Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.

Article  PubMed  Google Scholar 

Leiter A, Veluswamy RR, Wisnivesky JP. The global burden of lung cancer: current status and future trends. Nat Rev Clin Oncol. 2023;20(9):624–39.

Article  PubMed  Google Scholar 

Nooreldeen R, Bach H. Current and Future Development in Lung Cancer diagnosis. Int J Mol Sci 2021;22(16).

Yang CY, Lin YT, Lin LJ, Chang YH, Chen HY, Wang YP, Shih JY, Yu CJ, Yang PC. Stage Shift improves Lung Cancer Survival: real-world evidence. J Thorac Oncol. 2023;18(1):47–56.

Article  PubMed  Google Scholar 

Luo YH, Luo L, Wampfler JA, Wang Y, Liu D, Chen YM, Adjei AA, Midthun DE, Yang P. 5-year overall survival in patients with lung cancer eligible or ineligible for screening according to US Preventive Services Task Force criteria: a prospective, observational cohort study. Lancet Oncol. 2019;20(8):1098–108.

Article  PubMed  PubMed Central  Google Scholar 

Balata H, Quaife SL, Craig C, Ryan DJ, Bradley P, Crosbie PAJ, Murray RL, Evison M. Early diagnosis and Lung Cancer Screening. Clin Oncol-Uk. 2022;34(11):708–15.

Article  CAS  Google Scholar 

Jonas DE, Reuland DS, Reddy SM, Nagle M, Clark SD, Weber RP, Enyioha C, Malo TL, Brenner AT, Armstrong C, et al. Screening for Lung Cancer with Low-Dose computed Tomography updated evidence report and systematic review for the US Preventive Services Task Force. Jama-J Am Med Assoc. 2021;325(10):971–87.

Article  Google Scholar 

Huang ZH, Du YP, Wen JT, Lu BF, Zhao Y. snoRNAs: functions and mechanisms in biological processes, and roles in tumor pathophysiology. Cell Death Discov. 2022;8(1):259.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kiss T. Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions. Cell. 2002;109(2):145–8.

Article  CAS  PubMed  Google Scholar 

Wang K, Wang S, Zhang Y, Xie L, Song X, Song X. SNORD88C guided 2’-O-methylation of 28S rRNA regulates SCD1 translation to inhibit autophagy and promote growth and metastasis in non-small cell lung cancer. Cell Death Differ. 2023;30(2):341–55.

Article  CAS  PubMed  Google Scholar 

Cui C, Liu Y, Gerloff D, Rohde C, Pauli C, Kohn M, Misiak D, Oellerich T, Schwartz S, Schmidt LH, et al. NOP10 predicts lung cancer prognosis and its associated small nucleolar RNAs drive proliferation and migration. Oncogene. 2021;40(5):909–21.

Article  CAS  PubMed  Google Scholar 

Tang G, Zeng Z, Sun W, Li S, You C, Tang F, Peng S, Ma S, Luo Y, Xu J, et al. Small nucleolar RNA 71A promotes Lung Cancer Cell Proliferation, Migration and Invasion via MAPK/ERK Pathway. J Cancer. 2019;10(10):2261–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng D, Zhang J, Ni J, Luo J, Wang J, Tang L, Zhang L, Wang L, Xu J, Su B, et al. Small nucleolar RNA 78 promotes the tumorigenesis in non-small cell lung cancer. J Exp Clin Cancer Res. 2015;34(1):49.

Article  PubMed  PubMed Central  Google Scholar 

Su J, Liao J, Gao L, Shen J, Guarnera MA, Zhan M, Fang H, Stass SA, Jiang F. Analysis of small nucleolar RNAs in sputum for lung cancer diagnosis. Oncotarget. 2016;7(5):5131–42.

Article  PubMed  Google Scholar 

Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science 2020;367(6478).

Wang X, Tian L, Lu J, Ng IO. Exosomes and cancer - diagnostic and prognostic biomarkers and therapeutic vehicle. Oncogenesis. 2022;11(1):54.

Article  PubMed  PubMed Central  Google Scholar 

Rai AK, Rajan KS, Bisserier M, Brojakowska A, Sebastian A, Evans AC, Coleman MA, Mills PJ, Arakelyan A, Uchida S, et al. Spaceflight-Associated Changes of snoRNAs in Peripheral Blood mononuclear cells and plasma Exosomes-A pilot study. Front Cardiovasc Med. 2022;9:886689.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rimer JM, Lee J, Holley CL, Crowder RJ, Chen DL, Hanson PI, Ory DS, Schaffer JE. Long-range function of secreted small nucleolar RNAs that direct 2’-O-methylation. J Biol Chem. 2018;293(34):13284–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang K, Chen J, Li C, Yuan Y, Fang S, Liu W, Qian Y, Ma J, Chang L, Chen F, et al. Exosome-mediated transfer of SNHG7 enhances docetaxel resistance in lung adenocarcinoma. Cancer Lett. 2022;526:142–54.

