Wang M, Earley M, Chen L, Hanson BM, Yu Y, Liu Z, Salcedo S, Cober E, Li L, Kanj SS, Gao H, Munita JM, Ordoñez K, Weston G, Satlin MJ, Valderrama-Beltrán SL, Marimuthu K, Stryjewski ME, Komarow L, Luterbach C, Marshall SH, Rudin SD, Manca C, Paterson DL, Reyes J, Villegas MV, Evans S, Hill C, Arias R, Baum K, Fries BC, Doi Y, Patel R, Kreiswirth BN, Bonomo RA, Chambers HF, Fowler VG Jr, Arias CA, van Duin D. Multi-drug Resistant Organism Network investigators. Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study. Lancet Infect Dis. 2022;22(3):401–12. https://doi.org/10.1016/S1473-3099(21)00399-6.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Wang Q, Yin Y, Chen H, Jin L, Gu B, Xie L, Yang C, Ma X, Li H, Li W, Zhang X, Liao K, Man S, Wang S, Wen H, Li B, Guo Z, Tian J, Pei F, Liu L, Zhang L, Zou C, Hu T, Cai J, Yang H, Huang J, Jia X, Huang W, Cao B, Wang H. Epidemiology of Carbapenem-Resistant Enterobacteriaceae infections: Report from the China CRE Network. Antimicrob Agents Chemother. 2018;62(2):e01882–17. https://doi.org/10.1128/AAC.01882-17.

Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Ji J, Ying C, Liu Z, Yang Q, Kong H, Xiao Y, Blood Bacterial Resistant Investigation Collaborative System (BRICS) Study Group. Blood bacterial resistant investigation collaborative system (BRICS) report: a national surveillance in China from 2014 to 2019. Antimicrob Resist Infect Control. 2022;11(1):17. https://doi.org/10.1186/s13756-022-01055-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Ying S, Jiang L, Dong S, Dai J, Jin X, Yu W, Qiu Y. A Novel Nomogram for Predicting Risk factors and outcomes in Bloodstream infections caused by Klebsiella pneumoniae. Infect Drug Resist. 2022;15:1317–28. https://doi.org/10.2147/IDR.S349236.

Article  PubMed  PubMed Central  Google Scholar 

Onorato L, Sarnelli B, D’Agostino F, Signoriello G, Trama U, D’Argenzio A, Montemurro MV, Coppola N. Epidemiological, clinical and microbiological characteristics of patients with bloodstream infections due to Carbapenem-Resistant K. Pneumoniae in Southern Italy: a Multicentre Study. Antibiot (Basel). 2022;11(5):633. https://doi.org/10.3390/antibiotics11050633.

Article  CAS  Google Scholar 

Sabino S, Soares S, Ramos F, Moretti M, Zavascki AP, Rigatto MH. A cohort study of the impact of Carbapenem-Resistant Enterobacteriaceae infections on Mortality of patients presenting with Sepsis. mSphere. 2019;4(2):e00052–19. https://doi.org/10.1128/mSphere.00052-19.].

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wong Fok Lung T, Charytonowicz D, Beaumont KG, Shah SS, Sridhar SH, Gorrie CL, Mu A, Hofstaedter CE, Varisco D, McConville TH, Drikic M, Fowler B, Urso A, Shi W, Fucich D, Annavajhala MK, Khan IN, Oussenko I, Francoeur N, Smith ML, Stockwell BR, Lewis IA, Hachani A, Upadhyay Baskota S, Uhlemann AC, Ahn D, Ernst RK, Howden BP, Sebra R, Prince A. Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection. Cell Metab. 2022;34(5):761–e7749. https://doi.org/10.1016/j.cmet.2022.03.009.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feriotti C, Sá-Pessoa J, Calderón-González R, Gu L, Morris B, Sugisawa R, Insua JL, Carty M, Dumigan A, Ingram RJ, Kissenpfening A, Bowie AG, Bengoechea JA. Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity. Cell Rep. 2022;40(6):111167. https://doi.org/10.1016/j.celrep.2022.111167.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martynova E, Rizvanov A, Urbanowicz RA, Khaiboullina S. Inflammasome Contribution to the activation of Th1, Th2, and Th17 Immune responses. Front Microbiol. 2022;13:851835. https://doi.org/10.3389/fmicb.2022.851835.

