Bakdash JZ, Marusich LR (2017) Repeated measures correlation. Front Psychol 8:456. https://doi.org/10.3389/fpsyg.2017.00456

Article  PubMed  PubMed Central  Google Scholar 

Banzett RB, Lansing RW, Reid MB et al (1989) “Air hunger” arising from increased PCO2 in mechanically ventilated quadriplegics. Respir Physiol 76:53–67. https://doi.org/10.1016/0034-5687(89)90017-0

Article  CAS  PubMed  Google Scholar 

Banzett RB, Lansing RW, Brown R et al (1990) “Air hunger” from increased PCO2 persists after complete neuromuscular block in humans. Respir Physiol 81:1–17. https://doi.org/10.1016/0034-5687(90)90065-7

Article  CAS  PubMed  Google Scholar 

Banzett RB, Lansing RW, Evans KC, Shea SA (1996) Stimulus-response characteristics of CO2-induced air hunger in normal subjects. Respir Physiol 103:19–31. https://doi.org/10.1016/0034-5687(95)00050-X

Article  CAS  PubMed  Google Scholar 

Banzett RB, Lansing RW, Binks AP (2021) Air hunger: a primal sensation and a primary element of dyspnea. Compr Physiol 11:1449–1483. https://doi.org/10.1002/cphy.c200001

Article  PubMed  PubMed Central  Google Scholar 

Başoğlu M (2017) Effective management of breathlessness: a review of potential human rights issues. Eur Respir J 49:1602099. https://doi.org/10.1183/13993003.02099-2016

Article  PubMed  Google Scholar 

Bureau C, Decavèle M, Campion S et al (2021) Proportional assist ventilation relieves clinically significant dyspnea in critically ill ventilated patients. Ann Intensiv Care 11:177. https://doi.org/10.1186/s13613-021-00958-7

Article  Google Scholar 

Bureau C, Dres M, Morawiec E et al (2022) Dyspnea and the electromyographic activity of inspiratory muscles during weaning from mechanical ventilation. Ann Intensiv Care 12:50. https://doi.org/10.1186/s13613-022-01025-5

Article  Google Scholar 

Campbell ML (2007) Fear and pulmonary stress behaviors to an asphyxial threat across cognitive states. Res Nurs Health 30:572–583. https://doi.org/10.1002/nur.20212

Article  PubMed  Google Scholar 

Dangers L, Montlahuc C, Kouatchet A et al (2018) Dyspnoea in patients receiving noninvasive ventilation for acute respiratory failure: prevalence, risk factors and prognostic impact: a prospective observational study. Eur Respir J 52:1702637. https://doi.org/10.1183/13993003.02637-2017

Article  PubMed  Google Scholar 

Decavèle M, Rivals I, Persichini R et al (2022) Prognostic value of the intensive care respiratory distress observation scale on ICU admission. Respir Care 67:823–832. https://doi.org/10.4187/respcare.09601

Article  PubMed  Google Scholar 

Decavèle M, Bureau C, Campion S et al (2023) Interventions relieving dyspnea in intubated patients show responsiveness of the mechanical ventilation-respiratory distress observation scale. Am J Respir Crit Care Med 208:39–48. https://doi.org/10.1164/rccm.202301-0188OC

Article  PubMed  Google Scholar 

Demoule A, Similowski T (2019) Respiratory suffering in the ICU: time for our next great cause. Am J Respir Crit Care Med 199:1302–1304. https://doi.org/10.1164/rccm.201812-2248ED

Article  PubMed  PubMed Central  Google Scholar 

Demoule A, Hajage D, Messika J et al (2022) Prevalence, intensity and clinical impact of dyspnea in critically ill patients receiving invasive ventilation. Am J Respir Crit Care Med 205(8):917–926

Article  PubMed  Google Scholar 

Demoule A, Baptiste A, Thille AW et al (2024a) Dyspnea is severe and associated with a higher intubation rate in de novo acute hypoxemic respiratory failure. Crit Care Lond Engl 28:174. https://doi.org/10.1186/s13054-024-04903-5

Article  Google Scholar 

Demoule A, Decavele M, Antonelli M et al (2024b) Dyspnoea in acutely ill mechanically ventilated adult patients: an ERS/ESICM statement. Intensiv Care Med 50:159–180. https://doi.org/10.1007/s00134-023-07246-x

Article  Google Scholar 

Demoule A, Decavele M, Antonelli M et al (2024c) Dyspnoea in acutely ill mechanically ventilated adult patients: an ERS/ESICM statement. Eur Respir J 63:2300347. https://doi.org/10.1183/13993003.00347-2023

