Golub IS, Termeie OG, Kristo S, Schroeder LP, Lakshmanan S, Shafter AM, et al. Major global coronary artery calcium guidelines. JACC Cardiovasc Imaging. 2023;16:98–117. https://doi.org/10.1016/j.jcmg.2022.06.018.

Article  PubMed  Google Scholar 

Knuuti J, Wijns W, Saraste A, Capodanno D, Barbato E, Funck-Brentano C, et al. 2019 ESC guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J. 2020;41:407–77. https://doi.org/10.1093/eurheartj/ehz425.

Article  PubMed  Google Scholar 

Patel J, Pallazola VA, Dudum R, Greenland P, McEvoy JW, Blumenthal RS, et al. Assessment of coronary artery calcium scoring to guide statin therapy allocation according to risk-enhancing factors: the multi-ethnic study of atherosclerosis. JAMA Cardiol. 2021;6:1161–70. https://doi.org/10.1001/jamacardio.2021.2321.

Article  PubMed  Google Scholar 

van der Aalst CM, Denissen S, Vonder M, Gratama JWC, Adriaansen HJ, Kuijpers D, et al. Screening for cardiovascular disease risk using traditional risk factor assessment or coronary artery calcium scoring: the ROBINSCA trial. Eur Heart J Cardiovasc Imaging. 2020;21:1216–24. https://doi.org/10.1093/ehjci/jeaa168.

Article  PubMed  Google Scholar 

Miller RJH, Pieszko K, Shanbhag A, Feher A, Lemley M, Killekar A, et al. Deep learning coronary artery calcium scores from SPECT/CT attenuation maps improve prediction of major adverse cardiac events. J Nucl Med. 2023;64:652–8. https://doi.org/10.2967/jnumed.122.264423.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Patchett ND, Pawar S, Miller EJ. Visual identification of coronary calcifications on attenuation correction CT improves diagnostic accuracy of SPECT/CT myocardial perfusion imaging. J Nucl Cardiol. 2017;24:711–20. https://doi.org/10.1007/s12350-016-0395-5.

Article  PubMed  Google Scholar 

Selvaraj S, Khan MS, Vidula MK, Wiener PC, de Feria AE, Rojulpote C, et al. Incremental prognostic value of visually estimated coronary artery calcium in patients undergoing positron emission tomography imaging. Open Heart. 2021;8:e001648. https://doi.org/10.1136/openhrt-2021-001648.

Article  PubMed  PubMed Central  Google Scholar 

Trpkov C, Savtchenko A, Liang Z, Feng P, Southern DA, Wilton SB, et al. Visually estimated coronary artery calcium score improves SPECT-MPI risk stratification. Int J Cardiol Heart Vasc. 2021;35:100827. https://doi.org/10.1016/j.ijcha.2021.100827.

Article  PubMed  PubMed Central  Google Scholar 

Engbers EM, Timmer JR, Ottervanger JP, Mouden M, Knollema S, Jager PL. Prognostic value of coronary artery calcium scoring in addition to single-photon emission computed tomographic myocardial perfusion imaging in symptomatic patients. Circ Cardiovasc Imaging. 2016;9:e003966. https://doi.org/10.1161/CIRCIMAGING.115.003966.

Article  PubMed  Google Scholar 

Pieszko K, Shanbhag AD, Lemley M, Hyun M, Van Kriekinge S, Otaki Y, et al. Reproducibility of quantitative coronary calcium scoring from PET/CT attenuation maps: comparison to ECG-gated CT scans. Eur J Nucl Med Mol Imaging. 2022;49:4122–32. https://doi.org/10.1007/s00259-022-05866-x.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Abdelrahman K, Shiyovich A, Huck DM, Berman AN, Weber B, Gupta S, et al. Artificial intelligence in coronary artery calcium scoring detection and quantification. Diagnostics (Basel). 2024;14:125. https://doi.org/10.3390/diagnostics14020125.

Article  PubMed  Google Scholar 

DeGrado TR, Hanson MW, Turkington TG, Delong DM, Brezinski DA, Vallee JP, et al. Estimation of myocardial blood flow for longitudinal studies with 13N-labeled ammonia and positron emission tomography. J Nucl Cardiol. 1996;3:494–507. https://doi.org/10.1016/s1071-3581(96)90059-8.

Article  PubMed  CAS  Google Scholar 

Gould KL, Johnson NP, Roby AE, Bui L, Kitkungvan D, Patel MB, et al. Coronary flow capacity and survival prediction after revascularization: physiological basis and clinical implications. Eur Heart J. 2024;45:181–94. https://doi.org/10.1093/eurheartj/ehad579.

Article  PubMed  Google Scholar 

Miura S, Naya M, Kumamaru H, Ando A, Miyazaki C, Yamashita T. Prognostic value of modified coronary flow capacity by 13N-ammonia myocardial perfusion positron emission tomography in patients without obstructive coronary arteries. J Cardiol. 2022;79:247–56. https://doi.org/10.1016/j.jjcc.2021.09.001.