Article  CAS  PubMed  Google Scholar 

Kitagawa T, Taniuchi K, Tsuboi M, Sakaguchi M, Kohsaki T, Okabayashi T, Saibara T. Circulating pancreatic cancer exosomal RNAs for detection of pancreatic cancer. Mol Oncol. 2019;13(2):212–27.

Article  CAS  PubMed  Google Scholar 

Li S, Qi Y, Huang Y, Guo Y, Huang T, Jia L. Exosome-derived SNHG16 sponging miR-4500 activates HUVEC angiogenesis by targeting GALNT1 via PI3K/Akt/mTOR pathway in hepatocellular carcinoma. J Physiol Biochem. 2021;77(4):667–82.

Article  CAS  PubMed  Google Scholar 

Gong J, Li Y, Liu CJ, Xiang Y, Li C, Ye Y, Zhang Z, Hawke DH, Park PK, Diao L, et al. A pan-cancer analysis of the expression and clinical relevance of small nucleolar RNAs in Human Cancer. Cell Rep. 2017;21(7):1968–81.

Article  CAS  PubMed  Google Scholar 

Murillo OD, Thistlethwaite W, Rozowsky J, Subramanian SL, Lucero R, Shah N, Jackson AR, Srinivasan S, Chung A, Laurent CD, et al. exRNA Atlas Analysis reveals distinct extracellular RNA Cargo types and their carriers present across human biofluids. Cell. 2019;177(2):463–77. e415.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rozowsky J, Kitchen RR, Park JJ, Galeev TR, Diao J, Warrell J, Thistlethwaite W, Subramanian SL, Milosavljevic A, Gerstein M. exceRpt: a Comprehensive Analytic platform for extracellular RNA profiling. Cell Syst. 2019;8(4):352–e357353.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lv CY, Ding WJ, Wang YL, Zhao ZY, Li JH, Chen Y, Lv J. A PEG-based method for the isolation of urinary exosomes and its application in renal fibrosis diagnostics using cargo miR-29c and miR-21 analysis. Int Urol Nephrol. 2018;50(5):973–82.

Article  CAS  PubMed  Google Scholar 

Crossland RE, Norden J, Bibby LA, Davis J, Dickinson AM. Evaluation of optimal extracellular vesicle small RNA isolation and qRT-PCR normalisation for serum and urine. J Immunol Methods. 2016;429:39–49.

Article  CAS  PubMed  Google Scholar 

Wang K, Song X, Wang S, Li X, Zhang Z, Xie L, Song X. Plasma SNORD42B and SNORD111 as potential biomarkers for early diagnosis of non-small cell lung cancer. J Clin Lab Anal. 2022;36(11):e24740.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Crossland RE, Norden J, Bibby L, Davis J, Dickinson AM. Validation of isolation methodology and endogenous control selection for qRT-PCR Assessment of Microrna expression in serum and urine exosomes. Blood 2014;124(21).

Li X, Zhao X, Xie L, Song XG, Song XR. Identification of four snoRNAs (SNORD16, SNORA73B, SCARNA4, and SNORD49B) as novel non-invasive biomarkers for diagnosis of breast cancer. Cancer Cell Int 2024;24(1).

Steinbusch MMF, Fang YX, Milner PI, Clegg PD, Young DA, Welting TJM, Peffers MJ. Serum snoRNAs as biomarkers for joint ageing and post traumatic osteoarthritis. Sci Rep-Uk 2017, 7.

Liao J, Yu L, Mei Y, Guarnera M, Shen J, Li R, Liu Z, Jiang F. Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer. Mol Cancer. 2010;9:198.

Article  PubMed  PubMed Central  Google Scholar 

Peffers MJ, Chabronova A, Balaskas P, Fang YX, Dyer P, Cremers A, Emans PJ, Feczko PZ, Caron MM, Welting TJM. SnoRNA signatures in cartilage ageing and osteoarthritis. Sci Rep-Uk 2020, 10(1).

Redberg RF, O’Malley PG. Important questions about Lung Cancer Screening Programs when Incidental findings Exceed Lung Cancer nodules by 40 to 1. JAMA Intern Med. 2017;177(3):311–2.

Article  PubMed  Google Scholar 

Yang G, Wang T, Qu X, Chen S, Han Z, Chen S, Chen M, Lin J, Yu S, Gao L, et al. Exosomal miR-21/Let-7a ratio distinguishes non-small cell lung cancer from benign pulmonary diseases. Asia Pac J Clin Oncol. 2020;16(4):280–6.

Article  PubMed  PubMed Central  Google Scholar 

Kuang M, Tao X, Peng Y, Zhang W, Pan Y, Cheng L, Yuan C, Zhao Y, Mao H, Zhuge L, et al. Proteomic analysis of plasma exosomes to differentiate malignant from benign pulmonary nodules. Clin Proteom. 2019;16:5.