Brown A, Kumar S, Tchounwou PB. Cisplatin-based chemotherapy of human cancers. J Cancer Sci Ther. 2019;11(4):97.

PubMed  PubMed Central  Google Scholar 

Han Y, Wen P, Li J, Kataoka K. Targeted nanomedicine in cisplatin-based cancer therapeutics. J Controlled Release. 2022;345:709–20.

Article  CAS  Google Scholar 

Einhorn LH. Treatment of testicular cancer: a new and improved model. J Clin Oncol. 1990;8(11):1777–81.

Article  CAS  PubMed  Google Scholar 

Rajput K, Edwards L, Brock P, Abiodun A, Simpkin P, Al-Malky G. Ototoxicity-induced hearing loss and quality of life in survivors of paediatric cancer. Int J Pediatr Otorhinolaryngol. 2020;138:110401.

Article  PubMed  Google Scholar 

Chattaraj A, Syed MP, Low CA, Owonikoko TK. Cisplatin-induced ototoxicity. A concise review of the b, prevention, and interception strategies. JCO Oncol Pract. 2023;19(5):278–83.

Sheth S, Mukherjea D, Rybak LP, Ramkumar V. Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection. Front Cell Neurosci. 2017;11:338.

Article  PubMed  PubMed Central  Google Scholar 

Karasawa T, Steyger PS. An integrated view of cisplatin-induced nephrotoxicity and ototoxicity. Toxicol Lett. 2015;237(3):219–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marullo R, Werner E, Degtyareva N, Moore B, Altavilla G, Ramalingam SS, et al. Cisplatin induces a Mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions. PLoS ONE. 2013;8(11):e81162.

Article  PubMed  PubMed Central  Google Scholar 

Devarajan P, Savoca M, Castaneda MP, Park MS, Esteban-Cruciani N, Kalinec G, et al. Cisplatin-induced apoptosis in auditory cells: role of death receptor and mitochondrial pathways. Hear Res. 2002;174(1):45–54.

Article  CAS  PubMed  Google Scholar 

Mukherjea D, Whitworth CA, Nandish S, Dunaway GA, Rybak LP, Ramkumar V. Expression of the kidney injury molecule 1 in the rat cochlea and induction by cisplatin. Neuroscience. 2006;139(2):733–40.

Article  CAS  PubMed  Google Scholar 

Lynch ED, Gu R, Pierce C, Kil J. Reduction of acute cisplatin ototoxicity and nephrotoxicity in rats by oral administration of allopurinol and ebselen. Hear Res. 2005;201(1):81–9.

Article  CAS  PubMed  Google Scholar 

Ramkumar V, Mukherjea D, Dhukhwa A, Rybak LP. Oxidative stress and inflammation caused by Cisplatin Ototoxicity. Antioxidants. 2021;10(12):1919.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Womer RB, Silber JH. Predicting cisplatin ototoxicity in children: the influence of age and the cumulative dose. Eur J Cancer. 2004;40(16):2445–51.

Tan WJT, Vlajkovic SM. Molecular characteristics of Cisplatin-Induced ototoxicity and therapeutic interventions. Int J Mol Sci. 2023;24(22):16545.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meijer AJM, Diepstraten FA, van den Heuvel-Eibrink MM, Bleyer A. Prevention of cisplatin-induced hearing loss in children: achievements and challenges for evidence-based implementation of sodium thiosulfate. Front Oncol. 2024;14:1336714.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chopra D, Rehan HS, Sharma V, Mishra R. Chemotherapy-induced adverse drug reactions in oncology patients: a prospective observational survey. Indian J Med Paediatr Oncol off J Indian Soc Med Paediatr Oncol. 2016;37(1):42–6.

Article  Google Scholar 

Xu H, Robinson GW, Huang J, Lim JYS, Zhang H, Bass JK, et al. Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss. Nat Genet. 2015;47(3):263–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dille MF, Wilmington D, McMillan GP, Helt W, Fausti SA, Konrad-Martin D. Development and validation of a cisplatin dose-ototoxicity model. J Am Acad Audiol. 2012;23(7):510–21.

Article  PubMed  PubMed Central  Google Scholar 

Deutsch BC, Collopy C, Kallogjeri D, Piccirillo JF. Validation of hearing loss Prediction Tool for Cisplatin Chemotherapy and Radiation in Head and Neck Cancer Treatment. JAMA Otolaryngol Neck Surg. 2021;147(2):182–9.

