[1] Rodriguez-Wallberg KA, Jiang Y, Lekberg T, Nilsson HP. The late effects of cancer treatment on female fertility and the current status of fertility preservation-a narrative review. Life 2023; 13: 1195.

[2] Alesi LR, Nguyen Q-N, Stringer JM, Winship AL, Hutt KJ. The future of fertility preservation for women treated with chemotherapy. Reprod Fertil 2023; 4: e220123.

[3] Feng J, Ma W-W, Li H-X, Pei X-Y, Deng S-L, Jia H, et al. Melatonin prevents cyclophosphamide-induced primordial follicle loss by inhibiting ovarian granulosa cell apoptosis and maintaining AMH expression. Front Endocrinol (Lausanne) 2022; 13: 895095.

[4] Raeeszadeh M, Hosseini SMS, Amiri AA. Impact of co-administration of N-acetylcysteine and vitamin E on cyclophosphamide-induced ovarian toxicity in female rats. J Toxicol 2022; 2022: 9073405.

[5] Spears N, Lopes F, Stefansdottir A, Rossi V, De Felici M, Anderson RA, et al. Ovarian damage from chemotherapy and current approaches to its protection. Hum Reprod Update 2019; 25: 673–693.

[6] Yang W, Ma Y, Jin J, Ren P, Zhou H, Xu S, et al. Cyclophosphamide exposure causes long-term detrimental effect of oocytes developmental competence through affecting the epigenetic modification and maternal factors’ transcription during oocyte growth. Front Cell Dev Biol 2021; 9: 682060.

[7] Rakha SI, Elmetwally MA, El-Sheikh Ali H, Balboula A, Mahmoud AM, Zaabel SM. Importance of antioxidant supplementation during in vitro maturation of mammalian oocytes. Vet Sci 2022; 9: 439.

[8] Yang L, Chen Y, Liu Y, Xing Y, Miao C, Zhao Y, et al. The role of oxidative stress and natural antioxidants in ovarian aging. Front Pharmacol 2021; 11: 617843.

[9] Jiang W, Li Y, Zhao Y, Gao Q, Jin Q, Yan C, et al. L-carnitine supplementation during in vitro culture regulates oxidative stress in embryos from bovine aged oocytes. Theriogenology 2020; 143: 64–73.

[10] Behi Shahreza P, Ahmadpour S, Almasi M, Seyyed Hosseini E, Akhavan Taheri M, Moshkdanian Gh. The effect of L-carnitine on oocyte mitochondrial health and biomarkers on cyclophosphamide chemotherapy drug in mice. Reprod Toxicol 2023; 122: 108490.

[11] Li X, Wu X, Ma T, Zhang Y, Sun P, Qi D, et al. Protective effect of L-carnitine against oxidative stress injury in human ovarian granulosa cells. Exp Ther Med 2023; 25: 161.

[12] Li J, Liu L, Weng J, Yin T-L, Yang J, Feng HL. Biological roles of L-carnitine in oocyte and early embryo development. Mol Reprod Dev 2021; 88: 673–685.

[13] Sanamiri Kh, Soleimani Mehranjani M, Shahhoseini M, Shariatzadeh MA. L-carnitine improves follicular survival and function in ovarian grafts in the mouse. Reprod Fertil Dev 2022; 34: 713–721.

[14] Rajab AA, Hafidh A, Al-Shmgani HS. The impact of platelet-rich plasma and L-carnitine on cyclophosphamide-induced hematotoxicity in male albino rats. Biochem Cell Arch 2022; 22: 85.

[15] Shafiei G, Moghani-Ghoroghi F, Miyan J, Almasi M, Regerdi Kashani I, Nikzad H, et al. Melatonin protects against visible light-induced oxidative stress and promotes the implantation potential of mouse blastocyst in vitro. Res Vet Sci 2023; 155: 29–35.

[16] El Kiki SM, Omran MM, Mansour HH, Hasan HF. Metformin and/or low dose radiation reduces cardiotoxicity and apoptosis induced by cyclophosphamide through SIRT-1/SOD and BAX/Bcl-2 pathways in rats. Mol Biol Rep 2020; 47: 5115–5126.

[17] Zhang B-F, Hu Y, Liu X, Cheng Z, Lei Y, Liu Y, et al. The role of AKT and FOXO3 in preventing ovarian toxicity induced by cyclophosphamide. PloS One 2018; 13: e0201136.

[18] Barberino RS, Silva RLS, Palheta Junior RC, Smitz JEJ, Matos MHT. Protective effects of antioxidants on cyclophosphamide-induced ovarian toxicity. Biopreserv Biobank 2023; 21: 121–141.

[19] Liu W, Chen Q, Liu Z, Weng Z, Nguyen TN, Feng J, et al. Zihuai recipe alleviates cyclophosphamide-induced diminished ovarian reserve via suppressing PI3K/AKT-mediated apoptosis. J Ethnopharmacol 2021; 277: 113789.

[20] Chen Y, Zhao Y, Miao C, Yang L, Wang R, Chen B, et al. Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells. J Ovarian Res 2022; 15: 138.

[21] Aladaileh SH, Abukhalil MH, Saghir SAM, Hanieh H, Alfwuaires MA, Almaiman AA, et al. Galangin activates Nrf2 signaling and attenuates oxidative damage, inflammation, and apoptosis in a rat model of cyclophosphamide-induced hepatotoxicity. Biomolecules 2019; 9: 346.

[22] Wang W, Zhang D, Sun L, Zhang Z, Zhang Y, Zhang Y, et al. Alpha-lipoic acid supplementation reverses the declining quality of oocytes exposed to cyclophosphamide. Food Chem Toxicol 2023; 181: 114090.