Article  PubMed  Google Scholar 

Frey SM, Honegger U, Clerc OF, Caobelli F, Haaf P, Zellweger MJ. Left ventricular ejection fraction, myocardial blood flow and hemodynamic variables in adenosine and regadenoson vasodilator 82-Rubidium PET. J Nucl Cardiol. 2022;29:921–33. https://doi.org/10.1007/s12350-021-02729-0.

Article  PubMed  Google Scholar 

Kato T, Momose M, Uemura Y, Naya M, Matsumoto N, Hida S, et al. Association of the extent of myocardial ischemia with outcomes in patients with suspected coronary artery disease in Japan. J Cardiol. 2022;80:475–81. https://doi.org/10.1016/j.jjcc.2022.06.012.

Article  PubMed  Google Scholar 

Aldana-Bitar J, Cho GW, Anderson L, Karlsberg DW, Manubolu VS, Verghese D, et al. Artificial intelligence using a deep learning versus expert computed tomography human reading in calcium score and coronary artery calcium data and reporting system classification. Coron Artery Dis. 2023;34:448–52. https://doi.org/10.1097/MCA.0000000000001244.

Article  PubMed  Google Scholar 

Lee JG, Kim H, Kang H, Koo HJ, Kang JW, Kim YH, et al. Fully automatic coronary calcium score software empowered by artificial intelligence technology: validation study using three CT cohorts. Korean J Radiol. 2021;22:1764–76. https://doi.org/10.3348/kjr.2021.0148.

Article  PubMed  PubMed Central  Google Scholar 

Perrone-Filardi P, Achenbach S, Mohlenkamp S, Reiner Z, Sambuceti G, Schuijf JD, et al. Cardiac computed tomography and myocardial perfusion scintigraphy for risk stratification in asymptomatic individuals without known cardiovascular disease: a position statement of the Working Group on Nuclear Cardiology and Cardiac CT of the European Society of Cardiology. Eur Heart J. 2011;32:1986–93. https://doi.org/10.1093/eurheartj/ehq235.

Article  PubMed  Google Scholar 

Duan J, Zhu L, Shi Y, Wang W, Wang T, Ning T, et al. Chemotherapy re-use versus anti-angiogenic monotherapy as the third-line treatment of patients with metastatic colorectal cancer: a real-world cohort study. BMC Cancer. 2024;24:302. https://doi.org/10.1186/s12885-024-12072-5.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Danad I, Raijmakers PG, Appelman YE, Harms HJ, de Haan S, Marques KM, et al. Quantitative relationship between coronary artery calcium score and hyperemic myocardial blood flow as assessed by hybrid 15O-water PET/CT imaging in patients evaluated for coronary artery disease. J Nucl Cardiol. 2012;19:256–64. https://doi.org/10.1007/s12350-011-9476-7.

Article  PubMed  Google Scholar 

Naya M, Murthy VL, Foster CR, Gaber M, Klein J, Hainer J, et al. Prognostic interplay of coronary artery calcification and underlying vascular dysfunction in patients with suspected coronary artery disease. J Am Coll Cardiol. 2013;61:2098–106. https://doi.org/10.1016/j.jacc.2013.02.029.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gould KL, Johnson NP, Roby AE, Nguyen T, Kirkeeide R, Haynie M, et al. Regional, artery-specific thresholds of quantitative myocardial perfusion by PET associated with reduced myocardial infarction and death after revascularization in stable coronary artery disease. J Nucl Med. 2019;60:410–7. https://doi.org/10.2967/jnumed.118.211953.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gould KL, Kitkungvan D, Johnson NP, Nguyen T, Kirkeeide R, Bui L, et al. Mortality prediction by quantitative PET perfusion expressed as coronary flow capacity with and without revascularization. JACC Cardiovasc Imaging. 2021;14:1020–34. https://doi.org/10.1016/j.jcmg.2020.08.040.

Article  PubMed  Google Scholar 

Pieszko K, Shanbhag A, Killekar A, Miller RJH, Lemley M, Otaki Y, et al. Deep learning of coronary calcium scores from PET/CT attenuation maps accurately predicts adverse cardiovascular events. JACC Cardiovasc Imaging. 2023;16:675–87. https://doi.org/10.1016/j.jcmg.2022.06.006.

Article  PubMed  Google Scholar 

Feher A, Pieszko K, Miller R, Lemley M, Shanbhag A, Huang C, et al. Integration of coronary artery calcium scoring from CT attenuation scans by machine learning improves prediction of adverse cardiovascular events in patients undergoing SPECT/CT myocardial perfusion imaging. J Nucl Cardiol. 2023;30:590–603. https://doi.org/10.1007/s12350-022-03099-x.

Article  PubMed  Google Scholar 

Lehtonen E, Kujala I, Tamminen J, Maaniitty T, Saraste A, Teuho J, et al. Incremental prognostic value of downstream positron emission tomography perfusion imaging after coronary computed tomography angiography: a study using machine learning. Eur Heart J Cardiovasc Imaging. 2024;25:285–92. https://doi.org/10.1093/ehjci/jead246.

Article  PubMed  Google Scholar 

Patel KK, Peri-Okonny PA, Qarajeh R, Patel FS, Sperry BW