org/10.3390/ani10071154

Article  PubMed  Google Scholar 

Zhang Y, Xu S, Qian Y et al (2023) Sodium butyrate ameliorates gut dysfunction and motor deficits in a mouse model of Parkinson’s disease by regulating gut microbiota. Front Aging Neurosci. https://doi.org/10.3389/fnagi.2023.1099018

Article  PubMed  PubMed Central  Google Scholar 

Peng M, Zhang C, Dong Y et al (2016) Battery of behavioral tests in mice to study postoperative delirium. Sci Rep. https://doi.org/10.1038/srep29874

Article  PubMed  PubMed Central  Google Scholar 

Jia X, Song Y, Li Z et al (2024) Melatonin regulates the circadian rhythm to ameliorate postoperative sleep disorder and neurobehavioral abnormalities in aged mice. CNS Neurosci Ther. https://doi.org/10.1111/cns.14436

Article  PubMed  PubMed Central  Google Scholar 

Yu L, Wen G, Zhu S et al (2021) Abnormal phosphorylation of tau protein and neuroinflammation induced by laparotomy in an animal model of postoperative delirium. Exp Brain Res 239:867–880. https://doi.org/10.1007/s00221-020-06007-2

Article  CAS  PubMed  Google Scholar 

Xu R-C, Miao W, Xu J et al (2022) Neuroprotective effects of sodium butyrate and monomethyl fumarate treatment through GPR109a modulation and intestinal barrier restoration on PD mice. Nutrients 14:4163. https://doi.org/10.3390/nu14194163

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu J, Shen Q, Zhang H et al (2021) The potential protective effect of mesencephalic astrocyte-derived neurotrophic factor on post-operative delirium via inhibiting inflammation and microglia activation. J Inflamm Res 14:2781–2791. https://doi.org/10.2147/JIR.S316560

Article  PubMed  PubMed Central  Google Scholar 

Kraeuter A, Guest PC, Sarnyai Z (2019) The Y-maze for assessment of spatial working and reference memory in mice. Springer, New York, pp 105–111. https://doi.org/10.1007/978-1-4939-8994-2_10

Book  Google Scholar 

Shalaby RA, Qureshi MM, Khan MA et al (2023) Photobiomodulation therapy restores olfactory function impaired by photothrombosis in mouse olfactory bulb. Exp Neurol 367:114462. https://doi.org/10.1016/j.expneurol.2023.114462

Article  CAS  PubMed  Google Scholar 

Shi Z, Kong Q, Li X et al (2022) The effects of DNA extraction kits and primers on prokaryotic and eukaryotic microbial community in freshwater sediments. Microorganisms 10:1213. https://doi.org/10.3390/microorganisms10061213

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang C, Zheng D, Weng F et al (2022) Sodium butyrate ameliorates the cognitive impairment of Alzheimer’s disease by regulating the metabolism of astrocytes. Psychopharmacology 239:215–227. https://doi.org/10.1007/s00213-021-06025-0

Article  CAS  PubMed  Google Scholar 

Cristiano C, Cuozzo M, Coretti L et al (2022) Oral sodium butyrate supplementation ameliorates paclitaxel-induced behavioral and intestinal dysfunction. Biomed Pharmacother 153:113528. https://doi.org/10.1016/j.biopha.2022.113528

Article  CAS  PubMed  Google Scholar 

Fernando WMAD, Martins IJ, Morici M et al (2020) Sodium butyrate reduces brain amyloid-β levels and improves cognitive memory performance in an Alzheimer’s disease transgenic mouse model at an early disease stage. J Alzheimer’s Dis 74:91–99. https://doi.org/10.3233/JAD-190120

Article  CAS  Google Scholar 

Carr ZJ, Cios TJ, Potter KF et al (2018) Does dexmedetomidine ameliorate postoperative cognitive dysfunction? A brief review of the recent literature. Curr Neurol Neurosci Rep. https://doi.org/10.1007/s11910-018-0873-z

Article  PubMed  Google Scholar 

Cibelli M, Fidalgo AR, Terrando N et al (2010) Role of interleukin-1b in postoperative cognitive dysfunction. Ann Neurol 68:360–368. https://doi.org/10.1002/ana.22082

Article