Global status report. On the public health response to dementia. Word Health Organization; 2021.

Livingston G, Huntley J, Liu KY, Costafreda SG, Selbæk G, Alladi S, et al. Dementia prevention, intervention, and care: 2024 report of the Lancet standing commission. The Lancet. 2024;404(10452):572–628.

Article  PubMed  Google Scholar 

Kivimäki M, Livingston G, Singh-Manoux A, Mars N, Lindbohm JV, Pentti J, et al. Estimating dementia risk using multifactorial prediction models. JAMA Netw Open. 2023;6(6):e2318132–e.

Article  PubMed  PubMed Central  Google Scholar 

Licher S, Yilmaz P, Leening MJG, Wolters FJ, Vernooij MW, Stephan BCM, et al. External validation of four dementia prediction models for use in the general community-dwelling population: a comparative analysis from the Rotterdam Study. Eur J Epidemiol. 2018;33(7):645–55.

Article  PubMed  PubMed Central  Google Scholar 

Hou X-H, Feng L, Zhang C, Cao X-P, Tan L, Yu J-T. Models for predicting risk of dementia: a systematic review. J Neurol Neurosurg Psychiatry. 2019;90(4):373–9.

Article  PubMed  Google Scholar 

John LH, Kors JA, Fridgeirsson EA, Reps JM, Rijnbeek PR. External validation of existing dementia prediction models on observational health data. BMC Med Res Methodol. 2022;22(1):311.

Article  PubMed  PubMed Central  Google Scholar 

Goerdten J, Čukić I, Danso SO, Carrière I, Muniz-Terrera G. Statistical methods for dementia risk prediction and recommendations for future work: a systematic review. Alzheimer’s Dementia: Translational Res Clin Interventions. 2019;5(1):563–9.

Google Scholar 

Anstey KJ, Zheng L, Peters R, Kootar S, Barbera M, Stephen R et al. Dementia risk scores and their role in the implementation of risk reduction guidelines. Front Neurol. 2022;12.

Kivipelto M, Ngandu T, Laatikainen T, Winblad B, Soininen H, Tuomilehto J. Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. Lancet Neurol. 2006;5(9):735–41.

Article  PubMed  Google Scholar 

Möllers T, Stocker H, Perna L, Rujescu D, Holleczek B, Schöttker B et al. Subjective short-term memory difficulties at ages 50–75 predict dementia risk in a community-based cohort followed over 17 years. Age Ageing. 2022;51(6).

Jessen F, Amariglio RE, Buckley RF, van der Flier WM, Han Y, Molinuevo JL, et al. The characterisation of subjective cognitive decline. Lancet Neurol. 2020;19(3):271–8.

Article  PubMed  PubMed Central  Google Scholar 

Robertson FE, Jacova C. A systematic review of subjective cognitive characteristics predictive of longitudinal outcomes in older adults. Gerontologist. 2022.

Rabin LA, Smart CM, Amariglio RE. Subjective cognitive decline in preclinical Alzheimer’s Disease. Annu Rev Clin Psychol. 2017;13:369–96.

Article  PubMed  Google Scholar 

Clark K, Leung YY, Lee WP, Voight B, Wang LS. Polygenic risk scores in Alzheimer’s Disease Genetics: methodology, applications, inclusion, and Diversity. J Alzheimers Dis. 2022;89(1):1–12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leonenko G, Baker E, Stevenson-Hoare J, Sierksma A, Fiers M, Williams J, et al. Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores. Nat Commun. 2021;12(1):4506.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baker E, Escott-Price V. Polygenic Risk Scores in Alzheimer’s Disease: Current Applications and Future Directions. Front Digit Health. 2020;2.

Stocker H, Perna L, Weigl K, Möllers T, Schöttker B, Thomsen H, et al. Prediction of clinical diagnosis of Alzheimer’s disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years. Mol Psychiatry. 2021;26(10):5812–22.

Article  CAS  PubMed  Google Scholar 

Escott-Price V, Sims R, Bannister C, Harold D, Vronskaya M, Majounie E, et al. Common polygenic variation enhances risk prediction for Alzheimer’s disease. Brain. 2015;138(12):3673–84.

