Anderson CP, Park SY (2023) Attenuated reactive hyperemia after prolonged sitting is associated with reduced local skeletal muscle metabolism: insight from artificial intelligence. Am J Physiol Regul Integr Comp Physiol 325:R380–R388. https://doi.org/10.1152/ajpregu.00067.2023

Article  PubMed  CAS  Google Scholar 

Boone J, Celie B, Dumortier J, Barstow TJ, De Bleecker J, Smet J, Van Lander A, Van Coster R, Bourgois J (2014) Forearm muscle oxygenation responses during and following arterial occlusion in patients with mitochondrial myopathy. Respir Physiol Neurobiol 190:70–75. https://doi.org/10.1016/j.resp.2013.09.007

Article  PubMed  Google Scholar 

Bull FC, Al-Ansari SS, Biddle S et al (2020) World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med 54:1451–1462. https://doi.org/10.1136/bjsports-2020-102955

Article  PubMed  Google Scholar 

Cottin Y, Walker P, Rouhier-Marcer I, Cohen M, Louis P, Didier JP, Casillas JM, Wolf JE, Brunotte F (1996) Relationship between increased peak oxygen uptake and modifications in skeletal muscle metabolism following rehabilitation after myocardial infarction. J Cardiopulm Rehabil 16:169–174. https://doi.org/10.1097/00008483-199605000-00004

Article  PubMed  CAS  Google Scholar 

de Oliveira GV, Volino-Souza M, Leitão R, Pinheiro V, Alvares TS (2020) Is flow-mediated dilatation associated with near-infrared spectroscopy-derived magnitude of muscle O2 desaturation in healthy young and individuals at risk for cardiovascular disease? Microvasc Res 129:103967. https://doi.org/10.1016/j.mvr.2019.103967

Article  PubMed  CAS  Google Scholar 

Dipla K, Triantafyllou A, Grigoriadou I, Kintiraki E, Triantafyllou GA, Poulios P, Vrabas IS, Zafeiridis A, Douma S, Goulis DG (2017) Impairments in microvascular function and skeletal muscle oxygenation in women with gestational diabetes mellitus: links to cardiovascular disease risk factors. Diabetologia 60:192–201. https://doi.org/10.1007/s00125-016-4129-7

Article  PubMed  CAS  Google Scholar 

Evans WS, Stoner L, Willey Q, Kelsch E, Credeur DP, Hanson ED (2019) Local exercise does not prevent the aortic stiffening response to acute prolonged sitting: a randomized crossover trial. J Appl Physiol 127:781–787. https://doi.org/10.1152/japplphysiol.00318.2019

Article  PubMed  Google Scholar 

Grassi B, Quaresima V (2016) Near-infrared spectroscopy and skeletal muscle oxidative function in vivo in health and disease: a review from an exercise physiology perspective. J Biomed Opt 21:091313. https://doi.org/10.1117/1.JBO.21.9.091313

Article  PubMed  Google Scholar 

Hawkins S, Wiswell R (2003) Rate and mechanism of maximal oxygen consumption decline with aging: implications for exercise training. Sports Med 33:877–888. https://doi.org/10.2165/00007256-200333120-00002

Article  PubMed  Google Scholar 

Headid RJ 3rd, Pekas EJ, Wooden TK, Son WM, Layec G, Shin J, Park SY (2020) Impacts of prolonged sitting with mild hypercapnia on vascular and autonomic function in healthy recreationally active adults. Am J Physiol Heart Circ Physiol 319:H468–H480. https://doi.org/10.1152/ajpheart.00354.2020

Article  PubMed  PubMed Central  CAS  Google Scholar 

Horiuchi M, Stoner L (2021) Effects of compression stockings on lower-limb venous and arterial system responses to prolonged sitting: a randomized cross-over trial. Vasc Med 26:386–393. https://doi.org/10.1177/1358863X20988899

Article  PubMed  CAS  Google Scholar 

Horiuchi M, Stoner L (2022) Macrovascular and microvascular responses to prolonged sitting with and without bodyweight exercise interruptions: a randomized cross-over trial. Vasc Med 27:127–135. https://doi.org/10.1177/1358863X211053381

Article  PubMed  CAS  Google Scholar 

Horiuchi M, Endo J, Thijssen DHJ (2015) Impact of ischemic preconditioning on functional sympatholysis during handgrip exercise in humans. Physiol Rep 3:e12304. https://doi.org/10.14814/phy2.12304

Article  PubMed  PubMed Central  Google Scholar 

Kurosawa Y, Nirengi S, Tabata I, Isaka T, Clark JF, Hamaoka T (2022) Effects of prolonged sitting with or without elastic garments on limb volume, arterial blood flow, and muscle oxygenation. Med Sci Sports Exerc 54:399–407. https://doi.org/10.1249/MSS.0000000000002822

