Furman, D. et al. Chronic inflammation in the etiology of disease across the life span. Nat. Med. 25, 1822–1832 (2019). This manuscript offers a comprehensive review of the role of chronic low-grade inflammation in systemic disease, including obesity-related pathophysiologies.
Article CAS PubMed PubMed Central Google Scholar
Bradley, D., Deng, T., Shantaram, D. & Hsueh, W. A. Orchestration of the adipose tissue immune landscape by adipocytes. Annu. Rev. Physiol. 86, 199–223 (2024).
Article CAS PubMed Google Scholar
Hagberg, C. E. & Spalding, K. L. White adipocyte dysfunction and obesity-associated pathologies in humans. Nat. Rev. Mol. Cell Biol. 25, 270–289 (2024).
Article CAS PubMed Google Scholar
Reilly, S. M. & Saltiel, A. R. Adapting to obesity with adipose tissue inflammation. Nat. Rev. Endocrinol. 13, 633–643 (2017).
Article CAS PubMed Google Scholar
Shaikh, S. R., Beck, M. A., Alwarawrah, Y. & MacIver, N. J. Emerging mechanisms of obesity-associated immune dysfunction. Nat. Rev. Endocrinol. 20, 136–148 (2024).
Article CAS PubMed Google Scholar
Xourafa, G., Korbmacher, M. & Roden, M. Inter-organ crosstalk during development and progression of type 2 diabetes mellitus. Nat. Rev. Endocrinol. 20, 27–49 (2024).
Everett, B. M. et al. Anti-inflammatory therapy with canakinumab for the prevention and management of diabetes. J. Am. Coll. Cardiol. 71, 2392–2401 (2018). This study shows that although inhibiting IL-1β in patients who have had a myocardial infarction and CRP levels ≥2 mg/l prevents further cardiovascular events, it has no effect on reducing their risk of developing diabetes mellitus.
Article CAS PubMed Google Scholar
Li, D., Zhong, J., Zhang, Q. & Zhang, J. Effects of anti-inflammatory therapies on glycemic control in type 2 diabetes mellitus. Front. Immunol. 14, 1125116 (2023).
Article CAS PubMed PubMed Central Google Scholar
Ridker, P. M. et al. Antiinflammatory therapy with canakinumab for atherosclerotic disease. N. Engl. J. Med. 377, 1119–1131 (2017). This study provides definitive evidence that inhibiting IL-1β in patients who have had a myocardial infarction and CRP levels ≥2 mg/l prevents further cardiovascular events.
Article CAS PubMed Google Scholar
Antonelli, M. & Kushner, I. It’s time to redefine inflammation. FASEB J. 31, 1787–1791 (2017).
Article CAS PubMed Google Scholar
Medzhitov, R. The spectrum of inflammatory responses. Science 374, 1070–1075 (2021).
Article CAS PubMed Google Scholar
Meizlish, M. L., Franklin, R. A., Zhou, X. & Medzhitov, R. Tissue homeostasis and inflammation. Annu. Rev. Immunol. 39, 557–581 (2021).
Article CAS PubMed Google Scholar
Sugimoto, M. A., Sousa, L. P., Pinho, V., Perretti, M. & Teixeira, M. M. Resolution of inflammation: what controls its onset? Front. Immunol. 7, 160 (2016).
Article PubMed PubMed Central Google Scholar
Serhan, C. N. Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology. Mol. Asp. Med. 58, 1–11 (2017).
Wallace, J. L., Ianaro, A., Flannigan, K. L. & Cirino, G. Gaseous mediators in resolution of inflammation. Semin. Immunol. 27, 227–233 (2015).
Article CAS PubMed Google Scholar
Perretti, M. & D’Acquisto, F. Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. Nat. Rev. Immunol. 9, 62–70 (2009).
Article CAS PubMed Google Scholar
Schett, G. & Neurath, M. F. Resolution of chronic inflammatory disease: universal and tissue-specific concepts. Nat. Commun. 9, 3261 (2018).
Article PubMed PubMed Central Google Scholar
Brennan, E., Kantharidis, P., Cooper, M. E. & Godson, C. Pro-resolving lipid mediators: regulators of inflammation, metabolism and kidney function. Nat. Rev. Nephrol. 17, 725–739 (2021).
Article CAS PubMed PubMed Central Google Scholar
Chiang, N. & Serhan, C. N. Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors. Mol. Asp. Med. 58, 114–129 (2017). This review provides an elegant and comprehensive overview of the synthesis, receptors and function of SPMs.
Fredman, G. & Serhan, C. N. Specialized pro-resolving mediators in vascular inflammation and atherosclerotic cardiovascular disease. Nat. Rev. Cardiol. https://doi.org/10.1038/s41569-023-00984-x (2024).
Panigrahy, D., Gilligan, M. M., Serhan, C. N. & Kashfi, K. Resolution of inflammation: an organizing principle in biology and medicine. Pharmacol. Ther. 227, 107879 (2021).
Article CAS PubMed Google Scholar
Pirault, J. & Back, M. Lipoxin and resolvin receptors transducing the resolution of inflammation in cardiovascular disease. Front. Pharmacol. 9, 1273 (2018).
Article CAS PubMed PubMed Central Google Scholar
Dalli, J. & Serhan, C. N. Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators. Blood 120, e60–e72 (2012).
Article CAS PubMed PubMed Central Google Scholar
Doran, A. C., Yurdagul, A. Jr. & Tabas, I. Efferocytosis in health and disease. Nat. Rev. Immunol. 20, 254–267 (2020).
Article CAS PubMed Google Scholar
Julliard, W. A. et al. Specialized pro-resolving mediators as modulators of immune responses. Semin. Immunol. 59, 101605 (2022).
Article CAS PubMed PubMed Central Google Scholar
Borgeson, E. et al. Lipoxin A4 attenuates obesity-induced adipose inflammation and associated liver and kidney disease. Cell Metab. 22, 125–137 (2015). This study shows that lipoxin treatment of mice alleviates obesity-related adipose tissue inflammation, as well as kidney and liver disease.
Article CAS PubMed PubMed Central Google Scholar
Borgeson, E. et al. Lipoxin A4 attenuates adipose inflammation. FASEB J. 26, 4287–4294 (2012).
Article CAS PubMed Google Scholar
Cheng, T. et al. Resolvin D1 improves the Treg/Th17 imbalance in systemic lupus erythematosus through miR-30e-5p. Front. Immunol. 12, 668760 (2021).
Article CAS PubMed PubMed Central Google Scholar
Perez-Hernandez, J., Chiurchiu, V., Perruche, S. & You, S. Regulation of T-cell immune responses by pro-resolving lipid mediators. Front. Immunol. 12, 768133 (2021).
Article CAS PubMed PubMed Central Google Scholar
Ramon, S., Bancos, S., Serhan, C. N. & Phipps, R. P. Lipoxin A4 modulates adaptive immunity by decreasing memory B-cell responses via an ALX/FPR2-dependent mechanism. Eur. J. Immunol. 44, 357–369 (2014).
Article CAS PubMed PubMed Central Google Scholar
Kim, N. et al. Lipoxin B4 enhances human memory B cell antibody production via upregulating cyclooxygenase-2 expression. J. Immunol. 201, 3343–3351 (2018).
Article CAS PubMed Google Scholar
Ramon, S., Gao, F., Serhan, C. N. & Phipps, R. P. Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells. J. Immunol. 189, 1036–1042 (2012).
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