Biniecka M, Connolly M, Gao W, Ng CT, Balogh E, Gogarty M, Santos L, Murphy E, Brayden D, Veale DJ, Fearon U. Redox-mediated angiogenesis in the hypoxic joint of inflammatory arthritis. Arthritis Rheumatol. 2014;66:3300–10. https://doi.org/10.1002/art.38822.
Article CAS PubMed Google Scholar
Binymin K, Herrick A, Carlson G, Hopkins S. The effect of disease activity on body composition and resting energy expenditure in patients with rheumatoid arthritis. J Inflamm Res. 2011;4:61–6. https://doi.org/10.2147/JIR.S16508.
Article CAS PubMed PubMed Central Google Scholar
Boreddy SR, Sahu RP, Srivastava SK. Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-α/VEGF/Rho-GTPases: pivotal role of STAT-3. PLoS ONE. 2011;6:e25799. https://doi.org/10.1371/journal.pone.0025799.
Article CAS PubMed PubMed Central Google Scholar
Choi KM, Kim JJ, Yoo J, Kim KS, Gu Y, Eom J, Jeong H, Kim K, Nam KT, Park YS, Chung J-Y, Seo J-Y. The interferon-inducible protein viperin controls cancer metabolic reprogramming to enhance cancer progression. J Clin Invest. 2022;132:e157302. https://doi.org/10.1172/JCI157302.
Article CAS PubMed PubMed Central Google Scholar
Courtnay R, Ngo DC, Malik N, Ververis K, Tortorella SM, Karagiannis TC. Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K. Mol Biol Rep. 2015;42:841–51. https://doi.org/10.1007/s11033-015-3858-x.
Article CAS PubMed Google Scholar
El-Said KS, Atta A, Mobasher MA, Germoush MO, Mohamed TM, Salem MM. Quercetin mitigates rheumatoid arthritis by inhibiting adenosine deaminase in rats. Mol Med. 2022;28(1):24. https://doi.org/10.1186/s10020-022-00432-5.
Article CAS PubMed PubMed Central Google Scholar
Falconer J, Murphy AN, Young SP, Clark AR, Tiziani S, Guma M, Buckley CD. Review: synovial cell metabolism and chronic inflammation in rheumatoid arthritis. Arthritis Rheumatol. 2018;70:984–99. https://doi.org/10.1002/art.40504.
Article CAS PubMed PubMed Central Google Scholar
Fearon U, Canavan M, Biniecka M, Veale DJ. Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis. Nat Rev Rheumatol. 2016;12:385–97. https://doi.org/10.1038/nrrheum.2016.69.
Article CAS PubMed Google Scholar
Fearon U, Hanlon MM, Floudas A, Veale DJ. Cellular metabolic adaptations in rheumatoid arthritis and their therapeutic implications. Nat Rev Rheumatol. 2022;18:398–414. https://doi.org/10.1038/s41584-022-00771-x.
Article CAS PubMed Google Scholar
Friščić J, Böttcher M, Reinwald C, Bruns H, Wirth B, Popp S-J, Walker KI, Ackermann JA, Chen X, Turner J, Zhu H, Seyler L, Euler M, Kirchner P, Krüger R, Ekici AB, Major T, Aust O, Weidner D, Fischer A, Andes FT, Stanojevic Z, Trajkovic V, Herrmann M, Korb-Pap A, Wank I, Hess A, Winter J, Wixler V, Distler J, Steiner G, Kiener HP, Frey B, Kling L, Raza K, Frey S, Kleyer A, Bäuerle T, Hughes TR, Grüneboom A, Steffen U, Krönke G, Croft AP, Filer A, Köhl J, Klein K, Buckley CD, Schett G, Mougiakakos D, Hoffmann MH. The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts. Immunity. 2021;54:1002–21.e10.
Gaber T, Dziurla R, Tripmacher R, Burmester GR, Buttgereit F. Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do! Ann Rheum Dis. 2005;64:971–80. https://doi.org/10.1136/ard.2004.031641.
Article CAS PubMed PubMed Central Google Scholar
Ganapathy-Kanniappan S, Geschwind J-FH. Tumor glycolysis as a target for cancer therapy: progress and prospects. Mol Cancer. 2013;12:152. https://doi.org/10.1186/1476-4598-12-152.
Article CAS PubMed PubMed Central Google Scholar
Gao W, McCormick J, Connolly M, Balogh E, Veale DJ, Fearon U. Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis. Ann Rheum Dis. 2015;74:1275–83. https://doi.org/10.1136/annrheumdis-2013-204105.