Article  PubMed  Google Scholar 

Evans KC, Banzett RB, Adams L et al (2002) BOLD fMRI identifies limbic, paralimbic, and cerebellar activation during air hunger. J Neurophysiol 88:1500–1511. https://doi.org/10.1152/jn.2002.88.3.1500

Article  PubMed  Google Scholar 

Haugdahl HS, Storli SL, Meland B et al (2015) Underestimation of patient breathlessness by nurses and physicians during a spontaneous breathing trial. Am J Respir Crit Care Med 192:1440–1448. https://doi.org/10.1164/rccm.201503-0419OC

Article  PubMed  Google Scholar 

Kochovska S, Ferreira D, Chang S et al (2024) Disability and long-term breathlessness: a cross-sectional, population study. BMJ Open Respir Res 11:e002029. https://doi.org/10.1136/bmjresp-2023-002029

Article  PubMed  PubMed Central  Google Scholar 

Kuroda T, Masaoka Y, Kasai H et al (2012) Sharing breathlessness: investigating respiratory change during observation of breath-holding in another. Respir Physiol Neurobiol 180:218–222. https://doi.org/10.1016/j.resp.2011.11.010

Article  PubMed  Google Scholar 

Le Marec J, Hajage D, Decavèle M et al (2024) High airway occlusion pressure is associated with dyspnea and increased mortality in critically Ill mechanically ventilated patients. Am J Respir Crit Care Med 210:201–210. https://doi.org/10.1164/rccm.202308-1358OC

Article  PubMed  Google Scholar 

Lin YC, Lally DA, Moore TO, Hong SK (1974) Physiological and conventional breath-hold breaking points. J Appl Physiol 37:291–296. https://doi.org/10.1152/jappl.1974.37.3.291

Article  CAS  PubMed  Google Scholar 

McKay LC, Adams L, Frackowiak RSJ, Corfield DR (2008) A bilateral cortico-bulbar network associated with breath holding in humans, determined by functional magnetic resonance imaging. Neuroimage 40:1824–1832. https://doi.org/10.1016/j.neuroimage.2008.01.058

Article  PubMed  Google Scholar 

Morélot-Panzini C, Gilet H, Aguilaniu B et al (2016) Real-life assessment of the multidimensional nature of dyspnoea in COPD outpatients. Eur Respir J 47:1668–1679. https://doi.org/10.1183/13993003.01998-2015

Article  PubMed  Google Scholar 

Morélot-Panzini C, Perez T, Sedkaoui K et al (2018) The multidimensional nature of dyspnoea in amyotrophic lateral sclerosis patients with chronic respiratory failure: air hunger, anxiety and fear. Respir Med 145:1–7. https://doi.org/10.1016/j.rmed.2018.10.010

Article  PubMed  Google Scholar 

Nicholas CL, Bei B, Worsnop C et al (2010) Motor unit recruitment in human genioglossus muscle in response to hypercapnia. Sleep 33:1529–1538

Article  PubMed  PubMed Central  Google Scholar 

Niérat M-C, Laviolette L, Hudson A et al (2017) Experimental dyspnea as a stressor: differential cardiovegetative responses to inspiratory threshold loading in healthy men and women. J Appl Physiol Bethesda Md 123:205–212. https://doi.org/10.1152/japplphysiol.00078.2017

Article  CAS  Google Scholar 

Nishino T (2009) Pathophysiology of dyspnea evaluated by breath-holding test: studies of furosemide treatment. Respir Physiol Neurobiol 167:20–25. https://doi.org/10.1016/j.resp.2008.11.007

Article  CAS  PubMed  Google Scholar 

Parshall MB, Schwartzstein RM, Adams L et al (2012) An official American thoracic society statement: update on the mechanisms, assessment, and management of dyspnea. Am J Respir Crit Care Med 185:435–452. https://doi.org/10.1164/rccm.201111-2042ST

Article  PubMed  PubMed Central  Google Scholar 

Pierre D (1965) Hazard of hypoxia during diving. In: Rahn H, Yokoyama T (eds) Physiology of breath-hold diving and the ama of Japan. National Academy of Science National Research Council

Google Scholar 

Raji RK, Miao X, Wan A et al (2019) Knitted piezoresistive smart chest band and its application for respiration patterns assessment. J Eng Fibers Fabr 14:1558925019868474. https://doi.org/10.1177/1558925019868474

Article  Google Scholar 

Ries AL (2006) Impact of chronic obstructive pulmonary disease on quality of life: the role of dyspnea. Am J Med 119:12–20.