Article  PubMed  PubMed Central  Google Scholar 

Olonisakin TF, Li H, Xiong Z, Kochman EJ, Yu M, Qu Y, Hulver M, Kolls JK, St Croix C, Doi Y, Nguyen MH, Shanks RM, Mallampalli RK, Kagan VE, Ray A, Silverstein RL, Ray P, Lee JS. CD36 provides host Protection Against Klebsiella pneumoniae Intrapulmonary infection by enhancing Lipopolysaccharide responsiveness and Macrophage Phagocytosis. J Infect Dis. 2016;214(12):1865–75. https://doi.org/10.1093/infdis/jiw451.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Happel KI, Dubin PJ, Zheng M, Ghilardi N, Lockhart C, Quinton LJ, Odden AR, Shellito JE, Bagby GJ, Nelson S, Kolls JK. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med. 2005;202(6):761–9. https://doi.org/10.1084/jem.20050193.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu W, Luo Q, Shen P, Chen Y, Xu H, Xiao Y, Qiu Y. New options for bloodstream infections caused by colistin- or ceftazidime/avibactam-resistant Klebsiella pneumoniae. Int J Antimicrob Agents. 2021;58(6):106458. https://doi.org/10.1016/j.ijantimicag.2021.106458.

Article  CAS  PubMed  Google Scholar 

Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. 32th informational supplement 2022. http://www.clsi.org/. Accessed February 2022.

Chen C, Chen H, Zhang Y, Thomas HR, Frank MH, He Y, Xia R. TBtools: an integrative Toolkit developed for interactive analyses of big Biological Data. Mol Plant. 2020;13(8):1194–202. https://doi.org/10.1016/j.molp.2020.06.009.

Article  CAS  PubMed  Google Scholar 

Pan H, Lou Y, Zeng L, Wang L, Zhang J, Yu W, Qiu Y. Infections caused by carbapenemase-producing Klebsiella pneumoniae: microbiological characteristics and risk factors. Microb Drug Resist. 2019;25(2):287–96. https://doi.org/10.1089/mdr.2018.0339.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Papp-Wallace KM. The latest advances in β-lactam/β-lactamase inhibitor combinations for the treatment of Gram-negative bacterial infections. Expert Opin Pharmacother. 2019;20(17):2169–84. https://doi.org/10.1080/14656566.2019.1660772.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bengoechea JA, Sa Pessoa J. Klebsiella pneumoniae infection biology: living to counteract host defences. FEMS Microbiol Rev. 2019;43(2):123–44. https://doi.org/10.1093/femsre/fuy043.

Article  CAS  PubMed  Google Scholar 

Yu W, Xiong L, Luo Q, Chen Y, Ji J, Ying C, Liu Z, Xiao Y. In Vitro Activity comparison of Ceftazidime-Avibactam and Aztreonam-Avibactam against Bloodstream infections with Carbapenem-resistant organisms in China. Front Cell Infect Microbiol. 2021;11:780365. https://doi.org/10.3389/fcimb.2021.780365.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jarczak D, Nierhaus A. Cytokine Storm-Definition, causes, and implications. Int J Mol Sci. 2022;23(19):11740. https://doi.org/10.3390/ijms231911740.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haydar D, Gonzalez R, Garvy BA, Garneau-Tsodikova S, Thamban Chandrika N, Bocklage TJ, Feola DJ. Myeloid arginase-1 controls excessive inflammation and modulates T cell responses in Pseudomonas aeruginosa pneumonia. Immunobiology. 2021;226(1):152034. https://doi.org/10.1016/j.imbio.2020.152034.

Article  CAS  PubMed  Google Scholar 

Dowling JK, Afzal R, Gearing LJ, Cervantes-Silva MP, Annett S, Davis GM, De Santi C, Assmann N, Dettmer K, Gough DJ, Bantug GR, Hamid FI, Nally FK, Duffy CP, Gorman AL, Liddicoat AM, Lavelle EC, Hess C, Oefner PJ, Finlay DK, Davey GP, Robson T, Curtis AM, Hertzog PJ, Williams BRG, McCoy CE. Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages. Nat Commun. 2021;12(1):1460. https://doi.org/10.1038/s41467-021-21617-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Joanna Homa A, Klosowska M, Chadzinska. Arginase Activity in Eisenia andrei Coelomocytes: function in the Earthworm Innate Response. Int J Mol Sci. 2021;22(7):3687. https://doi.org/10.3390/ijms22073687.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rhee C, Kadri SS, Dekker JP, Danner RL, Chen HC, Fram D, Zhang F, Wang R, Klompas M, CDC Prevention Epicenters Program. Prevalence of antibiotic-resistant pathogens in Culture-Proven Sepsis and outcomes Associated with inadequate and broad-spectrum empiric antibiotic use. JAMA Netw Open. 2020;3(4):e202899. https://doi.org/10.1001/jamanetworkopen.2020.2899.

Article  PubMed  PubMed Central  Google Scholar 

van Enckevort FH, Sweep CG, Span PN, Netea MG, Hermus AR, Kullberg BJ. Reduced adrenal response and increased mortality after systemic Klebsiella pneumoniae infection in interleukin-6-deficient mice. Eur Cytokine Netw. 2001;12(4):581–6.

PubMed