McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, Burri H, Butler J, Čelutkienė J, Chioncel O et al (2023) 2023 Focused update of the 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 44(37):3627–3639

Article  CAS  PubMed  Google Scholar 

Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR et al (2022) 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 145(18):e895–e1032

PubMed  Google Scholar 

Bozkurt B, Coats AJS, Tsutsui H, Abdelhamid CM, Adamopoulos S, Albert N, Anker SD, Atherton J, Böhm M, Butler J et al (2021) Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure: Endorsed by the Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and Chinese Heart Failure Association. Eur J Heart Fail 23(3):352–380

Article  PubMed  Google Scholar 

Pinto YM (2023) Heart failure with preserved ejection fraction-a metabolic disease? N Engl J Med 389(12):1145–1146

Article  PubMed  Google Scholar 

Omote K, Verbrugge FH, Borlaug BA (2022) Heart failure with preserved ejection fraction: mechanisms and treatment strategies. Annu Rev Med 73:321–337

Article  CAS  PubMed  Google Scholar 

Kittleson MM, Panjrath GS, Amancherla K, Davis LL, Deswal A, Dixon DL, Januzzi JL, Yancy CW (2023) 2023 ACC expert consensus decision pathway on management of heart failure with preserved ejection fraction: a report of the American College of Cardiology solution set oversight committee. J Am Coll Cardiol 81(18):1835–1878

Article  PubMed  Google Scholar 

eBioMedicine: Obesity and heart failure with preserved ejection fraction (HFprEF): the whole body question. EBioMedicine 2023, 97:104874.

Borlaug BA, Jensen MD, Kitzman DW, Lam CSP, Obokata M, Rider OJ (2023) Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets. Cardiovasc Res 118(18):3434–3450

Article  PubMed  Google Scholar 

Dhore-Patil A, Thannoun T, Samson R, Le Jemtel TH (2021) Diabetes mellitus and heart failure with preserved ejection fraction: role of obesity. Front Physiol 12:785879

Article  PubMed  Google Scholar 

Martens P, Mathieu C, Vanassche T (2023) The use of glucagon-like-peptide-1 receptor agonist in the cardiology practice. Acta Cardiol 78(5):552–564

Article  CAS  PubMed  Google Scholar 

Mahapatra MK, Karuppasamy M, Sahoo BM (2022) Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes. Rev Endocr Metab Disord 23(3):521–539

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kosiborod MN, Petrie MC, Borlaug BA, Butler J, Davies MJ, Hovingh GK, Kitzman DW, Møller DV, Treppendahl MB, Verma S et al (2024) Semaglutide in patients with obesity-related heart failure and type 2 diabetes. N Engl J Med 390(15):1394–1407

Article  CAS  PubMed  Google Scholar 

Daou D, Gillette TG, Hill JA, (2023): Inflammatory mechanisms in heart failure with preserved ejection fraction. Physiology (Bethesda), 38(5):0

Prausmüller S, Weidenhammer A, Heitzinger G, Spinka G, Goliasch G, Arfsten H, Abdel Mawgoud R, Gabler C, Strunk G, Hengstenberg C et al (2023) Obesity in heart failure with preserved ejection fraction with and without diabetes: risk factor or innocent bystander? Eur J Prev Cardiol 30(12):1247–1254

Article  PubMed  Google Scholar 

Jung M-H, Shin M-S (2023) Obesity-related heart failure with preserved ejection fraction: diagnostic and therapeutic challenges. Korean J Intern Med 38(2):157–166

Article  CAS  PubMed  PubMed Central  Google Scholar 

He J, Yang W, Wu W, Sun X, Li S, Yin G, Zhuang B, Xu J, Zhou D, Zhang Y et al (2023) Clinical features, myocardial strain and tissue characteristics of heart failure with preserved ejection fraction in patients with obesity: a prospective cohort study. EClinicalMedicine 55:101723

Article  PubMed  Google Scholar 

Clemenza F, Citarrella R, Patti A, Rizzo M (2022) Obesity and HFpEF. J Clin Med 11(13):3858