Article  Google Scholar 

Dolan ME, Newbold KG, Nagasubramanian R, Wu X, Ratain MJ, Cook EH, et al. Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity. Cancer Res. 2004;64(12):4353–6.

Article  CAS  PubMed  Google Scholar 

Thiesen S, Yin P, Jorgensen AL, Zhang JE, Manzo V, McEvoy L, et al. TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity. Pharmacogenet Genomics. 2017;27(6):213–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Drögemöller BI, Brooks B, Critchley C, Monzon JG, Wright GEB, Liu G, et al. Further investigation of the role of ACYP2 and WFS1 pharmacogenomic variants in the Development of Cisplatin-Induced Ototoxicity in Testicular Cancer patients. Clin Cancer Res. 2018;24(8):1866–71.

Article  PubMed  Google Scholar 

Drögemöller BI, Wright GEB, Lo C, Le T, Brooks B, Bhavsar AP, et al. Pharmacogenomics of Cisplatin-Induced Ototoxicity: successes, shortcomings, and future avenues of Research. Clin Pharmacol Ther. 2019;106(2):350–9.

Article  PubMed  Google Scholar 

Wilke M. Using genomics to guide the development of strategies to predict and prevent cisplatin-induced ototoxicity. 2022 Dec 29 [cited 2023 Nov 15]; http://hdl.handle.net/1993/37057

Kalra G, Milon B, Casella AM, Herb BR, Humphries E, Song Y, et al. Biological insights from multi-omic analysis of 31 genomic risk loci for adult hearing difficulty. PLoS Genet. 2020;16(9):e1009025.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wheeler HE, Gamazon ER, Frisina RD, Perez-Cervantes C, El Charif O, Mapes B, et al. Variants in WFS1 and other mendelian deafness genes are Associated with Cisplatin-Associated Ototoxicity. Clin Cancer Res off J Am Assoc Cancer Res. 2017;23(13):3325–33.

Article  CAS  Google Scholar 

Meijer AJM, Diepstraten FA, Langer T, Broer L, Domingo IK, Clemens E, et al. TCERG1L allelic variation is associated with cisplatin-induced hearing loss in childhood cancer, a PanCareLIFE study. NPJ Precis Oncol. 2021;5(1):64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Breglio AM, Rusheen AE, Shide ED, Fernandez KA, Spielbauer KK, McLachlin KM, et al. Cisplatin is retained in the cochlea indefinitely following chemotherapy. Nat Commun. 2017;8(1):1654.

Article  PubMed  PubMed Central  Google Scholar 

Yimit A, Adebali O, Sancar A, Jiang Y. Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs. Nat Commun. 2019;10(1):309.

Article  PubMed  PubMed Central  Google Scholar 

Noda T, Meas SJ, Nogami J, Amemiya Y, Uchi R, Ohkawa Y, et al. Direct reprogramming of spiral ganglion non-neuronal cells into neurons: toward ameliorating Sensorineural hearing loss by Gene Therapy. Front Cell Dev Biol. 2018;6:16.

Article  PubMed  PubMed Central  Google Scholar 

Jean P, Wong Jun Tai F, Singh-Estivalet A, Lelli A, Scandola C, Megharba S et al. Single-cell transcriptomic profiling of the mouse cochlea: an atlas for targeted therapies. Proc Natl Acad Sci U S A 120(26):e2221744120.

GitHub - hakyimlab. /summary-gwas-imputation: harmonization, liftover, and imputation of summary statistics from GWAS [Internet]. [cited 2024 Mar 11]. https://github.com/hakyimlab/summary-gwas-imputation

Lloyd-Jones LR, Zeng J, Sidorenko J, Yengo L, Moser G, Kemper KE, et al. Improved polygenic prediction by bayesian multiple regression on summary statistics. Nat Commun. 2019;10:5086.

Article  PubMed  PubMed Central  Google Scholar 

Dann E, Henderson NC, Teichmann SA, Morgan MD, Marioni JC. Differential abundance testing on single-cell data using k-nearest neighbor graphs. Nat Biotechnol. 2022;40(2):245–53.

Article  CAS  PubMed  Google Scholar 

Love MI, Huber W, Anders S. Moderated estimation of Fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550.

Article