Acceptance of emerging renal oncocytic neoplasms: a survey of urologic pathologists

Hes O, Trpkov K (2022) Do we need an updated classification of oncocytic renal tumors? : emergence of low-grade oncocytic tumor (LOT) and eosinophilic vacuolated tumor (EVT) as novel renal entities. Mod Pathol 35(9):1140–1150

PubMed  Google Scholar 

Amin MB, McKenney JK, Martignoni G, Campbell SC, Pal S, Tickoo SK (2022) Low grade oncocytic tumors of the kidney: a clinically relevant approach for the workup and accurate diagnosis. Mod Pathol 35(10):1306–1316

PubMed  Google Scholar 

Samaratunga H, Egevad L, Thunders M, Iczskowski KA, van der Kwast T, Kristiansen G et al (2022) LOT and HOT … or not. The proliferation of clinically insignificant and poorly characterised types of renal neoplasia. Pathology 54(7):842–7

PubMed  Google Scholar 

Siadat F, Trpkov K (2020) ESC, ALK, HOT and LOT: three letter acronyms of emerging renal entities knocking on the door of the WHO classification. Cancers (Basel) 12(1):168

PubMed  Google Scholar 

Trpkov K, Williamson SR, Gill AJ, Adeniran AJ, Agaimy A, Alaghehbandan R et al (2021) Novel, emerging and provisional renal entities: the Genitourinary Pathology Society (GUPS) update on renal neoplasia. Mod Pathol 34(6):1167–1184

PubMed  Google Scholar 

Argani P, McKenney JK, Hartmann A, Hes O, Magi-Galluzzi C, Trpkov K (2022) Eosinophilic solid and cystic renal cell carcinoma: IARC [Available from: https://tumourclassification.iarc.who.int/chaptercontent/36/23

McKenney JK, Przybycin CG, Trpkov K, Magi-Galluzzi C (2018) Eosinophilic solid and cystic renal cell carcinomas have metastatic potential. Histopathology 72(6):1066–1067

PubMed  Google Scholar 

Mehra R, Vats P, Cao X, Su F, Lee ND, Lonigro R et al (2018) Somatic Bi-allelic loss of TSC genes in eosinophilic solid and cystic renal cell carcinoma. Eur Urol 74(4):483–486

PubMed  PubMed Central  Google Scholar 

Palsgrove DN, Li Y, Pratilas CA, Lin MT, Pallavajjalla A, Gocke C et al (2018) Eosinophilic solid and cystic (ESC) renal cell carcinomas harbor TSC mutations: molecular analysis supports an expanding clinicopathologic spectrum. Am J Surg Pathol 42(9):1166–1181

PubMed  PubMed Central  Google Scholar 

Parilla M, Kadri S, Patil SA, Ritterhouse L, Segal J, Henriksen KJ et al (2018) Are sporadic eosinophilic solid and cystic renal cell carcinomas characterized by somatic tuberous sclerosis gene mutations? Am J Surg Pathol 42(7):911–917

PubMed  Google Scholar 

Trpkov K, Abou-Ouf H, Hes O, Lopez JI, Nesi G, Comperat E et al (2017) Eosinophilic solid and cystic renal cell carcinoma (ESC RCC): further morphologic and molecular characterization of ESC RCC as a distinct entity. Am J Surg Pathol 41(10):1299–1308

PubMed  Google Scholar 

Trpkov K, Hes O, Bonert M, Lopez JI, Bonsib SM, Nesi G et al (2016) Eosinophilic, solid, and cystic renal cell carcinoma: clinicopathologic study of 16 unique, sporadic neoplasms occurring in women. Am J Surg Pathol 40(1):60–71

PubMed  Google Scholar 

Williamson SR, Gadde R, Trpkov K, Hirsch MS, Srigley JR, Reuter VE et al (2017) Diagnostic criteria for oncocytic renal neoplasms: a survey of urologic pathologists. Hum Pathol 63:149–156

PubMed  Google Scholar 

Akgul M, Al-Obaidy KI, Cheng L, Idrees MT (2021) Low-grade oncocytic tumour expands the spectrum of renal oncocytic tumours and deserves separate classification: a review of 23 cases from a single tertiary institute. J Clin Pathol 75:772