Article  PubMed  CAS  Google Scholar 

McLay KM, Fontana FY, Nederveen JP, Guida FF, Paterson DH, Pogliaghi S, Murias JM (2016) Vascular responsiveness determined by near-infrared spectroscopy measures of oxygen saturation. Exp Physiol 101:34–40. https://doi.org/10.1113/EP085406

Article  PubMed  CAS  Google Scholar 

Morishima T, Restaino RM, Walsh LK, Kanaley JA, Fadel PJ, Padilla J (2016) Prolonged sitting-induced leg endothelial dysfunction is prevented by fidgeting. Am J Physiol Heart Circ Physiol 311:H177–H182. https://doi.org/10.1152/ajpheart.00297.2016

Article  PubMed  PubMed Central  Google Scholar 

Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE (2002) Exercise capacity and mortality among men referred for exercise testing. N Engl J Med 346:793–801. https://doi.org/10.1056/NEJMoa011858

Article  PubMed  Google Scholar 

Padilla J, Fadel PJ (2017) Prolonged sitting leg vasculopathy: contributing factors and clinical implications. Am J Physiol Heart Circ Physiol 313:H722–H728. https://doi.org/10.1152/ajpheart.00326.2017

Article  PubMed  PubMed Central  CAS  Google Scholar 

Park S-Y, Wooden TK, Pekas EJ, Anderson CP, Yadav SK, Slivka DR, Layec G (2022) Effects of passive and active leg movements to interrupt sitting in mild hypercapnia on cardiovascular function in healthy adults. J Appl Physiol 132:874–887. https://doi.org/10.1152/japplphysiol.00799.2021

Article  PubMed  PubMed Central  Google Scholar 

Pekas EJ, Allen MF, Park SY (2023) Prolonged sitting and peripheral vascular function: potential mechanisms and methodological considerations. J Appl Physiol 134:810–822. https://doi.org/10.1152/japplphysiol.00730.2022

Article  PubMed  PubMed Central  Google Scholar 

Pinto AJ, Bergouignan A, Dempsey PC, Roschel H, Owen N, Gualano B, Dunstan DW (2023) Physiology of sedentary behavior. Physiol Rev 103:2561–2622. https://doi.org/10.1152/physrev.00022.2022

Article  PubMed  CAS  Google Scholar 

Restaino RM, Holwerda SW, Credeur DP, Fadel PJ, Padilla J (2015) Impact of prolonged sitting on lower and upper limb micro- and macrovascular dilator function. Exp Physiol 100:829–838. https://doi.org/10.1113/EP085238

Article  PubMed  Google Scholar 

Rosenberg DE, Bull FC, Marshall AL, Sallis JF, Bauman AE (2008) Assessment of sedentary behavior with the international physical activity questionnaire. J Phys Act Health 5(Suppl 1):S30–S44. https://doi.org/10.1123/jpah.5.s1.s30

Article  PubMed  Google Scholar 

Ryan TE, Southern WM, Reynolds MA, McCully KK (2013) A cross-validation of near-infrared spectroscopy measurements of skeletal muscle oxidative capacity with phosphorus magnetic resonance spectroscopy. J Appl Physiol 115:1757–1766. https://doi.org/10.1152/japplphysiol.00835.2013

Article  PubMed  PubMed Central  Google Scholar 

Sasazuki S, Inoue M, Tsuji I et al (2011) Body mass index and mortality from all causes and major causes in Japanese: results of a pooled analysis of 7 large-scale cohort studies. J Epidemiol 21:417–430. https://doi.org/10.2188/jea.je20100180

Article  PubMed  PubMed Central  Google Scholar 

Shvartz E, Gaume JG, White RT, Reibold RC (1983) Hemodynamic responses during prolonged sitting. J Appl Physiol Respir Environ Exerc Physiol 54:1673–1680. https://doi.org/10.1152/jappl.1983.54.6.1673

Article  PubMed  CAS  Google Scholar 

Stergiopulos N, Meister JJ, Westerhof N (1996) Determinants of stroke volume and systolic and diastolic aortic pressure. Am J Physiol 270:H2050–H2059. https://doi.org/10.1152/ajpheart.1996.270.6.H2050

Article  PubMed  CAS  Google Scholar 

Stoner L, Barone Gibbs B, Meyer ML et al (2021) A primer on repeated sitting exposure and the cardiovascular system: considerations for study design, analysis, interpretation, and translation. Front Cardiovasc Med 8:716938.