Gehart, H. & Clevers, H. Tales from the crypt: new insights into intestinal stem cells. Nat. Rev. Gastroenterol. Hepatol. 16, 19–34 (2019).

Article  PubMed  Google Scholar 

Lien, E. C. & Vander Heiden, M. G. A framework for examining how diet impacts tumour metabolism. Nat. Rev. Cancer 19, 651–661 (2019).

Article  CAS  PubMed  Google Scholar 

Yilmaz, Ö. H. Dietary regulation of the origins of cancer. Sci. Transl. Med. 10, 8–11 (2018).

Article  Google Scholar 

Cheng, C.-W. & Yilmaz, Ö. H. 100 years of exploiting diet and nutrition for tissue regeneration. Cell Stem Cell 28, 370–373 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

The GBD 2015 Obesity Collaborators. Health effects of overweight and obesity in 195 countries over 25 years. N. Engl. J. Med. 377, 13–27 (2017).

Article  Google Scholar 

Ng, M. et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384, 766–781 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Mehta, R. S. et al. Dietary patterns and risk of colorectal cancer: analysis by tumor location and molecular subtypes. Gastroenterology 152, 1944–1953.e1 (2017).

Article  CAS  PubMed  Google Scholar 

Zaborowski, A. M. et al. Characteristics of early-onset vs late-onset colorectal cancer. JAMA Surg. 156, 865 (2021).

Article  PubMed  Google Scholar 

Haber, A. L. et al. A single-cell survey of the small intestinal epithelium. Nature 551, 333–339 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gehart, H. et al. Identification of enteroendocrine regulators by real-time single-cell differentiation mapping. Cell 176, 1158–1173.e16 (2019).

Article  CAS  PubMed  Google Scholar 

Barker, N. et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449, 1003–1007 (2007).

Article  CAS  PubMed  Google Scholar 

Sato, T. et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262–265 (2009).

Article  CAS  PubMed  Google Scholar 

Snippert, H. J. et al. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell 143, 134–144 (2010).

Article  CAS  PubMed  Google Scholar 

Yui, S. et al. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell. Nat. Med. 18, 618–623 (2012).

Article  CAS  PubMed  Google Scholar 

Takeda, N. et al. Interconversion between intestinal stem cell populations in distinct niches. Science 334, 1420–1424 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wong, V. W. Y. et al. Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat. Cell Biol. 14, 401–408 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan, K. S. et al. The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. Proc. Natl Acad. Sci. USA 109, 466–471 (2012).

Article  CAS  PubMed  Google Scholar 

Li, N., Nakauka-Ddamba, A., Tobias, J., Jensen, S. T. & Lengner, C. J. Mouse label-retaining cells are molecularly and functionally distinct from reserve intestinal stem cells. Gastroenterology 151, 298–310.e7 (2016).

Article  CAS  PubMed  Google Scholar 

Sangiorgi, E. & Capecchi, M. R. Bmi1 is expressed in vivo in intestinal stem cells. Nat. Genet. 40, 915–920 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Breault, D. T. et al. Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proc. Natl Acad. Sci. USA 105, 10420–10425 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tian, H. et al. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature 478, 255–259 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ayyaz, A. et al. Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell. Nature 569, 121–125 (2019).

Article  CAS  PubMed  Google Scholar 

Jadhav, U. et al. Dynamic reorganization of chromatin accessibility signatures during dedifferentiation of secretory precursors into Lgr5+ intestinal stem cells. Cell Stem Cell 21, 65–77.e5 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murata, K. et al. Ascl2-dependent cell dedifferentiation drives regeneration of ablated intestinal stem cells. Cell Stem Cell 26, 377–390.e6 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tan, S. H. et al. A constant pool of Lgr5+ intestinal stem cells is required for intestinal homeostasis. Cell Rep. 34, 108633 (2021).

Article  CAS  PubMed  Google Scholar 

Yu, S. et al. Paneth cell multipotency induced by notch activation following injury. Cell Stem Cell 23, 46–59.e5 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jones, J. C. et al. Cellular plasticity of defa4-expressing Paneth cells in response to notch activation and intestinal injury. Cell Mol. Gastroenterol. Hepatol. 7, 533–554 (2019).

Article  PubMed  Google Scholar 

Schmitt, M. et al. Paneth cells respond to inflammation and contribute to tissue regeneration by acquiring stem-like features through SCF/c-Kit signaling. Cell Rep. 24, 2312–2328.e7 (2018).

Article  CAS  PubMed  Google Scholar 

de Sousa e Melo, F. & de Sauvage, F. J. Cellular plasticity in intestinal homeostasis and disease. Cell Stem Cell 24, 54–64 (2019).

Article  PubMed  Google Scholar 

van Es, J. H. et al. Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nat. Cell Biol. 14, 1099–1104 (2012).

Article  PubMed  PubMed Central  Google Scholar 

Tetteh, P. W. et al. Replacement of lost Lgr5-positive stem cells through plasticity of their enterocyte-lineage daughters. Cell Stem Cell 18, 203–213 (2016).

Article  CAS  PubMed  Google Scholar 

Sato, T. et al. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469, 415–418 (2011).

Article  CAS  PubMed