Article CAS PubMed Google Scholar
Garcia-Carbonell R, Divakaruni AS, Lodi A, Vicente-Suarez I, Saha A, Cheroutre H, et al. Critical role of glucose metabolism in rheumatoid arthritis fibroblast-like synoviocytes. Arthritis Rheumatol. 2016;68(7):1614–26. https://doi.org/10.1002/art.39608.
Article CAS PubMed PubMed Central Google Scholar
Gardi C, Bauerova K, Stringa B, Kuncirova V, Slovak L, Ponist S, Drafi F, Bezakova L, Tedesco I, Acquaviva A, Bilotto S, Russo GL. Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis. Arch Biochem Biophys. 2015;583:150–7. https://doi.org/10.1016/j.abb.2015.08.008.
Article CAS PubMed Google Scholar
Guo B, Chou F, Huang L, Yin F, Fang J, Wang J-B, Jia Z. Recent insights into oxidative metabolism of quercetin: catabolic profiles, degradation pathways, catalyzing metalloenzymes and molecular mechanisms. Crit Rev Food Sci Nutr. 2024;64:1312–39. https://doi.org/10.1080/10408398.2022.2115456.
Article CAS PubMed Google Scholar
Haleagrahara N, Miranda-Hernandez S, Alim MA, Hayes L, Bird G, Ketheesan N. Therapeutic effect of quercetin in collagen-induced arthritis. Biomed Pharmacother. 2017;90:38–46. https://doi.org/10.1016/j.biopha.2017.03.026.
Article CAS PubMed Google Scholar
Hua S, Dias TH. Hypoxia-inducible factor (HIF) as a target for Novel therapies in Rheumatoid Arthritis. Front Pharmacol. 2016;7:184. https://doi.org/10.3389/fphar.2016.00184.
Article CAS PubMed PubMed Central Google Scholar
Jia N, Gao Y, Li M, Liang Y, Li Y, Lin Y, Huang S, Lin Q, Sun X, He Q, Yao Y, Zhang B, Zhang Z, Zhang L. Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms. Signal Transduct Target Ther. 2023;8:280. https://doi.org/10.1038/s41392-023-01499-0.
Article CAS PubMed PubMed Central Google Scholar
King KL, Cidlowski JA. Cell cycle regulation and apoptosis. Annu Rev Physiol. 1998;60:601–17. https://doi.org/10.1146/annurev.physiol.60.1.601.
Article CAS PubMed Google Scholar
Koedderitzsch K, Zezina E, Li L, Herrmann M, Biesemann N. TNF induces glycolytic shift in fibroblast like synoviocytes via GLUT1 and HIF1A. Sci Rep. 2021;11:19385. https://doi.org/10.1038/s41598-021-98651-z.
Article CAS PubMed PubMed Central Google Scholar
Kugler M, Dellinger M, Kartnig F, Müller L, Preglej T, Heinz LX, Simader E, Göschl L, Puchner SE, Weiss S, Shaw LE, Farlik M, Weninger W, Superti-Furga G, Smolen JS, Steiner G, Aletaha D, Kiener HP, Lewis MJ, Pitzalis C, Tosevska A, Karonitsch T, Bonelli M. Cytokine-directed cellular cross-talk imprints synovial pathotypes in rheumatoid arthritis. Ann Rheum Dis. 2023;82:1142–52. https://doi.org/10.1136/ard-2022-223396.
Article CAS PubMed Google Scholar
Lee S, Choi E, Chae S, Koh JH, Choi Y, Kim JG, Yoo S-A, Hwang D, Kim W-U. Identification of MYH9 as a key regulator for synoviocyte migration and invasion through secretome profiling. Ann Rheum Dis. 2023;82:1035–48. https://doi.org/10.1136/ard-2022-223625.
Article CAS PubMed Google Scholar
Li X, Liu, Yongzhuang, Yu Y, Chen W, Liu, Yixing, Yu H. Nanoformulations of quercetin and cellulose nanofibers as healthcare supplements with sustained antioxidant activity. Carbohydr Polym. 2019;207:160–8. https://doi.org/10.1016/j.carbpol.2018.11.084.
Article CAS PubMed Google Scholar
Liu B, Xian Y, Chen X, Shi Y, Dong J, Yang L, et al. Inflammatory fibroblast-like synoviocyte-derived exosomes aggravate osteoarthritis via enhancing macrophage glycolysis. Adv Sci (Weinh). 2024;11:e2307338. https://doi.org/10.1002/advs.202307338.
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