PubMed  Google Scholar 

Guo Q, Liu N, Wang F, Guo Y, Yang B, Cao Z et al (2021) Characterization of a distinct low-grade oncocytic renal tumor (CD117-negative and cytokeratin 7-positive) based on a tertiary oncology center experience: the new evidence from China. Virchows Arch 478(3):449–458

PubMed  Google Scholar 

Kapur P, Gao M, Zhong H, Chintalapati S, Mitui M, Barnes SD et al (2021) Germline and sporadic mTOR pathway mutations in low-grade oncocytic tumor of the kidney. Mod Pathol 35:333–343

PubMed  PubMed Central  Google Scholar 

Kravtsov O, Gupta S, Cheville JC, Sukov WR, Rowsey R, Herrera-Hernandez LP et al (2021) Low-grade oncocytic tumor of kidney (CK7-positive, CD117-negative): incidence in a single institutional experience with clinicopathological and molecular characteristics. Hum Pathol 114:9–18

PubMed  Google Scholar 

Morini A, Drossart T, Timsit MO, Sibony M, Vasiliu V, Gimenez-Roqueplo AP et al (2021) Low-grade oncocytic renal tumor (LOT): mutations in mTOR pathway genes and low expression of FOXI1. Mod Pathol 35:352–360

PubMed  Google Scholar 

Trpkov K, Williamson SR, Gao Y, Martinek P, Cheng L, Sangoi AR et al (2019) Low-grade oncocytic tumour of kidney (CD117-negative, cytokeratin 7-positive): a distinct entity? Histopathology 75(2):174–184

PubMed  Google Scholar 

Williamson SR, Hes O, Trpkov K, Aggarwal A, Satapathy A, Mishra S et al (2023) Low-grade oncocytic tumour of the kidney is characterised by genetic alterations of TSC1, TSC2, MTOR or PIK3CA and consistent GATA3 positivity. Histopathology 82(2):296–304

PubMed  Google Scholar 

Alghamdi M, Chen JF, Jungbluth A, Koutzaki S, Palmer MB, Al-Ahmadie HA et al (2024) L1 cell adhesion molecule (L1CAM) expression and molecular alterations distinguish low-grade oncocytic tumor from eosinophilic chromophobe renal cell carcinoma. Mod Pathol 37(5):100467

PubMed  Google Scholar 

Chen YB, Mirsadraei L, Jayakumaran G, Al-Ahmadie HA, Fine SW, Gopalan A et al (2019) Somatic mutations of TSC2 or MTOR characterize a morphologically distinct subset of sporadic renal cell carcinoma with eosinophilic and vacuolated cytoplasm. Am J Surg Pathol 43(1):121–131

PubMed  PubMed Central  Google Scholar 

Farcas M, Gatalica Z, Trpkov K, Swensen J, Zhou M, Alaghehbandan R et al (2021) Eosinophilic vacuolated tumor (EVT) of kidney demonstrates sporadic TSC/MTOR mutations: next-generation sequencing multi-institutional study of 19 cases. Mod Pathol 34:2243

PubMed  Google Scholar 

He H, Trpkov K, Martinek P, Isikci OT, Maggi-Galuzzi C, Alaghehbandan R et al (2018) “High-grade oncocytic renal tumor”: morphologic, immunohistochemical, and molecular genetic study of 14 cases. Virchows Arch 473(6):725–738

PubMed  Google Scholar 

Tjota M, Chen H, Parilla M, Wanjari P, Segal J, Antic T (2020) Eosinophilic renal cell tumors with a TSC and MTOR gene mutations are morphologically and immunohistochemically heterogenous: clinicopathologic and molecular study. Am J Surg Pathol 44:943–954

PubMed  Google Scholar 

Trpkov K, Bonert M, Gao Y, Kapoor A, He H, Yilmaz A et al (2019) High-grade oncocytic tumour (HOT) of kidney in a patient with tuberous sclerosis complex. Histopathology 75(3):440–442

PubMed  Google Scholar 

Salles DC, Asrani K, Woo J, Vidotto T, Liu HB, Vidal I et al (2022) GPNMB expression identifies TSC1/2/mTOR-associated and MiT family translocation-driven renal neoplasms. J Pathol 257:158–171

