Condic, M. L. Totipotency: what it is and what it is not. Stem Cell Dev. 23, 796–812 (2014).
Gurdon, J. B., Elsdale, T. R. & Fischberg, M. Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei. Nature 182, 64–65 (1958).
Article CAS PubMed Google Scholar
Gurdon, J. B. & Uehlinger, V. Fertile’ intestine nuclei. Nature 210, 1240–1241 (1966).
Article CAS PubMed Google Scholar
Nakao, S. et al. Synchronization of the ovulation and copulation timings increased the number of in vivo fertilized oocytes in superovulated female mice. PLoS ONE 18, e0281330 (2023).
Article CAS PubMed PubMed Central Google Scholar
Yu, J. & Thomson, J. A. in Principles of Tissue Engineering (eds Lanza, R. et al.) 581–594 (Elsevier, 2014).
Takahashi, K. & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663–676 (2006).
Article CAS PubMed Google Scholar
Sha, Q.-Q. et al. Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans. Nat. Commun. 11, 4917 (2020).
Article CAS PubMed PubMed Central Google Scholar
Eckersley-Maslin, M. A., Alda-Catalinas, C. & Reik, W. Dynamics of the epigenetic landscape during the maternal-to-zygotic transition. Nat. Rev. Mol. Cell Biol. 19, 436–450 (2018).
Article CAS PubMed Google Scholar
Ladstätter, S. & Tachibana, K. Genomic insights into chromatin reprogramming to totipotency in embryos. J. Cell Biol. 218, 70–82 (2019).
Article PubMed PubMed Central Google Scholar
Grow, E. J. et al. Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells. Nature 522, 221–225 (2015).
Article CAS PubMed PubMed Central Google Scholar
Greenberg, M. V. C. & Bourc’his, D. The diverse roles of DNA methylation in mammalian development and disease. Nat. Rev. Mol. Cell Biol. 20, 590–607 (2019).
Article CAS PubMed Google Scholar
Smith, Z. D. & Meissner, A. DNA methylation: roles in mammalian development. Nat. Rev. Genet. 14, 204–220 (2013).
Article CAS PubMed Google Scholar
Rowe, H. M. & Trono, D. Dynamic control of endogenous retroviruses during development. Virology 411, 273–287 (2011).
Article CAS PubMed Google Scholar
Chernyavskaya, Y. et al. Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling. Development 144, 2925–2939 (2017).
Article CAS PubMed PubMed Central Google Scholar
Gkountela, S. et al. DNA demethylation dynamics in the human prenatal germline. Cell 161, 1425–1436 (2015).
Article CAS PubMed PubMed Central Google Scholar
Fueyo, R., Judd, J., Feschotte, C. & Wysocka, J. Roles of transposable elements in the regulation of mammalian transcription. Nat. Rev. Mol. Cell Biol. 23, 481–497 (2022).
Article CAS PubMed PubMed Central Google Scholar
Jachowicz, J. W. et al. LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo. Nat. Genet. 49, 1502–1510 (2017).
Article CAS PubMed Google Scholar
Percharde, M. et al. A LINE1–nucleolin partnership regulates early development and ESC identity. Cell 174, 391–405.e19 (2018).
Article CAS PubMed PubMed Central Google Scholar
Sakashita, A. et al. Transcription of MERVL retrotransposons is required for preimplantation embryo development. Nat. Genet. 55, 484–495 (2023).
Article CAS PubMed PubMed Central Google Scholar
Zhang, W. et al. Zscan4c activates endogenous retrovirus MERVL and cleavage embryo genes. Nucleic Acids Res. 47, 8485–8501 (2019).
CAS PubMed PubMed Central Google Scholar
Lu, J. Y. et al. Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome. Cell Res. 31, 613–630 (2021).
Article CAS PubMed PubMed Central Google Scholar
Yang, J., Cook, L. & Chen, Z. Systematic evaluation of retroviral LTRs as cis-regulatory elements in mouse embryos. Cell Rep. 43, 113775 (2024).
Article CAS PubMed PubMed Central Google Scholar
Mouse Genome Sequencing Consortium et al. Initial sequencing and comparative analysis of the mouse genome. Nature 420, 520–562 (2002).
Ge, S. X. Exploratory bioinformatics investigation reveals importance of ‘junk’ DNA in early embryo development. BMC Genomics 18, 200 (2017).
Article PubMed PubMed Central Google Scholar
Modzelewski, A. J. et al. A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development. Cell 184, 5541–5558.e22 (2021).
Article CAS PubMed PubMed Central Google Scholar
Schulz, K. N. & Harrison, M. M. Mechanisms regulating zygotic genome activation. Nat. Rev. Genet. 20, 221–234 (2019).
Article CAS PubMed PubMed Central Google Scholar
Murphy, P. J., Wu, S. F., James, C. R., Wike, C. L. & Cairns, B. R. Placeholder nucleosomes underlie germline-to-embryo DNA methylation reprogramming. Cell 172, 993–1006.e13 (2018).
Article CAS PubMed Google Scholar
Gassler, J. et al. Zygotic genome activation by the totipotency pioneer factor Nr5a2. Science 378, 1305–1315 (2022).
Article CAS PubMed Google Scholar
Kobayashi, W. et al. Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition. Nat. Struct. Mol. Biol. 31, 757–766 (2024).
Article CAS PubMed PubMed Central Google Scholar
Zou, Z. et al. Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation. Science 378, eabo7923 (2022).
Ji, S. et al. OBOX regulates mouse zygotic genome activation and early development. Nature 620, 1047–1053 (2023).
Article CAS PubMed PubMed Central Google Scholar
Wu, E. & Vastenhouw, N. L. From mother to embryo: a molecular perspective on zygotic genome activation. Curr. Top. Dev. Biol. 140, 209–254 (2020).
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