[23] Zhang S, Liu Q, Chang M, Pan Y, Yahaya BH, Liu Y, et al. Chemotherapy impairs ovarian function through excessive ROS-induced ferroptosis. Cell Death Dis 2023; 14: 340.

[24] Wang L, Tang J, Wang L, Tan F, Song H, Zhou J, et al. Oxidative stress in oocyte aging and female reproduction. J Cell Physiol 2021; 236: 7966–7983.

[25] Hussain T. Antioxidant strategies to improve female reproduction. In: Otero Fuertes P, Fraga Corralga Corral M. Recent developments in antioxidants from natural sources. IntechOpen; 2023. Available at: www.intechopen.com/chapters/86532.

[26] Shafiei G, Almasi M, Nikzad H, Miyan J, Amini Mahabadi J, Moshkdanian Gh. L-carnitine reduces the adverse effects of ROS and up-regulates the expression of implantation related genes in in vitro developed mouse embryos. Theriogenology 2020; 145: 59–66.

[27] Lee Y-CG, Chou H-C, Chen Y-T, Tung S-Y, Ko T-L, Buyandelger B, et al. L-carnitine reduces reactive oxygen species/endoplasmic reticulum stress and maintains mitochondrial function during autophagy-mediated cell apoptosis in perfluorooctanesulfonate-treated renal tubular cells. Sci Rep 2022; 12: 4673.

[28] Morid OF, Menze ET, Tadros MG, George MY. L-Carnitine modulates cognitive impairment induced by doxorubicin and cyclophosphamide in rats; insights to oxidative stress, inflammation, synaptic plasticity, liver/brain, and kidney/brain axes. J Neuroimmune Pharmacol 2023; 18: 310–326.

[29] Bushra RR, Bastwrous AE. Possible protective role of L-carnitine against cisplatin-induced testicular changes in adult male albino rats: A histological and morphometric study. Egypt Acad J Biol Sci, D Histol Histochem 2022; 14: 81–94.

[30] Alkasaby Zalat Z, Abdel-Latif MM, Alotaibi BS, Alm El-Din MA, Kohaf NA, Elewa HA. Efficacy of L-carnitine and silymarin administration on the health-related quality of life in 120 patients with cancer undergoing anthracycline-based chemotherapy. J Med Life Sci 2020; 2: 20–38.

[31] Momenzadeh M, Aria A, Ghadimi K, Moghaddas A. Acetyl-L-carnitine for the prevention of taxane-induced neuropathy in patients with breast cancer: A systematic review and meta-analysis. Res Pharm Sci 2023; 18: 112–120.

[32] Zhang Q, Wang S-M, Yao P-B, Zhang L, Zhang Y-J, Chen R-X, et al. Effects of L-carnitine on follicular survival and graft function following autotransplantation of cryopreserved-thawed ovarian tissues. Cryobiology 2015; 71: 135–140.

[33] El-Sokary MMM, El-Naby Al-HH, Abd El Hameed AR, Mahmoud KGM, Scholkamy TH. Impact of L-carnitine supplementation on the in vitro developmental competence and cryotolerance of buffalo embryos. Vet World 2021; 14: 3164–3169.

[34] Placidi M, Di Emidio G, Virmani A, D’Alfonso A, Artini PG, D’Alessandro AM, et al. Carnitines as mitochondrial modulators of oocyte and embryo bioenergetics. Antioxidants 2022; 11: 745.

[35] Silva BR, Silva JRV. Mechanisms of action of non-enzymatic antioxidants to control oxidative stress during in vitro follicle growth, oocyte maturation, and embryo development. Anim Reprod Sci 2023; 249: 107186.

[36] Khedr NF, Werida RH. L-carnitine modulates autophagy, oxidative stress and inflammation in trazodone induced testicular toxicity. Life Sci 2022; 290: 120025.

[37] Salama A, Elgohary R. L-carnitine and Co Q10 ameliorate potassium dichromate-induced acute brain injury in rats targeting AMPK/AKT/NF-?ß. Int Immunopharmacol 2021; 101: 107867.

[38] Farag A, Elfadadny A, Mandour AS, Ngeun SK, Aboubakr M, Kaneda M, et al. Potential protective effects of L-carnitine against myocardial ischemia/reperfusion injury in a rat model. Environ Sci Pollut Res Int 2024; 31: 18813–18825.

[39] Giorgi VSI, Da Broi MG, Paz CCP, Ferriani RA, Navarro PA. N-acetyl-cysteine and L-carnitine prevent meiotic oocyte damage induced by follicular fluid from infertile women with mild endometriosis. Reprod Sci 2016; 23: 342–351.

[40] Vardiyan R, Ezati D, Anvari M, Ghasemi N, Talebi A. Effect of L-carnitine on the expression of the apoptotic genes Bcl-2 and Bax. Clin Exp Reprod Med 2020; 47: 155–160.

[41] Mishra A, Reddy IJ, Gupta P, Mondal S. Developmental regulation and modulation of apoptotic genes expression in sheep oocytes and embryos cultured in vitro with L-carnitine. Reprod Domest Anim 2016; 51: 1020–1029.

[42] Hassan N, Rashad M, Elleithy E, Sabry Z, Ali G, Elmosalamy S. L-carnitine alleviates hepatic and renal mitochondrial-dependent apoptotic progression induced by letrozole in female rats through modulation of Nrf-2, Cyt c and CASP-3 signaling. Drug Chem Toxicol 2023; 46: 357–368.

[43] Li P, Xia Z, Kong W, Wang Q, Zhao Z, Arnold A, et al. Exogenous L-carnitine ameliorates burn-induced cellular and mitochondrial injury of hepatocytes by restoring CPT1 activity. Nutr Metab 2021; 18: 65.