Gonzalez, F. J., Xie, C. & Jiang, C. The role of hypoxia-inducible factors in metabolic diseases. Nat. Rev. Endocrinol. 15, 21–32 (2019).
Yuan, X., Ruan, W., Bobrow, B., Carmeliet, P. & Eltzschig, H. K. Targeting hypoxia-inducible factors: therapeutic opportunities and challenges. Nat. Rev. Drug Discov. 23, 175–200 (2023).
Taylor, C. T. & Colgan, S. P. Regulation of immunity and inflammation by hypoxia in immunological niches. Nat. Rev. Immunol. 17, 774–785 (2017).
Article CAS PubMed PubMed Central Google Scholar
Wicks, E. E. & Semenza, G. L. Hypoxia-inducible factors: cancer progression and clinical translation. J. Clin. Invest. 132, e159839 (2022).
Article CAS PubMed PubMed Central Google Scholar
Kaelin, W. G. & Ratcliffe, P. J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 30, 393–402 (2008). A review of the PHD and HIF oxygen-sensing pathways.
Article CAS PubMed Google Scholar
Lim, H. S. Cardiogenic shock: failure of oxygen delivery and oxygen utilization. Clin. Cardiol. 39, 477–483 (2016).
Article PubMed PubMed Central Google Scholar
Shepherd, S. J. & Pearse, R. M. Role of central and mixed venous oxygen saturation measurement in perioperative care. Anesthesiology 111, 649–656 (2009).
Dunn, J. O. C., Mythen, M. G. & Grocott, M. P. Physiology of oxygen transport. BJA Educ. 16, 341–348 (2016).
Ahmed, M. H., Ghatge, M. S. & Safo, M. K. Hemoglobin: structure, function and allostery. in Subcellular Biochemistry Vol. 94, 345–382 (Springer, 2020).
Pittman, R. N. Oxygen transport and exchange in the microcirculation. Microcirculation 12, 59–70 (2005).
Article CAS PubMed Google Scholar
Krogh, A. The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue. J. Physiol. 52, 409–415 (1919).
Article CAS PubMed PubMed Central Google Scholar
Poole, D. C. & Musch, T. I. Capillary-mitochondrial oxygen transport in muscle: paradigm shifts. Function 4, zqad013 (2023).
Article PubMed PubMed Central Google Scholar
Beck, K. C. et al. Relationship between cardiac output and oxygen consumption during upright cycle exercise in healthy humans. J. Appl. Physiol. 101, 1474–1480 (2006).
Fitzgerald, M. P. The changes in the breathing and the blood at various high altitudes. Philos. Trans. R. Soc. Lond. 203, 351–371 (1913). Seminal paper describing the compensatory physiological changes in response to altitude and its consequent hypobaric hypoxia, demonstrating that oxygen-sensing systems are at play.
Esipova, T. V. et al. Oxyphor 2P: a high-performance probe for deep-tissue longitudinal oxygen imaging. Cell Metab. 29, 736–744.e7 (2019).
Article CAS PubMed PubMed Central Google Scholar
Narazaki, A. et al. Determination of the physiological range of oxygen tension in bone marrow monocytes using two-photon phosphorescence lifetime imaging microscopy. Sci. Rep. https://doi.org/10.1038/s41598-022-07521-9 (2022).
Lebedev, A. Y., Troxler, T. & Vinogradov, S. A. Design of metalloporphyrin-based dendritic nanoprobes for two-photon microscopy of oxygen. J. Porphyr. Phthalocyanines 12, 1261–1269 (2008).
Article CAS PubMed PubMed Central Google Scholar
Finikova, O. S. et al. Oxygen microscopy by two-photon-excited phosphorescence. ChemPhysChem 9, 1673–1679 (2008). The article describing the development of a method to measure tissue oxygenation using intravital microscopy and a metalloporphyrin-based nanoprobe, in live animals.
Article CAS PubMed PubMed Central Google Scholar
Leach, R. M. & Treacher, D. F. The pulmonary physician in critical care 2: oxygen delivery and consumption in the critically ill. Thorax 57, 170–177 (2002).
Article CAS PubMed PubMed Central Google Scholar
Carreau, A., Hafny-Rahbi, B., El Matejuk, A., Grillon, C. & Kieda, C. Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia. J. Cell. Mol. Med. 15, 1239–1253 (2011).
Article CAS PubMed PubMed Central Google Scholar
McKeown, S. R. Defining normoxia, physoxia and hypoxia in tumours — implications for treatment response. Br. J. Radiol. 87, 20130676 (2014).
Article CAS PubMed PubMed Central Google Scholar
Schell, R. M. & Cole, D. J. Cerebral monitoring: jugular venous oximetry. Anesth. Analg. 90, 559–566 (2000).
Article CAS PubMed Google Scholar
Lyons, D. G., Parpaleix, A., Roche, M. & Charpak, S. Mapping oxygen concentration in the awake mouse brain. eLife 5, e12024 (2016).
Ortiz-Prado, E., Natah, S., Srinivasan, S. & Dunn, J. F. A method for measuring brain partial pressure of oxygen in unanesthetized unrestrained subjects: the effect of acute and chronic hypoxia on brain tissue PO2. J. Neurosci. Methods 193, 217–225 (2010).
Article CAS PubMed PubMed Central Google Scholar
Kasischke, K. A. et al. Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions. J. Cereb. Blood Flow Metab. 31, 68–81 (2011).
Article CAS PubMed Google Scholar
Sakadžić, S. et al. Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue. Nat. Commun. 5, 5734 (2014).
Lecoq, J. et al. Odor-evoked oxygen consumption by action potential and synaptic transmission in the olfactory bulb. J. Neurosci. 29, 1424–1433 (2009).
Article CAS PubMed PubMed Central Google Scholar
Parpaleix, A., Houssen, Y. G. & Charpak, S. Imaging local neuronal activity by monitoring PO2 transients in capillaries. Nat. Med. 19, 241–246 (2013).
Article CAS PubMed Google Scholar
Thompson, J. K., Peterson, M. R. & Freeman, R. D. Single-neuron activity and tissue oxygenation in the cerebral cortex. Science 299, 1070–1072 (2003).
Article CAS PubMed Google Scholar
Li, Q. & Barres, B. A. Microglia and macrophages in brain homeostasis and disease. Nat. Rev. Immunol. 18, 225–242 (2018).
Article CAS PubMed Google Scholar
Gorelick, P. B. et al. Vascular contributions to cognitive impairment and dementia. Stroke 42, 2672–2713 (2011).
Article PubMed PubMed Central Google Scholar
Ema, H. & Suda, T. Two anatomically distinct niches regulate stem cell activity. Blood 120, 2174–2181 (2012).
Article CAS PubMed Google Scholar
Parmar, K., Mauch, P., Vergilio, J. A., Sackstein, R. & Down, J. D. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc. Natl Acad. Sci. USA 104, 5431–5436 (2007). Important paper linking stemness to bone marrow vasculature and oxygenation.
留言 (0)