Lipolysis-stimulated lipoprotein receptor promote lipid uptake and fatty acid oxidation in gastric cancer

Smyth EC, Nilsson M, Grabsch HI, van Grieken NC, Lordick F. Gastric cancer. Lancet. 2020;396:635–48.

Article  CAS  PubMed  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49.

Article  PubMed  Google Scholar 

Yanagimoto Y, Kurokawa Y, Doki Y. Essential updates 2021/2022: Perioperative and surgical treatments for gastric and esophagogastric junction cancer. Ann Gastroenterol Surg. 2023;7:698–708.

Article  PubMed  PubMed Central  Google Scholar 

Yamashita K, Hosoda K, Niihara M, Hiki N. History and emerging trends in chemotherapy for gastric cancer. Ann Gastroenterol Surg. 2021;5:446–56.

Article  PubMed  PubMed Central  Google Scholar 

Alsina M, Arrazubi V, Diez M, Tabernero J. Current developments in gastric cancer: from molecular profiling to treatment strategy. Nat Rev Gastroenterol Hepatol. 2023;20:155–70.

Article  CAS  PubMed  Google Scholar 

Martínez-Reyes I, Chandel NS. Cancer metabolism: looking forward. Nat Rev Cancer. 2021;21:669–80.

Article  PubMed  Google Scholar 

Warburg O. On the origin of cancer cells. Science. 1956;123:309–14.

Article  CAS  PubMed  Google Scholar 

Hsu PP, Sabatini DM. Cancer cell metabolism: warburg and beyond. Cell. 2008;134:703–7.

Article  CAS  PubMed  Google Scholar 

Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009;324:1029–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schiliro C, Firestein BL. Mechanisms of metabolic reprogramming in cancer cells supporting enhanced growth and proliferation. Cells. 2021. https://doi.org/10.3390/cells10051056.

Article  PubMed  PubMed Central  Google Scholar 

Cheng C, Geng F, Cheng X, Guo D. Lipid metabolism reprogramming and its potential targets in cancer. Cancer Commun (Lond). 2018;38:27.

PubMed  Google Scholar 

Ohshima K, Morii E. Metabolic reprogramming of cancer cells during tumor progression and metastasis. Metabolites. 2021. https://doi.org/10.3390/metabo11010028.

Article  PubMed  PubMed Central  Google Scholar 

Tan Y, Li J, Zhao G, Huang KC, Cardenas H, Wang Y, et al. Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells. Nat Commun. 2022;13:4554.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hiramatsu K, Serada S, Enomoto T, Takahashi Y, Nakagawa S, Nojima S, et al. LSR antibody therapy inhibits ovarian epithelial tumor growth by inhibiting lipid uptake. Cancer Res. 2018;78:516–27.

Article  CAS  PubMed  Google Scholar 

Sugase T, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Hiramatsu K, et al. Lipolysis-stimulated lipoprotein receptor overexpression is a novel predictor of poor clinical prognosis and a potential therapeutic target in gastric cancer. Oncotarget. 2018;9:32917–28.

Article  PubMed  PubMed Central  Google Scholar 

Nagase Y, Hiramatsu K, Funauchi M, Shiomi M, Masuda T, Kakuda M, et al. Anti-lipolysis-stimulated lipoprotein receptor monoclonal antibody as a novel therapeutic agent for endometrial cancer. BMC Cancer. 2022;22:679.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yen FT, Masson M, Clossais-Besnard N, André P, Grosset JM, Bougueleret L, et al. Molecular cloning of a lipolysis-stimulated remnant receptor expressed in the liver. J Biol Chem. 1999;274:13390–8.

Article  CAS  PubMed  Google Scholar 

Bihain BE, Yen FT. The lipolysis stimulated receptor: a gene at last. Curr Opin Lipidol. 1998;9:221–4.

Article  CAS  PubMed  Google Scholar 

Sugase T, Takahashi T, Serada S, Nakatsuka R, Fujimoto M, Ohkawara T, et al. Suppressor of cytokine signaling-1 gene therapy induces potent antitumor effect in patient-derived esophageal squamous cell carcinoma xenograft mice. Int J Cancer. 2017;140:2608–21.

Article  CAS  PubMed  Google Scholar 

Sugase T, Takahashi T, Serada S, Fujimoto M, Hiramatsu K, Ohkawara T, et al. SOCS1 gene therapy improves radiosensitivity and enhances irradiation-induced DNA damage in esophageal squamous cell carcinoma. Cancer Res. 2017;77:6975–86.

Article  CAS  PubMed  Google Scholar 

Iwahashi N, Ikezaki M, Fujimoto M, Komohara Y, Fujiwara Y, Yamamoto M, et al. Lipid droplet accumulation independently predicts poor clinical prognosis in high-grade serous ovarian carcinoma. Cancers (Basel). 2021. https://doi.org/10.3390/cancers13205251.

Article  PubMed  PubMed Central  Google Scholar 

Fujimoto M, Matsuzaki I, Yamamoto Y, Yoshizawa A, Warigaya K, Iwahashi Y, et al. Adipophilin expression in cutaneous malignant melanoma. J Cutan Pathol. 2017;44:228–36.

Article  PubMed  Google Scholar 

Medes G, Thomas A, Weinhouse S. Metabolism of neoplastic tissue .IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res. 1953;13(1):27–9.

CAS  PubMed  Google Scholar 

Pascual G, Avgustinova A, Mejetta S, Martín M, Castellanos A, Attolini CS, et al. Targeting metastasis-initiating cells through the fatty acid receptor CD36. Nature. 2017;541:41–5.

Article  CAS  PubMed  Google Scholar 

Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med. 2011;17:1498–503.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Judge A, Dodd MS. Metabolism. Essays Biochem. 2020;64:607–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Olzmann JA, Carvalho P. Dynamics and functions of lipid droplets. Nat Rev Mol Cell Biol. 2019;20:137–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin Y, Tan Y, Wu J, Ren Z. Lipid droplets: a cellular organelle vital in cancer cells. Cell Death Discov. 2023;9:254.

Article  CAS  PubMed  PubMed Central  Google Scholar 

García JM, Peña C, García V, Domínguez G, Muñoz C, Silva J, et al. Prognostic value of LISCH7 mRNA in plasma and tumor of colon cancer patients. Clin Cancer Res. 2007;13:6351–8.

Article  PubMed  Google Scholar 

Zhang M, Ma C. LSR promotes cell proliferation and invasion in lung cancer. Comput Math Methods Med. 2021;2021:6651907.

PubMed  PubMed Central  Google Scholar 

Fujiwara N, Nakagawa H, Enooku K, Kudo Y, Hayata Y, Nakatsuka T, et al. CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity. Gut. 2018;67:1493–504.

Article  CAS  PubMed 

留言 (0)

沒有登入
gif