Article  PubMed  PubMed Central  Google Scholar 

Koutroumpakis E, Kaur R, Taegtmeyer H, Deswal A (2021) Obesity and heart failure with preserved ejection fraction. Heart Fail Clin 17(3):345–356

Article  PubMed  Google Scholar 

Harada T, Obokata M (2020) Obesity-related heart failure with preserved ejection fraction: pathophysiology, diagnosis, and potential therapies. Heart Fail Clin 16(3):357–368

Article  PubMed  Google Scholar 

Preda A, Carbone F, Tirandi A, Montecucco F, Liberale L (2023) Obesity phenotypes and cardiovascular risk: from pathophysiology to clinical management. Rev Endocr Metab Disord 24(5):901–919

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ayton SL, Gulsin GS, McCann GP, Moss AJ (2022) Epicardial adipose tissue in obesity-related cardiac dysfunction. Heart (British Cardiac Society) 108(5):339–344

CAS  PubMed  Google Scholar 

Chin JF, Aga YS, Abou Kamar S, Kroon D, Snelder SM, van de Poll SWE, Kardys I, Brugts JJ, de Boer RA, van Dalen BM (2023) Association between epicardial adipose tissue and cardiac dysfunction in subjects with severe obesity. Eur J Heart Fail 25(11):1936–1943

Article  CAS  PubMed  Google Scholar 

Salvatore T, Galiero R, Caturano A, Vetrano E, Rinaldi L, Coviello F, Di Martino A, Albanese G, Colantuoni S, Medicamento G et al (2022) Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes. Biomolecules 12(2):176

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi Y-J, Dong G-J, Guo M (2023) Targeting epicardial adipose tissue: a potential therapeutic strategy for heart failure with preserved ejection fraction with type 2 diabetes mellitus. World J Diabetes 14(6):724–740

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Woerden G, van Veldhuisen DJ, Westenbrink BD, de Boer RA, Rienstra M, Gorter TM (2022) Connecting epicardial adipose tissue and heart failure with preserved ejection fraction: mechanisms, management and modern perspectives. Eur J Heart Fail 24(12):2238–2250

Article  PubMed  Google Scholar 

Borlaug BA (2020) Evaluation and management of heart failure with preserved ejection fraction. Nat Rev Cardiol 17(9):559–573

Article  CAS  PubMed  Google Scholar 

Pieske B, Tschöpe C, de Boer RA, Fraser AG, Anker SD, Donal E, Edelmann F, Fu M, Guazzi M, Lam CSP et al (2019) How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur Heart J 40(40):3297–3317

Article  PubMed  Google Scholar 

Verbrugge FH, Omote K, Reddy YNV, Sorimachi H, Obokata M, Borlaug BA (2022) Heart failure with preserved ejection fraction in patients with normal natriuretic peptide levels is associated with increased morbidity and mortality. Eur Heart J 43(20):1941–1951

Article  CAS  PubMed  PubMed Central  Google Scholar 

Obokata M, Reddy YNV, Melenovsky V, Sorimachi H, Jarolim P, Borlaug BA (2022) Uncoupling between intravascular and distending pressures leads to underestimation of circulatory congestion in obesity. Eur J Heart Fail 24(2):353–361

Article  CAS  PubMed  Google Scholar 

Lee VYJ, Houston L, Perkovic A, Barraclough JY, Sweeting A, Yu J, Fletcher RA, Arnott C (2024) The effect of weight loss through lifestyle interventions in patients with heart failure with preserved ejection fraction-a systematic review and meta-analysis of randomised controlled trials. Heart Lung Circ 33(2):197–208

Article  PubMed  Google Scholar 

Mikhalkova D, Holman SR, Jiang H, Saghir M, Novak E, Coggan AR, O’Connor R, Bashir A, Jamal A, Ory DS et al (2018) Bariatric surgery-induced cardiac and lipidomic changes in obesity-related heart failure with preserved ejection fraction. Obesity (Silver Spring) 26(2):284–290

Article  CAS  PubMed  Google Scholar 

Packer M, Kitzman DW (2018) Obesity-related heart failure with a preserved ejection fraction: the mechanistic rationale for combining inhibitors of aldosterone, neprilysin, and sodium-glucose cotransporter-2. JACC Heart Fail 6(8):633–639