PubMed  PubMed Central  Google Scholar 

Li H, Argani P, Halper-Stromberg E, Lotan TL, Merino MJ, Reuter VE et al (2023) Positive GPNMB immunostaining differentiates renal cell carcinoma with fibromyomatous stroma associated with TSC1/2/MTOR alterations from others. Am J Surg Pathol 47(11):1267–1273

PubMed  Google Scholar 

Richard PO, Jewett MA, Bhatt JR, Evans AJ, Timilsina N, Finelli A (2016) Active surveillance for renal neoplasms with oncocytic features is safe. J Urol 195(3):581–586

PubMed  Google Scholar 

Guo J, Tretiakova MS, Troxell ML, Osunkoya AO, Fadare O, Sangoi AR et al (2014) Tuberous sclerosis-associated renal cell carcinoma: a clinicopathologic study of 57 separate carcinomas in 18 patients. Am J Surg Pathol 38(11):1457–1467

PubMed  Google Scholar 

Yang P, Cornejo KM, Sadow PM, Cheng L, Wang M, Xiao Y et al (2014) Renal cell carcinoma in tuberous sclerosis complex. Am J Surg Pathol 38(7):895–909

PubMed  PubMed Central  Google Scholar 

Kunju LP, Wojno K, Wolf JS Jr, Cheng L, Shah RB (2008) Papillary renal cell carcinoma with oncocytic cells and nonoverlapping low grade nuclei: expanding the morphologic spectrum with emphasis on clinicopathologic, immunohistochemical and molecular features. Hum Pathol 39(1):96–101

PubMed  Google Scholar 

Al-Obaidy KI, Eble JN, Cheng L, Williamson SR, Sakr WA, Gupta N et al (2019) Papillary renal neoplasm with reverse polarity: a morphologic, immunohistochemical, and molecular study. Am J Surg Pathol 43(8):1099–1111

PubMed  Google Scholar 

Han G, Yu W, Chu J, Liu Y, Jiang Y, Li Y et al (2017) Oncocytic papillary renal cell carcinoma: a clinicopathological and genetic analysis and indolent clinical course in 14 cases. Pathol Res Pract 213(1):1–6

PubMed  Google Scholar 

Lefevre M, Couturier J, Sibony M, Bazille C, Boyer K, Callard P et al (2005) Adult papillary renal tumor with oncocytic cells: clinicopathologic, immunohistochemical, and cytogenetic features of 10 cases. Am J Surg Pathol 29(12):1576–1581

PubMed  Google Scholar 

Nemours S, Armesto M, Arestin M, Manini C, Giustetto D, Sperga M et al (2024) Non-coding RNA and gene expression analyses of papillary renal neoplasm with reverse polarity (PRNRP) reveal distinct pathological mechanisms from other renal neoplasms. Pathology 56(4):493–503

PubMed  Google Scholar 

Kiyozawa D, Iwasaki T, Takamatsu D, Kohashi K, Miyamoto T, Fukuchi G et al (2024) Papillary renal neoplasm with reverse polarity has low frequency of alterations in chromosomes 7, 17, and Y. Virchows Arch 485:299–306

PubMed  Google Scholar 

Castillo VF, Trpkov K, Van der Kwast T, Rotondo F, Hamdani M, Saleeb R (2024) Papillary renal neoplasm with reverse polarity is biologically and clinically distinct from eosinophilic papillary renal cell carcinoma. Pathol Int 74(4):222–226

PubMed  Google Scholar 

Satturwar S, Parwani AV (2023) Cytomorphology of papillary renal neoplasm with reverse polarity. Cytojournal 20:43

PubMed  PubMed Central  Google Scholar 

Nova-Camacho LM, Martin-Arruti M, Diaz IR, Panizo-Santos A (2023) Papillary renal neoplasm with reverse polarity: a clinical, pathologic, and molecular study of 8 renal tumors from a single institution. Arch Pathol Lab Med 147(6):692–700

PubMed  Google Scholar 

Kim B, Lee S, Moon KC (2023) Papillary renal neoplasm with reverse polarity: a clinicopathologic study of 43 cases with a focus on the expression of KRAS signaling pathway downstream effectors. Hum Pathol 142:1–6

PubMed 

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