Article  PubMed  PubMed Central  Google Scholar 

Chaudhury S, Patel T, Barber IS, Guetta-Baranes T, Brookes KJ, Chappell S, et al. Polygenic risk score in postmortem diagnosed sporadic early-onset Alzheimer’s disease. Neurobiol Aging. 2018;62:244e1. e1-.e8.

Article  Google Scholar 

Trares K, Bhardwaj M, Perna L, Stocker H, Petrera A, Hauck SM, et al. Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study. Alzheimers Res Ther. 2022;14(1):128.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stocker H, Beyer L, Trares K, Perna L, Rujescu D, Holleczek B, et al. Association of kidney function with development of Alzheimer Disease and other dementias and dementia-related blood biomarkers. JAMA Netw Open. 2023;6(1):e2252387.

Article  PubMed  PubMed Central  Google Scholar 

Löw M, Stegmaier C, Ziegler H, Rothenbacher D, Brenner H. [Epidemiological investigations of the chances of preventing, recognizing early and optimally treating chronic diseases in an elderly population (ESTHER study)]. Dtsch Med Wochenschr. 2004;129(49):2643–7.

Article  PubMed  Google Scholar 

Royston P, Sauerbrei W. Building multivariable regression models with continuous covariates in clinical epidemiology–with an emphasis on fractional polynomials. Methods Inf Med. 2005;44(4):561–71.

Article  CAS  PubMed  Google Scholar 

Anderson CA, Pettersson FH, Clarke GM, Cardon LR, Morris AP, Zondervan KT. Data quality control in genetic case-control association studies. Nat Protoc. 2010;5(9):1564–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Das S, Forer L, Schönherr S, Sidore C, Locke AE, Kwong A, et al. Next-generation genotype imputation service and methods. Nat Genet. 2016;48(10):1284–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR, Teumer A, et al. A reference panel of 64,976 haplotypes for genotype imputation. Nat Genet. 2016;48(10):1279–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stocker H, Perna L, Weigl K, Möllers T, Schöttker B, Thomsen H et al. Prediction of clinical diagnosis of Alzheimer’s disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years. Mol Psychiatry. 2020.

Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, et al. Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat Genet. 2019;51(3):414–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

May S, Hosmer DW. A cautionary note on the use of the Grønnesby and Borgan goodness-of-fit test for the Cox proportional hazards model. Lifetime Data Anal. 2004;10(3):283–91.

Article  PubMed  Google Scholar 

Pencina MJ, D’Agostino RB, Sr., D’Agostino RB Jr., Vasan RS. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med. 2008;27(2):157–72. discussion 207 – 12.

Article  PubMed  Google Scholar 

Pencina MJ, D’Agostino RB, Sr., Demler OV. Novel metrics for evaluating improvement in discrimination: net reclassification and integrated discrimination improvement for normal variables and nested models. Stat Med. 2012;31(2):101–13.

Article  PubMed  Google Scholar 

Scharre DW, Chang S-I, Murden RA, Lamb J, Beversdorf DQ, Kataki M, et al. Self-administered gerocognitive examination (SAGE): a brief cognitive Assessment instrument for mild cognitive impairment (MCI) and early dementia. Alzheimer Disease Assoc Disorders. 2010;24(1):64–71.

Article  Google Scholar 

Scharre DW, Chang SI, Nagaraja HN, Wheeler NC, Kataki M. Self-administered gerocognitive examination: longitudinal cohort testing for the early detection of dementia conversion. Alzheimers Res Ther. 2021;13(1):192.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Silvan Licher MD, Maarten JG, Leening MD,, PD, Pinar Yilmaz MD, Wolters FJ,, MDPD, Heeringa J,, MDPD, Patrick JE, Bindels MD,, PD, et al. Development and validation of a dementia risk prediction model in the General Population: an analysis of three longitudinal studies. Am J Psychiatry. 2019;176(7):543–51.

Verhaaren BFJ, Vernooij MW, Koudstaal PJ, Uitterlinden AG, van Duijn CM, Hofman A, et al. Alzheimer’s Disease genes and cognition in the Nondemented General Population. Biol Psychiatry. 2013;73(5):429–34.

Article  CAS  PubMed  Google Scholar 

Earl Robertson F, Jacova C. A systematic review of subjective cognitive characteristics predictive of longitudinal outcomes in older adults. Gerontologist. 2023;63(4):700–16.

Article  PubMed  Google Scholar